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Yaşlılık Döneminde Nefrolojik Sorunlar

Nephrologic Problems in Old Age Period

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DOI: 
DOI 10.5262/tndt.2012.1003.03

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Abstract (2. Language): 
The elderly are a fast growing population in the world, and they have a high prevalence of chronic kidney disease. The function of the kidney changes markedly with age. The glomerular fi ltration rate falls progressively, independent of overt pathology. Declining renal function with age has important implications, not only for individual homeostasis but also for the use of drug therapy and for the receipt and donation of organs for transplantation. Aging is associated with structural and functional changes in the kidney. The adaptive capacity of kidney to stress and disease in the elderly is restricted. The clinician should be aware of these alterations in order to anticipate and better treat the clinical conditions that occur in great frequency in elderly. Age-related changes has been reviewed in this manuscript
Abstract (Original Language): 
Yaşlılık dünyada hızla büyüyen bir popülasyondur ve bu grupta kronik böbrek hastalığı prevalansları yüksektir. Böbreğin fonksiyonu da yaşla birlikte belirgin biçimde değişir. Belirgin patolojilerden bağımsız olarak glomerüler fi ltrasyon hızı progresif olarak düşer. Yaşla birlikte böbrek işlevinin azalmasının sadece bireyin homeostazı için değil, ilaç tedavisi kullanımının veya transplantasyon için organ alınması ve bağışı için de önemli anlamları vardır. Yaşlanma böbreklerde hem yapısal hem de fonksiyonel değişikliklere neden olur. Hastalık ya da stres anında, yaşlılarda değişen koşullara böbreğin adaptasyonu azalmaktadır. Klinisyenin yaşlanma ile ortaya çıkan bu değişikliklerden haberdar olması yaşlılarda daha sık rastlanan klinik sorunların engellenmesini ve daha iyi tedavi edilmesini sağlayacaktır.
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REFERENCES

References: 

1. Hansberry MR, Whittier WL, Krause MW: The elderly patient with
chronic kidney disease. Adv Chronic Kidney Dis 2005; 12 (1):
71-77
2. Anderson S, Brenner BM: Progressive renal disease: A disorder of
adaptation. Q J Med 1989; 70 (263): 185-189
3. Baylis C, Corman B: The aging kidney: Insights from experimental
studies. J Am Soc Nephrol 1998; 9 (4): 699-709
4. Ma LJ, Fogo AB: Model of robust induction of glomerulosclerosis
in mice: Importance of genetic background. Kidney Int 2003; 64:
350-355
5. Baylis C, Wilson CB: Sex and the single kidney. Am J Kidney Dis
1989; 13 (4): 290-298
6. Tanaka A, Kyokuwa M, Mori T, Kawashima S: Acceleration of
renal dysfunction with ageing by the use of androgen in Wistar/Tw
rats. In Vivo 1995; 9 (5): 495-502
7. Maric C, Sandberg K, Hinojosa-Laborde C: Glomerulosclerosis and
tubulo-interstitial fibrosis are attenuated with 17 beta-estradiol in
the aging Dahl salt sensitive rat. J Am Soc Nephrol 2004; 15 (6):
1546-1556
8. Takeshita S, Hosokawa M, Irino M, Higuchi K, Shimizu K,
Yasuhira K, Takeda T: Spontaneous age-associated amyloidosis in
the senescence-accelerated mouse (SAM). Mech Ageing Dev 1982;
20 (1): 13-23
9. Yumura W, Imasawa T, Suganuma S, Ishigami A, Handa S, Kubo S,
Joh K, Maruyama N: Accelerated tubular cell senescence in SMP30
knockout mice. Histol Histopathol 2006; 21 (11): 1151-1156
10. Negri AL: The klotho gene: A gene predominantly expressed in the
kidney is a fundamental regulator of aging and calcium/phosphorus
metabolism. J Nephrol 2005; 18 (6): 654-658
11. Marcantoni C, Li-Jun M, Federspiel C, Fogo A: Hypertensive
nephrosclerosis in African Americans versus Caucasians. Kidney
Int 2002; 62 (1): 172-180
12. Martin JE, Sheaff MT: Renal ageing. J Pathol 2007; 211: 198-205
13. Richard J Johnson, John Feehally: Comprehensive Clinical
Nephrology (2nd). Mosby, 2003; 835-841
14. Tank JE, Vora JP, Houghton DC, Anderson S: Altered renal vascular
responses in the aging rat kidney. Am J Physiol 1994; 266 (6 Pt 2):
942-948
15. Epstein M: Aging and the kidney. J Am Soc Nephrol 1996; 7 (8):
1106-1122
16. Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW: The effect
of age on creatinine clearance in men: A cross-sectional and
longitudinal study. J Gerontol 1976; 31 (2): 155-163
17. Lindeman RD, Goldman R: Anatomic and physiologic age changes
in the kidney. Exp Gerontol 1986; 21 (4-5): 379-406
18. Jones CA, Francis ME, Eberhardt MS, Chavers B, Coresh J,
Engelgau M, Kusek JW, Byrd-Holt D, Narayan KM, Herman
WH, Jones CP, Salive M, Agodoa LY: Microalbuminuria in the
US population: Third National Health and Nutrition Examination
Survey. Am J Kidney Dis 2002; 39 (3): 445-459
19. Luft FC, Grim CE , Gineberg N, Wienberger MC: Effects of volume
expansion and contraction in normotensive whites, blacks and
subjects of different ages. Circulation 1979; 59: 643-650
20. Epstein M, Hollenberg NK: Age as a determinant of renal sodium
conservation in normal man. J Lab Clin Med 1976; 87 (3): 411-417
21. Weinberger MH, Fineberg NS: Sodium and volume sensitivity of
blood pressure. Age and pressure change over time. Hypertension
1991; 18 (1): 67-71
22. Streeten DH, Anderson GH Jr, Wagner S: Effect of age on response
of secondary hypertension to specifi c treatment. Am J Hypertension
1990; 3: 360-365
23. Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS: Prevalence of
chronic kidney disease and decreased kidney function in the adult
US population. Third National Health and Nutrition Examination
Survey. Am J Kidney Dis 2003; 41: 1-12
24. Glassock RJ: Glomerular disease in t he elderly population. In
Oreopoulos DG, Hazzard WR, Luke R (eds): Nephrology and
Geriatrics Integrated. Dordrecht, Kluwer Academic Publishers,
2000; 57-66
25. Vendemia F, Gesualdo L, Schena FP, D’Amico G; Renal
Immunopathology Study Group of the Italian Society of Nephrology;
Epidemiology of primary glomerulonephritis in the elderly. Report
from the Italian Registry of Renal Biopsy. J Nephrol 2001; 14 (5):
340-352
26. Vassallo M, Shepherd RJ, Iqbal P, Feehally I: Age-related variations
in presentation and outcome in Wegener’s granulomatosis. J R Coll
Physicians Lond 1997; 31 (4): 396-400
27. Burstein DM, Korbet SM, Schwartz MM: Membranous
glomerulonephritis and malignancy. Am J Kidney Dis 1993; 22:
5-10
28. Wiggins J: Geriatrics. Am J Kidney Dis 2005; 46 (1): 147-158
29. Pascual J, Liano F, Ortuno J: The elderly patient with acute renal
failure. J Am Soc Nephrol 1995; 6: 144-153
30. Liano F, Pascual J: The Madrid Acute Renal F ailure Study Group.
Epidemiology of acute renal failure: A prospective, multicenter,
community based study. Kidney Int 1996; 50: 811-818
31. Preston RA, Stemmer CL, Materson BJ, Perez-Stable E, Pardo V:
Renal biopsy in patients 65 years of age or older. An analysis of the
results of 334 biopsies. J Am Geriatr Soc 1990; 38 (6): 669-674
32. Haas M, Spargo BH, Wit EJ, Meehan SM: Etiologies and outcome
of acute renal insufficiency in older adults: A renal biopsy study of
259 cases. Am J Kidney Dis 2000; 35: 433-447
33. Davison AM: Renal disease in the elderly. Nephron 1998; 80: 6-16

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