Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
Abstract (2. Language):
An attempt was to formulate Pharmaceutical equivalent bilayer
tablet of Anti-diabetic by using the wet granulation method. In this
formula one layer provide the loading dose by immediate drug
release and another layer provide maintenance dose up to 10 hrs by
extended release. The drug excipient computability study was
carried out with FTIR study, there was no interaction found.
Immediate release fraction was formulated by using cross
carmellose sodium (CCS) as a disintegrating agent and sustained
release fraction was formulated by using hydroxy propyl methyl
cellulose (HPMC) as a rate controlling polymer. The granules were
evaluated for angle of repose, bulk density, tapped density and
compressibility index showed satisfactory results. The prepared
bilayer tablets were evaluated as thickness, hardness, friability and
in-vitro release studies. In-vitro dissolution study was carried out for
10 hrs using USP dissolution apparatus type II with 0.1 N HCl and 6.8
pH phosphate buffer as dissolution medium. From the Kinetic study
of dissolution profile all batches were depicted for release
mechanism of sustained release. Stability study was carried out for
the optimized formulation at 40°C/75% RH for 1 month, the result
shows that there was no significant change in physical and chemical
parameter of the tablet.
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FULL TEXT (PDF):
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