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Proantosiyanidin nitrojen mustarda bağlı akciğer hasarını azaltır

Proanthocyanidine alleviates lung damage induced by nitrogen mustard

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Destructive properties of nitrogen mustard especially on respiratory system make it an effective chemical weapon with lack of an antidote. The aim of this study was to investigate the role of oxidative stress in mustard toxicity and the protective effect of proanthocyanidine. Rats were separated into three groups each containing fifteen rats. The three groups were control group which were exposed to none, nitrogen mustard group administered nitrogen mustard, and the last group administered nitrogen mustard and fed with proanthocyanidine containing diet (nitrogen mustard plus proanthocyanidine group). We demonstrated the harmful effects of nitrogen mustard over oxidative stress, and the therapeutic effects of proanthocyanidine by both histopathologically and biochemically using the oxidative stress parameters such as malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase. Significant histopathologic lung lesions such as alveolar edema and alveolar congestion were observed in the nitrogen mustard group. Those lesions were less severe in the nitrogen mustard plus proanthocyanidine group. Proanthocyanidine treatment decreased malondialdehyde levels, which were initially elevated by nitrogen mustard administration, while superoxide dismutase, catalase and glutathione peroxidase activities remained similar to those of the nitrogen mustard only group. Our results revealed that oxidative stress has played a major role in mustard toxicity, and proanthocyanidine has had a substantial role in decreasing the toxic outcomes.
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Abstract (Original Language): 
Antidotu bulunmayan nitrojen mustard gazının özellikle solunum sistemi üzerinde görülen yıkıcı etkisi onu etkili bir kimyasal silah yapmaktadır. Bu çalışmanın amacı mustard toksisitesinde oksidatif stresin rolünün ve proantosiyanidinin koruyucu etkisinin araştırılmasıydı. Ratlar her biri on beş hayvan içeren üç gruba ayrıldı. Bu üç grup hiç bir şeye maruz bırakılmamış kontrol grubu, nitrojen mustard uygulanmış grup ve nitrojen mustard uygulanmış ve proantosiyanidin içeren diyetle beslenmiş gruplardı. Nitrojen mustardın oksidatif stres üzerinden zararlı etkileri ve proantosiyanidinin terapötik etkileri hem histopatolojik hem de biyokimyasal olarak malondialdehid, süperoksid dismutaz, katalaz ve glutatyon peroksidaz gibi oksidatif stres parametreleri kullanılarak gösterildi. Nitrojen mustard grubunda alveolar ödem ve alveolar konjesyon gibi anlamlı histopatolojik akciğer lezyonları gözlendi. Bu lezyonlar nitrojen mustard uygulanmış ve proantosiyanidin içeren diyetle beslenmiş grupta daha az şiddette gözlendi. Proantosiyanidin tedavisi nitrojen mustard uygulamasıyla başlangıçta yükselmiş olan malondialdehid seviyelerini düşürürken, süperoksid dismutaz, katalaz ve glutatyon peroksidaz aktiviteleri nitrojen mustard grubuyla aynı seviyede kaldı. Sonuçlarımız mustard toksisitesinde oksidatif stresin önemli rol oynadığını ve proantosiyanidinin toksik sonuçların azaltılmasında önemli bir etkiye sahip olduğunu göstermiştir.
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  • 4
267-272
  • English

REFERENCES

References: 

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