You are here

Home » Content

Intrauterin Inseminasyon ile Elde Edilen Gebeliklerde ikinci Trimester Down's Sendromu Üçlü Tarama Testi Belirteçlerinin Değerlendirilmesi

The Evaluation of Second Trimester Down's Syndrome Triple Serum Screening Test in Intrauterine Insemination Pregnancies

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Objective: To evaluate second trimester maternal serum total human chorionic gonadotrophin (HCG) , alpha-feto protein (AFP) and unconjugated estriol (uE3) concentration in singleton pregnancies conceived from intrauterine insemination (IUI) Material and Methods: Second trimester (16-20 weeks) maternal serum levels of alpha- feto protein (AFP) , unconjugated estriol (uE3) and total human chorionic gonadotrophin (hCG) were measured and expressed as multiples of median (MoM) values in 28 patients conceiving singleton pregnancies by intrauterine insemination (IUI). The results were compared with those of 82 naturally occuring singleton pregnancies who had serum screening at 16-20 weeks at the same laboratory over the same period of time. Results: There were no significant differences between the study and control groups in maternal body weight, age, gestational week and habitus of cigarette smoking. The median levels of the triple markers were 1.03±0.66 MoM for hCG, 1.09±0.32 MoM for AFP and 1.06±0.01 MoM for uE3 in the IUI pregnancies. The values of hCG,AFP and uE3 were not significantly different from that in controls. No women were found to be screen positive. In neither group were chromosomal abnormalities detected and no fetal or neonatal deaths were recorded. Conclusions: Based on our findings, IUI did not significantly affect the results of maternal serum Down's syndrome screening.
Bookmark/Search this post with
Abstract (Original Language): 
Amaç: Intrauterin inseminasyon(IUI) ile elde edilen tekil gebeliklerde ikinci trimester Down's sendromu üçlü tarama testi belirteçlerinin değerlendirilmesi. Gereç ve Yöntem: IUI ile tekil gebelik elde edilen 28 olguda 16-20.gebelik haftaları arasında serum alfa fetoprotein (AFP), Unkonjuge estriol (uE3 ) ve total human koryonik gonadotropin (hCG ) konsantrasyonları ölçülerek multipl of median (MoM) değerleri hesaplandı. Değerler aynı zaman diliminde spontan gebe kalarak hastanemiz laboratuvarında üçlü tarama testi yaptıran 82 tekil gebenin sonuçları ile karşılaştırıldı. Bulgular: Çalışma ve kontrol grupları arasında anne yaşı ve kilosu , gebelik haftası, sigara alışkanlığı açısından fark yoktu. IUI gebeliklerinde hCG, AFP ve uE3 için MoM değerleri sırasıyla 1.03±0.66 , 1.09±0.32, 1.06±0.01 olarak saptandı. AFP , uE3, total hCG MoM değerleri kontrol grubu ile benzerdi. Hiçbir olguda tarama pozitifliği saptanmadı. Kromozomal anomalili bebek doğumu, fetal ve neonatal ölüm tespit edilmedi. Sonuç: IUI ile elde edilen tekil gebeliklerde AFP , uE3 MoM ,total hCG MoM seviyeleri spontan gebeliklerden farklı bulunmamıştır.
FULL TEXT (PDF): 
PDF icon arastirmax-intrauterin-inseminasyon-ile-elde-edilen-gebeliklerde-ikinci-trimester-downs-sendromu-uclu-tarama-testi-belirteclerinin-degerlendirilmesi.pdf
  • 2
69-71
  • Turkish

REFERENCES

References: 

1. Haddow JE, Palomaki G.E, Knight G.J. Prenatal screening for Down syndrome with use of maternal serum markers . N.Engl.Med,1999; 327:588
2. Phillips O P, Elias S, Shulman L.P . Maternal serum screening for fetal Down's syndrome in women less than 35 years of age using a feto protein, hCG and unconjugated estriol :a prospective 2 year study. Obstet Gynecol 1992; 80:353
3. Wald NJ , Kennard A, Densen J.W. Antenatal maternal serum screening for Down's syndrome:results of a demonstration. Project. Br.Med.J 305:391
4. 4-Palomaki GE, Panizza DS, Canick JA. Screening for Down syndrome using AFP ,E3 and hCG. Effect of maternal weight. Am J.Hum Genet 1990 ; 47:282
5. Palomaki GE, Knight GJ, Haddow JE. Cigarette smoking and levels of maternal serum a feto protein, unconjugated estriol and hCG : impact on Down syndrome screening .Obstet.Gynecol 1993 ;81:675
6 Alpert A, Greenberg F, Conant C. Serum hCG , AFP and unconjugated estriol levels in twin pregnancies in midtrimester. Am.Hum .Genet 1990; 47: 267
7 Wald NJ, Cuckle HS, Densem JW, Stone R . Maternal serum unconjugated estriol , human chorionic gonadotropin and AFP levels in pregnancies with insülin dependent diabetes: Implications for Down syndrome screening. Br.J.Obstet .Gynecol 1992 ;99:51
8 Simpson JL, Elias S, Morgan CD. Second trimester maternal serum human chorionic gonadotropin and unconjugated estriol levels in blacks and whites. Lancet 1990; 1459
9 Heinonen S, Hippelainen M, Ryynanen M. Effect of invitro fertilization on human chorionic gonadotropin serum concentrations and Down's syndrome screening.
Fertil.Steril 1996 ;66:398
10 Ribbert LSM, Kornman LH, De Wolf BTHM. Maternal serum screening for fetal
Down's syndrome in IVF pregnancies. Prenat Diagn 1996 ;16:35
11 Frishman GN, Canick JA, Hogan JW. Serum triple marker screening in invitro fertilization and naturally conceived pregnancies. Obstet Gynecol 1997 ;90:98
12 Wald NJ, White N, Morris JK, Huttly WJ, Canick JA. Serum markers for Down's
syndrome in women who have had invitro fertilization: implications for antenatal
screening. Br.J.Obstet.Gynecol 1999; 106:1304
13 Barkai G, Goldman B, Ries L. Down's syndrome screening marker levels following assisted reproduction . Prenat.Diagn 1996 ;16:1111
14 Hsu TY,Ou CY,Hsu JJ,Kung FT,Chang SY,Soong YK.Maternal Serum screening for Down Syndrome in pregnancies conceived by intrauterine insamination Prenat
Diagn 1999; 19:1012
15 Raty R,Virtanen A ,Koskinen P,Anttila L,Laitinen P,Tiitinen A,Ekblad U .Maternal serum P hCG levels in screening for Down syndrome are higher in singleton pregnancies achieved with ovulation induction and intrauterine insemination than in spontaneous singleton pregnancies Fertil Steril 2001 ;76:1075-1077
16 Perheentupa A, Ruokonen A, Tuomivaara L, Rynanen M, Martikainen H. Maternal serum P HCG and a feto protein concentrations in singleton pregnancies following assisted reproduction. Hum.Reprod 2002 ;17:794
17 Raty R, Virtanen A , Koskinen P, Anttila L, Forsström J, Laitinen P, Tiitinen A, Mörsky P et all.Serum free P hCG and alpha fetoprotein levels in IVF,ICSI and frozen embryo transfer pregnancies in maternal midtrimester serum screening for Down's syndrome.Human reproduction 2002; 17:481-484
18 Maymon R, Shulman A. Comparison of triple serum screening and pregnancy outcome in oocyte donation versus IVF pregnancies.Human Reproduction 2001
;16:691-695
19 Rotmensch S, Celentano C, Shalev J. Midtrimester maternal serum screening after multifetal pregnancy reduction in pregnancies conceived by in vitro fertilization
.J.Assist.Reprod .Genet 1999; 16:8

Thank you for copying data from http://www.arastirmax.com