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NONALKOLİK KARACİĞER YAĞLANMASI VE STEATOHEPATİT

NONALCOHOLIC FATTY LIVER DISEASE AND STEATOHEPATITIS

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Abstract (2. Language): 
Nonalcoholic fatty liver disease (NAFLD) is now recognized as one of the most common liver diseases in the world. It has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis), and hepatocellular carcinoma. It is associated with insulin resistance and frequently occurs with features of the metabolic syndrome. Disease presentation ranges from asymptomatic elevated liver enzyme levels to cirrhosis with complications of liver failure. In this article we discuss the etiology, pathogenesis and diagnosis of nonalcoholic fatty liver disease as well as approaches to its management.
Abstract (Original Language): 
Nonalkolik karaciğer yağlanması (NAFLD), artık dünyada en yaygın karaciğer hastalığı olarak kabul edilmektedir. Bu, basit steatozdan steatohepatite, son dönem karaciğer hastalığına (siroz) ve hepatoselüler karsinoma kadar gidebilen farklı derecedeki durumlar için kullanılan genel bir isimdir. Bu durum sıklıkla metabolik sendromun özelliklerini gösterir ve insülin rezistansı ile iliĢkilidir. Hastalık asemptomatik karaciğer enzim yüksekliğinden siroza ve karaciğer yetersizliğinin komplikasyonlarına kadar değiĢik Ģekillerde görünmektedir. Bu derlemede NAFLD etiyolojisi, patogenezi, tanısı ve tedavi yaklaĢımları tartıĢılmıĢtır.
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