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A REVIEW ON EDIBLE VACCINES

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Abstract (2. Language): 
Vaccines and antibodies play a key role in healthcare. However, the cost of production and maintaining a chain for vaccine distribution has so far hampered realizing their full potential. Expression of antigens as vaccines and of antibodies against antigens of pathogens in transgenic plants is a convenient and inexpensive source for these immunotherapeutic molecules. Edible plant vaccine against diarrhea, expressed in potato, HIV/AID'S, expressed in tomato, is already in preclinical human trials. Attempts are being made to express many proteins of immunotherapeutic use at high levels in plants and to use them as bio-reactors of the modern era. Research underway is dedicated to solving these limitations by finding ways to produce oral (Edible) vaccines in transgenic plants.

REFERENCES

References: 

1.
A
review of the progression of transgenic plants used to produce plant bodies for human usage, journal of young investigators. 2001; 4.
2. Hein
MB
, Yeo TC, Wang F and Sturtevant A: Ann. NY Acad. Sci., 1996; 792: 51-56.
3.
M
a SW, Zhao, DL, Yin ZQ, Mukherjee R, Singh B, Quin HY, Stiller C R and Jevnikar AM: Nature Med. 1997; 3: 793¬796.
4.
Thanaval
a Y, Yang YF, Lyons P, Mason HS and Arntzen C: Proc. Natl. Acad. Sci. USA, 1995; 92: 3358-3361.
5. Arakawa T, Chong DKX and Langridge WHR: Transgenic plants for the production of edible vaccine and antibodies for immunotherapy. Nature Biotechnology 1998; 16: 292-297.
6. Arakawa T, Chong DKX, and Langridge WHR: Expression of Choleratoxin B subunit oligomers in transgenic potato plants, Transgenic Res. 1997; 6: 403-413.
7. Artsaenko O, Peisker M, Zurniedan U, Fielder U, Weiler EW, Muntz K, Conrad U: Expression of a single chain FV antibody against abscisic acid creates a wilty phenotypes in transgenic tobacco. Plant J. 1995; 8: 745-750.
8.
Dr
. U. Satyanarayanan: Biotechnology, Books & allied (P) Ltd, Kolkatta: 572-573.

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