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DİFFÜZ BÜYÜK B-HÜCRELİ LENFOMA VE LUPUS VULGARİS: İKİ HASTALIĞIN HİKAYESİ

DIFFUSE LARGE B-CELL LYMPHOMA AND LUPUS VULGARIS: A TALE OF TWO DISEASES

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Multi-drug resistant tuberculosis is problematic in immunocompromised individuals. In such patients, CD4 lymphocytopenia appears to correlate with the severity of the disease and with low interferon gamma production in response to infection with Mycobacterium tuberculosis. Treatment with interferon gamma may be a useful adjunct therapy in those patients. In this report, we describe a patient with idiopathic CD4 lymphocytopenia who presented with diffuse large B cell lymphoma after interferon gamma therapy for drug resistant tuberculosis. Gamma interferon treatment may be of benefit to patients with impaired cellular immune response. Before that therapy is initiated the clinicians should consider the patient's CD4 cell count considered carefully.
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Abstract (Original Language): 
BağıĢıklık sistemi zayıflamıĢ hastalarda çok ilaca dirençli tüberküloz bir problemdir. Bu hastalarda CD4 lenfositopenisi hastalığın Ģiddeti ile iliĢkilidir ve mycobacterium tuberculosis enfeksiyonuna yanıt olarak düĢük gamma interferon üretiminden sorumludur. Bu hastalarda gamma interferon tedavisi faydalı bir yardımcı tedavi olabilir. Bu yazıda idiopatik CD4 lenfositopenisi olan bir hastada çok ilaca dirençli tüberküloz nedeniyle gamma interferon tedavisi sonrası diffüz büyük B hücreli lenfoma geliĢmesi tanımlanmaktadır. BağıĢıklık sistemi baskılanmıĢ olan hastalarda gamma interferon tedavisi faydalı olabilir fakat bu tedaviye baĢlamadan önce klinisyenler hastanın CD4 hücre sayısına dikkat etmelidirler ve bu bilgi tedavi seçeneklerine karar verilmeden önce dikkatli bir Ģekilde düĢünülmelidir.
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  • 3
49-51
  • English

REFERENCES

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