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Alfentanil İnfüzyonu ile Oluşturulan Genel Anestezinin Hemodinami ve Uyanma Üzerine Etkileri

The Effects of General Anaesthesia Induced by Alfentanyl Infusion on Hemodynamia and Awakening

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Abstract (2. Language): 
The aim of this study is, to investigate the effect of alfentanil anaesthesia, which is applied on patients with cardiac problems (ASA II-III) and non- cardiac problems (ASA-I) on hemodynamic values, weaning and postoperative nausea vomiting. In group I (n=20); alfentanil was infused 10 jug/kg/min rate at a 150 jug kg-1 total dose and in group II it was infused 6 pig/kg/min rate at a 90 jug/kg total dose. At the end of the infusion 0.03 mg/kg flunitrazepam and 0.03 mg/kg atracurium were administered and endotracheal intubation was maintained when the muscle relaxation is enough. Anesthesia maintenance was performed with 2.5 fig/kg/dk/min alfentanyl in group I and 1.5 /ug/kg/min in group II in addition to 4 L/min 02 ± 4 L/min N20. Alfentanyl infusion and N20 inhalation were stopped 20 min before the final of operation. Systolic and diastolic arterial pressure and heart rate were recorded before anaesthesia induction and taken as control values. These were recorded at 1., 5., 10., 15 minutes of induction, before and after surgical incision, during operation with 10 minutes intervals and 5 minutes after the alfentanyl infusion has been stopped. The hemodynamic parameters were worsened in both two groups at inductions and maintenance of anaesthesia. In group I there was no treatment need but in group II hypotension and bradicardia was treated. Lack of anaesthesia was seen in any of the groups. As a conclusion; we think that high dose alfentanyl is a good alternative to inhalation anaesthesia by preventing negative responses to laryngoscopy, intubation, and surgical stimuluses and by performing a stabile hemodynamia and anaesthesia when it is combined with a hypnotic agent in high risky cases, which are planned for non-cardiac surgery.
Abstract (Original Language): 
Bu çalışmanın amacı, kardiyak problemleri olmayan (ASA I) ve olan (ASA II-III) iki grupta yüksek doz alfentanil ile oluşturulan anestezinin hemodinami, uyanma kriterleri ve postoperatif bulantı kusma üzerine etkilerini araştırmaktır. Grup 1 (n: 20) olgularda 150 ng/kg dozda alfentanil 10 /ug/kg/dk hızla, grup II (n: 20) olgularda 90 jug/kg dozda alfentanil 6 jug/kg/dk hızla infüze edildi İnfüzyon bitiminde 0.03 mg/kg flunitrazepam ve 0.3 mg/kg atrakuryum iv verildi. Kas gevşemesinin yeterli olduğu an endotrakeal entübasyonla anestezi indüksiyonu tamamlandı. Anestezi idamesi grup I'de 2.5 jug/kg/dk, grup II'de 1.5 /ug/kg/dk dozda alfentanil infüzyonu ve 4 L/dk ö2 + 4 L/dk N2Ö ile sağlandı. Alfentanil infüzyonu ve N2Ö inhalasyonu operasyon bitiminden 15-20 dk önce sonlandırıldı. Anestezi indüksiyonu öncesi SAB, DAB, KAH değerleri kaydedilerek kontrol değeri olarak kullanıldı. SAB, DAB, KAH indüksiyonun 1., 5., 10., 15. dakikalarında, cerrahi insizy ondan önce ve sonra, operasyon süresince 10 dakikalık aralarla, alfentanil infüzyonunun sonlandırılmasından sonra 5 dakika aralarla kaydedildi. Hemodinamik parametreler iki grupta da indüksiyön ve anestezi idamesi süresince düştü. Grup I'deki düşüşler tedavi gerektirmezken; grup II'de bir olguda gelişen hipotansiyon ve dört olguda gelişen bradikardi tedavi gerektirdi. Hiçbir olguda anestezi süresince anestezi yetersizlik kriteri gözlenmedi. Sonuç olarak nonkardiyak cerrahi planlanan riskli olgularda yüksek doz alfentanil infüzyonunun; hipnotik bir ajanla kombine edildiğinde laringoskopi, entübasyon ve cerrahi uyaranlara karşı olumsuz yanıtları önleyerek stabil hemodinami ve güvenli bir anestezi ile inhalasyon anestezisine iyi bir alternatif olacağını düşünmekteyiz.
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