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İmplantasyon ve moleküler etkileşimler

Implantation and Molecular Interactions

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Implantation is a successful fusion between embryonic and maternal tissues which are genetically different. Trophoblast cells of the developing embryo are employee not only for transporting oxygen and nutrients from the mother to the fetus but also for their array of other functions throughout the pregnancy beginning from the attachment of the blastocyst to the endometrium during the process of implantation. The functions which subsequently maintain the pregnancy are; regular invasion to the uterine tissue, proliferation, differentiation and immuno-endocrine functions. İn this article, we mention about the signalling events between endometri-um and blastocyst before the beginning of implantation and the adhesion molecules which have a role in the attachment and invasion of blastocyst to the endometrium. Whereas some of the events in implantation are similar with inflamatuary, some of them are similar with events in tumour invasion. However, contrary to these events, implantation contains a serial of completely controlled events which are regulated by various fac¬tors. Apoptosis was found on uterine epithelial cells in implantation period. İt is determined that apoptosis which take place in implantation window space is required both in invasion of embryo into the endometrium and in maternal blood flow to embryo. When we have a look at the factors which regulate both implantation and apoptosis, due to the fact that these factors are common in both events, it is seen that they have an influ¬ence in both events and they ensure a good embryo development in a controlled way.
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Abstract (Original Language): 
İmplantasyon genetik olarak farklı olan embriyonik ve maternal dokular arasında gelişen başarılı bir kaynaşmadır. Gelişen embriyodaki trofoblast hücreleri, anneden fetüse oksijen ve besinlerin taşınması yanında, implantasyon süreci esnasında blastokistin endometriyuma tutunmasından başlayarak gebeliğin başından sonuna kadar diğer işlevlerin yerine getirilmesinde de görevli hücrelerdir. Gebeliğin devamını sağlayan bu işlevler; uterus dokusuna düzenli invazyon, çoğalma, farklılaşma ve immuno-endokrin fonksiyonlardır. Bu makalede, implantasyon başlamadan önce endometriyum ile blastokist arasındaki sinyalleşme olayları ve blastokistin endometriyuma tutunma ve invazyonunda rol oynayan adezyon moleküllerinden bahsedeceğiz. İmplantasyondaki bazı olaylar inflamatuar, bazıları da tümör invazyonundaki olaylara benzerlik göstermek¬tedir. Fakat bunların tersine implantasyon tamamen kontrollü ve çeşitli faktörlerle düzenlenen bir dizi olay¬ları içermektedir. İmplantasyon döneminde uterus endometriyum hücrelerinde apoptozis tespit edilmiştir. İmplantasyon penceresi döneminde gerçekleşen apoptozisin hem embriyonun endometriyum içine invazy-onunda, hem de embriyoya maternal kan akımının sağlanmasında gerekli olduğu tespit edilmiştir. Hem implantasyonu, hem de apoptozisi düzenleyen faktörlere baktığımızda, bu faktörlerin her iki olayda da ortak olması nedeniyle, her iki olayda etkili oldukları ve iyi bir embriyo gelişimini kontrollü bir şekilde sağladıkları görülmektedir.
FULL TEXT (PDF): 
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  • 4
25-33
  • Turkish

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