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HEMODİYALİZ HASTALARINDA SERUM ÇİNKO VE BAKIR DÜZEYLERİNİN İNCELENMESİ

THE EVALUATION OF SERUM ZINC AND COPPER LEVELS IN THE HEMODIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Our purpose was to determine serum zinc (Zn) and copper (Cu) levels in patients with chronic renal failure (CRF) undergoing (HD) and to investigate the effects of dialysis duration of time on these trace elements. This study included 26 HD patients (17 Male and 9 Female) who were treated in HD Center of Dicle University Hospital and 26 healthy subjects (13 Male and 13 Female) as control group. Three blood samples were taken from all cases to determine serum Zn and Cu levels, biochemical tests and CBC. Serum Zn and Cu levels were analysed by AAS (Unicam 929). Patients were between 18 and 67 years (mean age, 43^15years) in HD group and between 20 and ~0 years (mean age, 4017 years) in control group. The laboratory finding showed the following mean values Zn, 69.6±17.6 g/dl; Cu, 85.3±14.8 g/dl in HD patients and Zn, 114.9±34.3 g/dl; Cu, 161.2±49.3 g/dl in control group, respectively. Serum Zn and Cu levels of HD patients were significantly lower than control group (p<0.0001). Statistically, we didn't find any significant differences in serum Zn and Cu levels between long-term and short-term dialysed patients (p>0.05). In HD patients, serum Zn and Cu levels, but especially Zn levels were found significantly to be decreased. We especially recommend that Zn should be given to patients with CRF undergoing HD and to protein-restricted CRF patients.
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Abstract (Original Language): 
Bu çalışmada, Kronik böbrek yetmezlikti (KBY) hemodiyaliz (HD) hastalarında, serum çinko (Zn) ve bakır (Cu) düzeylerini belirlemeyi ve diyaliz süresinin bu eser elementler üzerine olan etkisini araştırmayı amaçladık. Çalışma, Dicle Üniversitesi Hastanesi Hemodiyaliz Ünitesinde tedavi edilen 26 hasta (17'si erkek, 9 'u kadın) ile kontrol grubu olarak, 26 sağlıklı (13 ü erkek, 13 ü kadın) gönüllüyü kapsamaktaydı. Bu hastalardan serum Zn ve Cu düzeyleri, biyokimyasal tetkikler ve kan sayımı için 3 'er adet serum örneği alındı. Serum Zn and Cu düzeyleri AAS (Unicam 929) ile ölçüldü. HD grubunda, hastaların yaşları 20-70 arasında değişmekte olup, ortalama yaş 40±I 7, kontrol grubunun ise yaşları 18-67 arasında olup, ortalama yaş 43±15 'idi. HD hastalarında serum Zn düzeyi 69.6±17.6 g/dl, Cu düzeyi 85.3±14.8g/dl, kontrol grubunda Serum Zn düzeyi 114.9^34.3g/dl, Cu düzeyi 161.2±49.3g/dl bulundu. Serum Zn ve Cu düzeyleri kontrol grubuna göre HD'e giren KBY hastalarında belirgin olarak düşüktü (p<0.0001). HD süre ve seans sayısına göre serum Zn ve Cu düzeylerinde istatistiksel olarak anlamlı farklılık saptanmadı (p>0.05). HD hastalarında serum Zn ve Cu düzeyleri, özelliklede Zn düzeyleri belirgin olarak düşük bulunmuştur. Sürekli HD tedavisi alan ve proteini kısıtlanan hastalara özellikle Zn verilmesini öneriyoruz.
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  • 2
79-83
  • Turkish

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