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SİGARANIN MİNE MATRİKS PROTEİNLERİ VE BİYOAKTİF CAM ESASLI VEYA SIĞIR KAYNAKLI KEMİK GREFT MATERYALİ KOMBİNASYONLARI ÜZERİNE ETKİLERİ

EFFECT OF SMOKING ON ENAMEL MATRIX PROTEINS IN COMBINATION WITH BIOACTIVE GLASS OR BOVINE DERIVED XENOGRAFT

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2011

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aim of this study was to evaluate the effect of smoking following regenerative periodontal treatment in generalized aggressive periodontitis patients with, enamel matrix derivative (EMD) combined with a bovine derived xenograft (BDX)(EMD+BDX) or EMD combined with a bioactive glass (BG)(EMD+BG). Twenty patients 10 smokers, 10 non-smokers were included. Intrabony defects with probing depth (PD) of > 5 mm and intrabony component of > 3 mm were treated either with EMD+BDX or EMD+BG. Clinical and radiographical parameters were recorded prior to surgery and 8 months after treatment. At 8 months, in the EMD+BDX and EMD+BG groups, smokers showed 3.09+1.18 mm and 3.16+0.96 mm PD reduction, 1.93+0.64 mm and 1.86+0.72 mm attachment gain, 1.24+0.33 mm and 0.92+0.31 mm clinical bone gain, 0.58+0.31mm and 0.59+0.80 mm radiographic bone gain, respectively. On the other hand, non-smokers showed 3.55+1.07 mm and 3.43+1.30 mm probing depth reduction, 2.17+0.61 mm and 2.0+0.69 mm attachment gain, 1.29+0.31 mm and 1.20±0.25 mm clinical bone gain, 0.69±0.37 mm and 0.60±0.75 mm radiographic bone gain, respectively. Intergroup differences were found to be insignificant. Within its limits, it can be concluded that smoking does not affect the regenerative treatment outcomes in intrabony defects treated with EMD+BDX and EMD+BG:
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Abstract (Original Language): 
Bu çalışmada, sigaranın, mine matriks proteinleri (MMP) ve biyoaktif cam esaslı (BC) veya sığır kaynaklı kemik greft (SKKG) materyali ile kombine kullanımı üzerindeki etkisinin değerlendirilmesi amaçlandı. Çalışmaya 10 sigara içen 10 sigara içmeyen 20 generalize agresif periodontitis hastası dahil edildi. Her hastada MMP+BC ve MMP+SKKG kombinasyonları sondalama derinliği (SD) > 5 mm ve kemik içi defekt derinliği > 3 mm olan kemik içi defektlere uygulandı. Klinik ve radyografık değerlendirmeler operasyondan önce ve operasyon sonrası 8. ayda yapıldı. Defektin en derin noktasında, sigara içen bireylerde, MMP+BC ve MMP+SKKG gruplarında sırasıyla, 3.16+0.96 mm ve 3.09+1.18 mm SD azalması, 1.86 ±0.72 mm ve 1.93+0.64 mm ataşman kazancı, 0.92+0.31 mm ve 1.24+0.33 mm klinik kemik kazancı, 0.59+0.80 mm ve 0.58+0.31 mm radyografık kemik kazancı, sigara içmeyen bireylerde, MMP+BC ve MMP+SKKG gruplarında sırasıyla, 3.43+1.30 mm ve 3.55+1.07 mm SD azalması, 2.0+0.69 mm ve 2.17+0.61 mm ataşman kazancı, 1.20+0.25 mm ve 1.29+0.31 mm klinik kemik kazancı, 0.60+ 0.75 mm ve 0.69+0.37 mm radyografık kemik kazancı elde edildi. Her iki tedavi grubunda da sigara içen ve içmeyen bireyler arasında incelenen parametreler açısından istatistiksel olarak anlamlı bir fark bulunmadı (p>0.05). Bu çalışmanın sınırları dahilinde sigaranın her iki rejeneratif materyal kombinasyonları üzerinde anlamlı bir etkisinin olmadığı sonucuna varılabilir.
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REFERENCES

References: 

1. Armitage GC. Development of classification system for periodontal diseases and conditions. Ann Periodontal, 1999; 4: 1-6.
2. American Academy of Periodontology. Parameter on aggressive periodontitis. J Periodontal, 2000; 71: 867-869.
3. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontal, 2000; 1997, 14: 9-11.
4. Ah MK, Johnson GK, Kaldahl WB, Patil KD, Kalkwarf KL. The effect of smoking on the response to periodontal therapy. J Clin Periodontal, 1994; 21: 91-97.
5. Kinane DF, Radvar M. The effect of smoking on mechanical and antimicrobial periodontal therapy. J Periodontal, 1997; 68: 467-472.
6. Salvi GE, Lawrence HP, Offenbacher S, Beck JD. Influence of risk factors on the pathogenesis of periodontitis. Periodontal 2000, 1997; 14: 173-201.
7. Tonetti MS, Pini-Prato G, Cortellini P. Effect of cigarette smoking on periodontal healing following GTR in infrabony defects. A preliminary retrospective study. J Clin Periodontal, 1995; 22: 229-234.
8. Cattaneo V, Cetta G, Rota C, Vezzo F, Rota MT, Gallanti A, Borrato R, Poggi P. Volatile components of cigarette smoke: effect of acrolein and acetaldehyde on human gingival fibroblasts in vitro. J Periodontal, 2000; 71: 425-432.
9. Sayers NM, James JA, Drucker DB, Blinkhorn AS. Possible potentiation of toxins from
prevotella intermedia, prevotella nigrescens and porphyromonas gingivalis by cotitine. J Periodontal, 1999; 70: 1269-1275.
10. Tanur E, Mc Quade MJ, Mc Pherson JC, Al-Hashimi IH, Rivera-Hidalgo F. Effects of nicotine on strength of attachment of gingival fibroblasts to glass and non-diseased human root surfaces. J Periodontal, 2000; 71: 717-722.
11. Hollinger JO, Schmitt JM, Hwang K, Soleymani P, Buck D. Impact of nicotine on bone healing. J Biomed Mater Res, 1999; 45: 294-301.
12. Mullally BH, Bren B, Linden GJ. Smoking and patterns of bone loss in early- onset periodontitis. J Periodontal, 1999; 70: 394-401.
13. Froum S, Weinberg MA, Tarnow D. A comparison study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects. A 12 month re-entry study. J Periodontal, 2001; 72: 25-34.
14. Heden G. A case report study of 72 consecutive Emdogain-treated intrabony periodontal defects: Clinical and radiographic findings after 1 year. Int J Periodont Rest Dent, 2000; 20: 127-139.
15. Kuru B, Yılmaz S, Argın K, Noyan Ü. Enamel matrix protein derivative alone or combination with bioactive glass in wide intrabony defects. Clin Oral Invest, 2006; 10: 227-234.
16. Vandana KL, Shah K, Prakash S. Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients. Int J Periodontics Restorative Dent, 2004; 24: 185¬191.
17. Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Kenney EB Madzarevic M. The effectiveness of enamel matrix proteins used in combination with bovine porous bone mineral in the treatment of intrabony defects in humans. J Clin Periodontal, 2001; 29: 1016¬1022.
18. Cochran CD, Jones A, Heijl L, Mellonig JT, Schoolfıeld J, King GN. Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting. J Periodontal, 2003; 74: 1269-1281.
19. Döri F, Arweiller N, Gera I, Sculean A. Clinical evaluation of an enamel matrix protein derivative combined with either a natural bone mineral or (3- tricalcium phosphate. J Periodontal, 2005; 76: 2236-2243.
20. Gurinsky BS, Mills MP, Mellonig JT. Clinical evaluation of demineralized freeze-dried bone allograft and enamel matrix derivative versus enamel matrix derivative alone for the treatment of periodontal osseous defects in humans. J Periodontal, 2004; 75: 1309-1318.
21. Lekovic V, Camargo PM, Weinlaender M, Nedic M, Aleksic Z, Kenney EB. A comparison between enamel matrix protein used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in human. J Periodontal, 2000; 71: 1110-1116.
10
Şebnem Dirikan Ipçi, Gökser Çakar Gürlüman, Deniz Berber Noyun, Selçuk Yılmaz
22. Scheyer ET, Velasquez-Plata D, Brunsvold MA, Lasho DJ, Mellonig JT. A clinical comparison of a bovine-derived xenograft used alone and in combination with enamel matrix derivative for the treatment of periodontal osseous defects. J Periodontal, 2002; 73: 423¬432.
23. Sculean A, Barbe G, Chiantella GC, Arweiler NB, Berakdar M, Brecx M. Clinical evaluation of enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans. J Periodontal, 2002; 73: 401-408.
24. Sculean A, Chiantella GC, Windisch P, Gera I, Reich E. Clinical evaluation of an enamel matrix protein derivative (Emdogain) combined with a bovine derived xenograft (Bio-Oss) for the treatment of intrabony periodontal defects in humans. Int J Periodontics Restorative Dent, 2002; 22: 259¬267.
25. Sculean A, Windisch P, Keglevich T, Gera I. Clinical and histologic evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans. Int J Periodontics Restorative Dent, 2005; 25: 139¬147.
26. Sculean A, Pietruska M, Schwartz F, Willershausen B, Arweiler N.B, Auschill TM. Healing of human intrabony defects following regenerative periodontal therapy with an enemal matrix protein derivative alone and combinated with a bioactive glass. J Clin Periodontal, 2005; 32: 111-117.
27. Velasquez-Plata D, Scheyer TE, Mellonig JT. Clinical comparison of an enamel matrix derivative used alone or in combination with a bovine-derived xenograft for the treatment of periodontal osseous defects in humans. J Periodontal, 2002; 73: 433-440.
28. Zucchelli G, Amore C, Montebugnoli L, De Sanctis M. Enamel matrix proteins and bovine porous bone mineral in the treatment of intrabony defects: A comparative controlled clinical trial. J Periodontal, 2003; 74: 1725¬1735.
29. Yılmaz S, Çakar G, Yıldırım B, Sculean A. Healing of two and three wall intrabony periodontal defects following treatment with an enamel matrix derivative combined with autogenous bone. J Clin Periodontal, 2010; 544-550.
30. Lovelace TB, Mellonig JT, Meffert RM, Jones AA, Numikoski PV, Cochran DL. Clinical evaluation of bioactive glass in the treatment of periodontal osseous defects in humans. J Periodontal, 1998; 69: 1027-1035.
31. Berglundh T, Lindhe J. Healing around implants placed in bone defects treated with Bio-Oss. An experimental study in the dog. Clin Oral Imp Res, 1997; 8: 117-124.
32. Silness J, Löe H. Periodontal disease in pregnancy (II). Correlation between oral hygiene and periodontal conditioning. Acta Odontologica Scandinavica, 1964; 22: 121¬135.
33. Mühlemann HR, Son S. Gingival sulcus bleeding: a leading symptom in initial gingivitis. Helvetica Odontologica Acta, 1971; 15: 107-112.
34. Schei O, Waerhaug J, Lovdal A, Arro A. Alveolar bone loss as related to oral hygiene and age. J Periodontal, 1959; 30: 7-16.
35. Nery EB, Olson JV, Henkin JM, Halbtleisch JH. Film holder device for radiographic assessment of periodontal tissues. J Periodont Res, 1985; 20: 97-105.
36. Sculean A, Windisch P, Keglevich T, Fabi B, Lundgren, E, Lyngstadaas PS. Presence of an enamel matrix protein derivative on human teeth following periodontal surgery. J Clin Oral Invest, 2002; 6: 183-187.
37. Wilson J, Pigott GH, Schoen FJ, Hench LL. Toxicology and biocompatibility of bioglasses. J Biomed Material Research, 1981; 15: 805¬817.
38. Zamet JS, Darbar UR, Griffhiths S, Bulman JS, Bragger U, Burgin W, Newman HN. Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects. J Clin Periodontal, 1997; 24: 410-418.
39. Mellonig JT. Human histologic evaluation of a bovine derived xenograft in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent, 2000; 20: 19-29.
40. Camelo M, Nevins ML, Lynch SE, Schenk RK, Simion M, Nevins M. Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane. Int J Periodont Rest Dent, 2000; 21: 109-119.
41. Calsina G, Ramon JM, Echeveria JJ. Effects of smoking on periodontal tissues. J Clin Periodontal, 29: 771-776, 2002.
Sigaramn Mine Matriks Proteinleri ve Biyoaktif Cam Esaslı veya Sığır Kaynaklı Kemik Greft Materyali Kombinasyonları Üzerine EtkileriW
42. Heard RH, Mellonig JT, Brunsvold MA, Lasho DJ, Meffert RM, Cochran DL. Clinical evaluation of wound healing following multiple exposures to enamel matrix protein derivative in the treatment of intrabony defects. J Periodontal, 2000; 71: 1715-1721.
43. Spahr A, Lyngstaads SP, Boeckh C, Andersson C, Podbielski A, Haller B. Effect of the enamel matrix derivative (Emdogain) on the growth of periodontal pathogens in vitro. J Clin Periodontal, 2002; 29: 2-72.
44. Silverstein P. Smoking and wound healing. Am J Med, 93:22-24, 1992.
45. Bosshardt DD. Biological mediators and periodontal regeneration: A review of enamel matrix proteins at the cellular and molecular levels. J Clin Periodontal, 35: 87-105, 2008.
46. Renvert S, Garret S, Nilveus R, Chamberlain A.D, Egelberg J. Healing after treatment of periodontal intraosseous defects. VI. Factors influencing the healing response. J Clin Periodontal, 1985; 12: 707-715.

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