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ERİTROPOETÎN TEDAVİSİ ALAN ÇOCUK PERİTON DİYALİZİ HASTALARINDA KARNİTİN SUPPLEMANTASYONU'NUN ANEMİYE ETKİLERİ

CARNITINE AFFECTS ON ANEMIA IN PEDIATRIC PATIENTS ON PERITONEAL DIALYSIS TREATED WITH ERYTHROPOIETIN

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Therapy of the anemia is a serious problem in patients with chronic renal failure. Several reports on adult patients have shown that supplementation with L-carnitine can decrease the requirement for rhEPO. We investigated this subject in 20 children on peritoneal dialysis with a median age of 11.2 years. After obtaining baseline data, all children were supplemented with L-carnitine 50 mg/kg/day. At baseline, free carnitine levels were lower than that of controls, although total carnitine levels were similar. At the end of the study, total, free and acyl carnitine levels increased while there was no significant change in hemoglobin levels or iron parameters. In conclusion, we could not demonstrate any beneficial effect of supplementation with L-carnitine on hemoglobin or iron parameters in children on peritoneal dialysis.
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Abstract (Original Language): 
Anemi, kronik böbrek yetmezliği olan hastalarda en önemli tedavi problemlerinden biridir. Erişkin hastalarda yapılan çalışmalar, karnitin suplemantasyonu ile rekombinant insan eritropoetinine (rhEPO) olan ihtiyacın azaltılabileceğini göstermiştir. Yaş ortalaması 11.2 olan ve periton diyalizi tedavisi gören 20 çocuk hastada bu konuyu araştırdık. Bazal verilerin alınmasından sonra hastalara 50 mg/kg/gün dozunda karnitin suplemantasy onuna başlandı. Bazal olarak, hasta ve kontrol gruplarının total karnitin düzeyleri her ne kadar farklı değildiyse de hasta grubunda serbest karnitin düzeyleri düşüktü. Çalışma peryodunun sonunda hastaların total, serbest ve acil karnitin düzeyleri yükselmişti. Buna karşılık, hemoglobin, hematokht veya demir parametrelerinde bir değişiklik olmadı. Sonuç olarak; periton diyalizi tedavisi gören çocuklarda karnitin suplemantasyonu' nun hemoglobin ve demir parametrelerine faydalı bir etkisini gözlemedik.
FULL TEXT (PDF): 
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  • 1
41-47
  • Turkish

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