You are here

C-Reaktif Protein Ventriküler Trombus Varlığı İçin Bağımsız Bir Risk Faktörü Değildir

C-Reactive Protein is not an Independent Risk Factor for Ventricular Thrombus

Journal Name:

Publication Year:

Abstract (2. Language): 
C-reactive protein (CRP) is a standard and widely used acute phase reactant. It is a prototypic marker of inflammation and an adverse event indicator. Elevated CRP levels have been found to be correlated with higher risk for potential adverse cardiac events in patients with acute myocardial infarction, stable and unstable coronary artery disease. However the relationship between presence of left ventricular thrombus (LVT) and levels of CRP have not been investigated in the patients undergoing left ventricular restorative operations. In order to investigate the correlation and seek out the ability of the predictive value of CRP levels in patients with left ventricular aneurysm (LVA), we studied operational and biochemical findings of our patients with LVA, who underwent coronary revascularization operations. We found that CRP levels do not predict presence of LVT.
Abstract (Original Language): 
C-reaktif protein (CRP) yaygın kullanılan ve standart bir akut faz reaktanıdır. Yüksek CRP değerlerinin akut miyokard enfarktüsü, stabil ve anstabil koroner arter hastalığında ileride oluşabilecek olumsuz (advers) kardiyak olaylarda ilişkili olduğu gösterilmiştir. Ancak sol ventrikül onarımları yapılan hastalarda sol ventrikül trombüsü (SVT) ve CRP değerleri arasında bir ilişkinin varlığı araştırılmamıştır. Biz böyle bir korelasyonun var olup olmadığını ve sol ventrikül anevrizması (SVA) olan hastalardan alınan CRP değerlerinin trombüs varlığı konusundaki prediktif değerlerini araştırmak için SVA olup koroner revaskülarizasyon ameliyatına giden hastalarımızın cerrahi ve biyokimyasal verilerini gözden geçirdik. CRP değerlerinin SVT varlığı üzerinde önceden belirleyici (prediktif) değerinin olmadığını tespit ettik.
66-70

REFERENCES

References: 

1. Gaudino M, Nasso G, Andreotti F, et al. Preoperative Creactive
protein level and outcome following coronary
surgery. Eur J Cardio-thorac Surg 2002; 22: 521-6. DOI:
10.1016/S1010-7940(02)00436-0
2. Devaraj S, Singh U, Jialal I. The evolving rule of Creactive
protein in atherothrombosis. Clin Chem 2009; 55:
229-38. DOI: 10.1373/clinchem.2008.108886
3. Yasojima K, Schwab C, McGeer EG, McGeer PL.
Generation of C-reactive protein and complement
components in atherosclerotic plaques. Am J Pathol 2001;
158: 1039-51. DOI: 10.1016/S0002-9440(10)64051-5
4. Paffen E, Vos HL, Bertina RM. C-reactive protein does
not directly induce tissue factor in human monocytes.
Arterioscler hromb Vasc Biol 2004; 24: 975-81. DOI:
10.1161/01.ATV.0000126681.16619.69
5. Çelik S, Baykan M, Erdöl C, et al. C-reactive protein as a
risk factor for left ventricular thrombus in patients with
acute myocardial infarction. Clin Cardiol 2001; 24: 615-9.
DOI: 10.1002/clc.4960240909
6. Anzai T, Yoshikawa T, Kaneko H, et al. Association
between serum C-reactive protein elevation and left
ventricular thrombus formation after first myocardial
infarction. Chest 2004; 125: 384-9. DOI:
10.1378/chest.125.2.384
7. Sabatine MC, Morrow DA, Jablonski KA, et al. PEACE
investigators. Prognostic significance of the centers for
disease control/American Heart Association high
sensitivity C-reactive protein cut points for cardiovascular
and other outcomes in patients with stable coronary artery
disease. Circulation 2007; 115: 1528-36. DOI:
10.1161/CIRCULATIONAHA.106.649939
8. Versaci F, Gaspardone A, Tomai F, et al. Predictive value
of C-reactive protein in patients with unstable angina
pectoris undergoing coronary artery stent implantation.
Am J Cardiol 2000; 85: 92-5. DOI: 10.1016/S0002-
9149(99)00612-8
9. Biancari F, Lahtinen J, Lepojärvi S, et al. Preoperative Creactive
protein and outcome after coronary artery bypass
surgery. Ann Thorac Surg 2003;76: 2007-12. DOI:
10.1016/S0003-4975(03)01067-1
10. Bisoendial RJ, Kastelein JJ, Levels JH, et al. Activation of
inflammation and coagulation after infusion of C-reactive
protein in humans. Circ Res 2005; 96: 714-6. DOI:
10.1161/01.RES.0000163015.67711.AB
11. Palmerini T, Marzocchi A, Reggiani LB, et al.
Preoperative C-reactive protein levels predict 9-month
mortality after coronary artery bypass surgery for the
treatment of left main coronary artery stenosis. Eur J
Cardiothorac Surg 2007; 31: 685-90. DOI:
10.1016/j.ejcts.2006.12.029
12. Seo Y, Maeda H, Ishizu T, et al. Peak C-reactive protein
concentration correlates with left ventricular thrombus
formation diagnosed by contrast echocardiographic left
ventricular opacification in patients with a first anterior
acute myocardial infarction. Circ J 2006; 70: 1290-6. DOI:
10.1253/circj.70.1290
13. Toss H, Lindahl B, Siegbahn A, Wallentin L, for the
FRISC study group. Prognosticinfluence of increased
fibrinogen and C-reactive protein levels in unstable
coronary artery disease. Circulation 1997; 96: 4204-10.
14. Danenberg HD, Szalai AJ, Swaminathan RV, et al.
Increased thrombosis after arterial injury in human CC-
Reactive Protein is not an Independent Risk Factor for Ventricular Thrombus
70
reactive protein-transgenic mice. Circulation 2003; 108:
512-15. DOI: 10.1161/01.CIR.0000085568.13915.1E
15. Singh U, Devaraj S, Jialal I. C-reactive protein decreases
tissue plasminogen activator activity in human aortic
endothelial cells: Evidence that C-reactive protein is a
procoagulant. Arterioscler Thromb Vasc Biol 2005; 25:
2216-21. DOI: 10.1161/01.ATV.0000183718.62409.ea
16. Pandolfi A. C-reactive protein: A potential new molecular
link between inflammation, thrombosis and vascular cell
proliferation? Cardiovasc Res 2005; 68: 3-4. DOI:
10.1016/j.cardiores.2005.07.019
17. Cirillo P, Golino P, Calabró P, et al. C-reactive protein
induces tissue factor expression and promotes smooth
muscle and entrhelial cell proliferation. Cardiovasc Res
2005; 68: 47-55. DOI: 10.1016/j.cardiores.2005.05.010
18. Cermak J, Key NS, Bach RR, et al. C-reactive protein
induces human peripheral blood monocytes to synthesize
tissue factor. Blood 1993; 82: 513-20.
19. Balciunas M, Bagdonaite L, Samalavicius R, Griskevicius
L, Vuylsteke A. Pre-operative high sensitive C-reactive
protein predicts cardiovascular events after coronary
artery bypass grafting surgery: A prospective
observational study. Ann Card Anaesth 2009; 12: 127-32.
DOI: 10.4103/0971-9784.53442
20. Clearfield MB. C-reactive protein: A new risk assessment
tool for cardiovascular disease. JAOA 2005; 105: 409-16.

Thank you for copying data from http://www.arastirmax.com