DRUG-EXCIPIENTS INTERACTION AND SOLUBILITY ENHANCEMENT STUDY OF SIMVASTATIN

Aim: The purpose of the present study is drug polymer interaction of drug Simvastatin (SV) with different polymers like Chitosan, glycin and beta cyclodextrin(P-CD), were tested analytically and comparison of the results was done and report any possible interactions between them. Previously it was reported that SV forms inclusion complexes with P- Cyclodextrin (P¬ CD) thereby increasing the solubility of SV in water and this is confirmed here in the present study by use of phase solubility studies and aqueous solubility. Method: The analytical techniques used for the purpose are Fourier Transform Infrared Spectroscopy (FTIR) and Differential scanning calorimeter (DSC) to characterize any drug-polymer interactions and formation of inclusion complex. The complexes were prepared by simple Kneading techniques and were evaluated for phase solubility and aqueous solubility. Result: The FTIR and DSC study indicate no interaction occurs between drug- polymers and revealed that no endothermic and characteristic diffraction peaks of SV was observed in the inclusion complexes. The study indicated the conversion of crystalline form of SV into the amorphous form. Aqueous solubility profiles were markedly increased in inclusion complexes, compared with the drug alone and physical mixture this study is done so that future formulations can be prepared based on these results. Conclusion: Simvastatin is compatible with polymers and solubility of drug was increase by formation of inclusion complex with beta cyclodextrin (P-CD). Available Online