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Nükleer matriks protein 22'nin mesane kanserli hastalarda rekürrensleri belirleyebilme yeterliliği

Adequacy of nucleer matrix protein 22 to determine recurrences in patients with bladder cancer

Journal Name:

  • Abant Tıp Dergisi

Publication Year:

  • 2012
DOI: 
http://dx.doi.org/10.5505/abantmedj.2012.68077

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Aim: To investigate the ability of nuclear matrix protein 22 (NMP22) to determine recurrence in patients un-derwent transurethral resection of bladder tumor (TUR-M) Material and methods: NMP22 measured in urine of 148 patients applied TUR-M. According to cystoscopy and pathology results, the sensitivity, specifity, positive and negative predictive value of NMP22 test was determined in patients suspected bladder cancer recurrancy. Fur-thermore, the effects of urine erythrocyte and leukocyte levels on NMP22 test were investigated. Results: We calculated the sensitivity %36.8, specifity %88, positive predictive value %32 and negative predic-tive value %90. There was statically significant relation between urine leukocyte amount and NMP22 (r=0,237, p<0.04). There was no statically significant relation be-tween urine erythrocyte amount and NMP22 (r=0,04, p=0,958). Conclusion: NMP22 may contribute to determine recur-rences in follow-up of the patients underwent TUR-M .
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Abstract (Original Language): 
uygulanan hastalarda Nükleer Matriks Protein 22 (NMP22)’nin rekürrens belirleyebilme yeteneğinin araştı-rılması. Gereç ve Yöntem: TUR-M tedavisi uygulanmış 148 has-tanın idrarında NMP22 ölçümü yapıldı. Sistoskopi sonuç-larına göre ve mesane kanseri rekürrensi şüphelenilip patolojiye gönderilen vakaların sonuçlarına göre NMP22 testinin duyarlılığı, özgüllüğü, pozitif ve negatif kestirim değeri belirlendi. Ayrıca idrardaki eritrosit ve lökosit düzeylerinin NMP22 testine etkisi araştırıldı. Bulgular: Duyarlılığı %36,8, özgüllüğü %88, negatif kestirim değeri %90, pozitif kestirim değeri %32 olarak hesapladık. İdrarda lökosit miktarı ile NMP22 değerleri arasında istatistikî bakımdan ilişki tespit ettik ( r=0,237, p<0.04 ) . Eritrosit miktarı ile NMP22 değerleri arasında böyle bir ilişki yoktu( r=0,04, p=0,958 ). Sonuç: TUR-M geçirmiş hastaların takibinde NMP22’nin rekürrensleri belirlemeye katkısı olabilecektir.
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  • 1
18-22
  • Turkish

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