Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
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Abstract (2. Language):
Background: Microbial resistance to drugs has become a global publichealth
problem compromising the efficacy of antimicrobial
chemotherapy. The phenomenon of drug resistance is not restricted to
pathogenic bacteria; it also involves the commensal microbiota of
humans. There is worldwide concern about the spread of antibiotic
resistant microbiota causes of community as well as hospital acquired
infections. Methods: This prospective study comprising of 100 faecal
samples were processed and the isolates were identified by using
standard microbiological techniques and antibiotic sensitivity was
determined by Kirby Bauer disc diffusion method. Result: Out of 100
samples 50 were from community and 50 from hospital patients. In this
study it was noted that the antibiotic resistance was more in hospital
patients than in healthy individuals of community. The resistance
patterns of hospital patients and healthy individuals of community as
follows ampicillin, 68% and 36%; amoxyclav, 66% and 18%; ciprofloxacin,
56% and 18%; co-trimoxazole, 54% and 22%; cefotaxime, 50% and 10%;
gentamicin, 30% and 4%; piperacillin-tazobactum, 30% and 0%;
cefaparazone-sulbactum, 24% and 0%; amikacin, 14% and 0%; imipenem,
12% and 2% of the tested isolates, respectively. Conclusion: It can be
concluded that faecal carriage of antibiotic resistant E. coli can causes of
hospital-acquired infections and occasionally causes community-acquired
infections. So, it is recommended that it necessitates prevention of
infections by conducting the infection control programmes and
implementation of surveillance for this emerging antibiotic resistance
phenomenon.
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FULL TEXT (PDF):
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283-289