You are here

Home » Content

MANTAR ZEHİRLENMELERİNDE EKSTRAKORPORAL TEDAVİLER

EXTRACORPORAL TECHNIQUES IN THE TREATMENT OF MUSHROOM POISONING

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Poisoning by cytotoxic mushrooms is associated with severe morbidity and a high mortality rate. Due to the poor knowledge of the pharmacodynamics of toxins, there are conflicting results about appropriate treatment, particularly the efficacy of detoxification. The detoxification treatment should ideally be initiated early to minimize the toxic exposure of highly susceptible cells. Therapeutic strategy comprises elimination methods such as gastrointestinal lavage, charcoal administration, forced diuresis and extracorporeal detoxification techniques. Among these techniques, hemoperfusion and plasmapheresis are the most effective procedures of all. Early and comprehensive treatment are essential.
Bookmark/Search this post with
Abstract (Original Language): 
Sitotoksik mantar zehirlenmeleri ciddi mm-bidite ve yüksek mortalite oranlan ile ortaya çıkmaktadır. Toksinlerin farmakodinamisine ait bilgilerin yetersizliğine bağlı olarak, özellikle detoksifikasyon etkinliği açısından, en uygun tedavi konusunda yanıltıcı sonuçlara ulaşılmıştır. Duyarlılığı yüksek olan hücrelerdeki toksik hasarı en aza indirmek amacıyla, detoksifikasyon tedavisi erken dönemde başlatılmalıdır. Tedavi stratejisini gastrointestinal lavaj, aktif kömür uygulaması, zorlu diürez ve ekstrakorporal detoksifikasyon teknikleri gibi eliminasyon yöntemleri oluşturur. Bu tekniklerin içinde, en etkin olanları hemoperfüzyon ve plazmaferezdir. Erken ve kapsamlı tedavi yaşamsal önem taşır.
FULL TEXT (PDF): 
PDF icon pdf_tndt_317.pdf
  • 1
14-18
  • Turkish

REFERENCES

References: 

1. Doolan PD, Walsh WP, Kyle LH, Wishinsky R: Acetyl salicylic acid intoxication: a proposed method of treatment. JAMA 1951; 146: 105-106.
2. Schreiner GE: The role of hemodialysis in acute
poisoning. Arch intern Med 1958; 102: 896-913.
3. Schreiner GE, Masher JF: The dialysis of poisons. New Jersey Academic Medicine 1960; 6: 310-324.
4. Maher JF, Schreiner GE: Editorial review: the dialysis of poisons. Transactions of the ASAOI 1963; 9: 385¬394.
5. Winchester JF, Gelfand MC, Krepshield JH, Schreiner GE: Dialysis and hemoperfusion of poisons and drugs-update. Transactions ofthe ASAOI 1977; 23: 762-842.
6. Seyffart G: Dialysis and hemoperfusion treatment of acute poisoning. In Oxford Textbook of Clinical Nephrology, eds. Davison AM, Cameron IS et al. Oxford University Press Inc. New york, pp: 1609-1623,
1998.
7. Litovita TL, Felberg L, Soloway RA, Ford M, Geller R:
1994 annual report of the American association of Poison Control Centers National Data collection System. American Journal of Emergency Medicine
1995, 13; 551.
8. Olsen KR, Pond SB, Seward J: Amanita phalloides-type
mushroom poisoning. West J Med 1982; 137: 282-289.
9. Mitchel DH: Amanita mushroom poisoning. Annu Rev
Med 1980;31:51-57.
10. Wieland T, Faulstick H: Amatoxins, phallotoxins, phallolysin and antamanide: The biologically active components of poisonous amanita mushrooms. CRC
Crit Rev Biochem 1978; 5: 185-260.
11. Beutler JA, Vargeer PP: Amatoxins in American mushrooms. Evaluation of the Meixner test. Mycologia
1980; 72: 1142-1149.
12. Logarenger A, Tuchweber B, Gicquaaud C: Toxicity of peptides of Amanita virosa mushrooms in mice.
Fundam appl Toxicol 1985; 5: 1144-1152.
13. Kisilevsky R: hepatic nuclear and nucleolar changes in
Amanita poisoning. Arch Pathol 1974; 97: 253-258.
14. Busi C, Fiume L, Costantino D: Amanita toxins in gastroduodenal fluid of patients poisoned by the mushroom Amanita phalloides. N Eng J Med 1979;
300: 800.
15. Faulstich H: New aspects of Amanita poisoning. Klin
Nochenschr 1979; 57: 143-152.
16. Belliardo F, Massano G, Accomo S: Amatoxins do not cross the placental barrier. Lancet 1983; 1: 1381.
17. Bartoloni DT, Omer F, Giannini A: Amanita poisoning: A clinical-histopathological study of 64 cases of intoxication. Hepatogastroenterology, 1985 32: 229¬231.
18. Myler RK, Lee JC, Hopper J: Renal tubular necrosis caused by mushroom poisoning. Arch Intern Med 1964;
114: 196-204.
19. Pond SM, Olsan KR, Woo OF: Amatoxin poisoning in Northern California 1982-1983. West J Med 1986; 145: 204-209.
20. Costantino D, Damia G: Phalloidine intoxication. Results of various forms of treatment in 47 patients.
Nouv Presse Med 1977; 26: 2315-2317.
21. Ghiringhelli L, Ceriani A, Lepore G, Moda S: Phallin syndrome. Reports on 28 cases. Minerva Med 1981; 37: 2499-2508.
22. Langer M, Vesconi S, lapichino G, Costantino D, Radrizzani D: The early removal of amatoxins in the treatment of amanita phalloides poisoning. Klin
Wochenschr 1980; 58: 117-123.
23. Vesconi S, Langer M, lapichino G, Costantino D, Busi C, Fiume L: Therapy of cytotoxic mushroom
intoxication. Crit Care Med 1985; 13: 402-406.
24. Abel JJ, Rowntree LG, Turner BB: On the removal of diffusible substances from the circulating blood by means of dialysis. Transactions of the Association of American Physicians 1913; 28: 51.
25. Sargent JA, Gotch FA: Principles and biophysics of dialysis. In Replacement of Academic Publishers,
Dordrecht, pp: 87-143, 1989.
26. de Haro L, Jouglard J, Arditti J, David JM: Acute renal insufficiency caused by Amanita proxima poisoning: experience of the poison Center of Marbeille.
Nephrologie 1998; 19:21-24.
27. Leray H, Canaud B, Andry C, Klouche K, Beraud JS, Mion C: Amanita proxima poisoning: a new cause of acute renal insufficiency. Nephrologie 1994; 15: 197¬199.
28. Kohn R, Motovska Z: mushroom poisoning, classification, symptoms and therapy. Vnitr Lek 1997;
43: 230-233.
29. Holal B, Regele H, Kirchmair M, Sandhofer F: Acute renal failure after ingestion of Cortinarius
speciosissimus. Clin Nephrol 1997; 48: 260-262.
30. Rohrmoser M, Kirchmair M, Feifel E, Valli A, Corradini R, Pohanka E, Rosenkranz A, Poder R: Orellanine poisoning: rapid detection of the fungal toxin in renal biopsy material. J Toxicol Clin Toxicol
1997;35:63-66.
17
31. Holmdahl J. Blohme I: Renal transplantation after Cortinarius speciosissimus poisoning. Nephrol Dial Transplant 1995; 10: 1920-1922.
32. Muirhead EE, Reid AF: Resin artificial kidney. J Lab Clin Med 1948;33:841-844.
33. Yatzidis H: A convenient hemoperfusion microapparatus over charcoal for the treatment of exogenous and endogenous intoxications. Its use as an artificial kidney. Proceeding of the EDTA 1964; 1:83.
34. Yatzidis H. Oreopulos D, Triantaphylidis D, Voudiclaris S, Tsaparas N, Gauraa H: Treatment of severe barbiturate poisoning. Lancet 1965; ii: 216-217.
35. Rosenbaum JL, Winsten S, Kramer MS, Moros J, Raja R: Resin hemoperfusion in the treatment of drug intoxication. Transactions of the AS AIO 1970; 16: 134.
36. Mydlik M, Derzsiova K, Mizla P, Bero P:
Hemoperfusion in mushroom poisoning. Clinical analysis of 58 patients. Cas Lek Cesk 1993: 132: 464¬467.
37. Mydlik M, Derzsiova K. Klan J. Zima T:
Hemoperfusion with alpha-amanitin: an in vitro study.
Int J Artif Organs 1997; 20: 105-107.
38. Faulstich H, Talas A, Wellhoner HH: Toxicokinetics of labeled amatoxins in the dog. Arch Toxicol 1985; 56: 190-194.
39. Monhart V: Amanita poisoning and the importance of sorption hemoperfusion in its therapy. Vnitr Lek 1997;
43: 686-690.
40. Monhart V, Balikova M, Tlustakova M: The sorption effectiveness of Czech-manufactured hemoperfusion sorbents for amatoxins. Cas Lek Cesk 1994; 133: 181¬183.
41. Splendiani G, Zazzaro D, Di Pietrantonio P, Delfino L: Continuous renal replacement therapy and charcoal plasmaperfusion in treatment of amanita mushroom-
poisoning. Artif Organs 2000; 24: 305-308.
42. Verpooten GA, Broe ME: Combined hemoperfusion-hemodialysis in severe poisoning: Kinetics of drug
extraction. Resuscitation 1984; 11: 275-289.
43. Russo GE, Giusti S, Maurici M, Bosco M, Vitalino E,
Caramiclo MS, Bauco B, De Marco CM, Marigliano V: Plasmapheresis and mushroom poisoning: report of a case of Amanita phalloides poisoning: Clin Ter 1997;
148:277-280.
44. Chaiear K, Limpaiboon R, Mecchai C, Poovorawan Y: Fatal mushroom poisoning caused by Amanita virosa in Thailand. Southeast Asian J Trop Med Public Health
1999; 30: 157-160.
45. Jander S, Bischoff J: Treatment of amanita phalloides poisoning: Retrospective evaluation of plasmapheresis
in 21 patients. Ther Apher 2000; 4: 303-307.
46. Jander S, Bischoff J, Woodcock BG: Plasmapheresis in the treatment of amanita phalloides poisoning: A rewiev and recommendations. Ther Apher 2000; 4: 308-312.

Thank you for copying data from http://www.arastirmax.com