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Nonsteroidal anti-inflamatuvar ilaçları n gebelikteki toksisiteleri ile ilgili literatürlerin gözden geçirilmesi

The looking over the literatures interested in the pregnancy toxicity of nonsteroidal anti enflamatuar drugs

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Nonsteroidal anti-inflammatory drugs are generally used for the treatment of pain, fever and inflammation in rheumatic diseases. The threapy of active rheumatic diseaese in pregnancy was important for the mother's health and development for the fetus. However, knowledge on the use of antirheumatic drugs during preg¬nancy is limited. Studies on the effect of nonsteroidal anti-inflammatory drugs in the treatment of rheumatoid artiritis have concentreated on aspirin and indomethacin. İnformation about the use of ibuprofen, sulindac, ketoprofen and diclofenac during pregnancy is limited. There is no evidence for teratogenicity of any NSAİD in humans. As NSAİD given during pregnancy have the potential to cause adverse maternal and fetal effects. Application of NSAİD as a part of arthritic or tocolitic treatment during the last trimester of gestation should be performed very carefully, since Diclofenac Sodium given during pregnancy, maternal effects include the prolongation of pregnancy and labor, reported adverse fetal effect of NSAİD include constricted ductus arte-riosus, hidrops fetalis, oligohydroamnios, ileal perforation and cyctic brain lesions, result in paranchymal degeneration especially in liver in postnatal period.
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Abstract (Original Language): 
Nonsteroidal anti-inflamatuva r ilaç (NSAÜ)'lar genellikle romatizmal hastalıklarda, ağrı, ateş ve enflamasy-onun tedavisi için kullanılır. Gebelikteki aktif romatizmal hastalığın tedavi edilmesi, anne sağlığı ve fetüsün gelişimi için önemlidir. Hamilelikte antiromatizmal ilaçların kullanımı üzerine bilgiler sınırlıdır. NSAÜ'ların romatoid artirit tedavisindeki etkisi aspirin ve indometazinde incelenmiştir. Bunun yanında, ibuprofen, sulin-dak, ketoprofen ve diklofenak'ın gebelikte kullanımı hakkında bilgiler çok sınırlıdır. Herhangi bir NSAİTın gebelerde kullanımını takiben teratojeniteye yol açtığına dair bir kanıt yoktur. Fakat, NSAİTın gebelik süresince kullanımının annede ve fetusde yan etkilere yol açtığı bildirilmiştir. Hamileliğin son trimestirinde artrit veya tokolitik tedavi amacıyla uygulamada kullanılan NSAİİ'da çok dikkatli olunmalıdır. Hamilelikte verilen diklofenak sodyum'un gebelik ve doğum süresini uzattığı gözlenmiştir. Postnatal dönemde duktus arteriosusta (DA) kasılma, hidrops fetalis, oligohidroamnios, ileal perforasyon, beyinde kistik lezyonlar, özel¬likle karaciğerde parankimal dejenerasyona yol açtığı görülmüştür.
FULL TEXT (PDF): 
PDF icon arastirmax-nonsteroidal-anti-inflamatuvar-ilaclari-n-gebelikteki-toksisiteleri-ile-ilgili-literaturlerin-gozden-gecirilmesi.pdf
  • 3
50-52
  • Turkish

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