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FORMULATION DEVELOPMENT AND CHARACTERIZATION OF FLOATING MICROSPHERES OF GABAPENTIN

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
Gastro retentive systems can stay in the gastric region for more than a few hours and hence prolongs the gastric residence time of drugs. The current research work was an endeavor to formulate and evaluate gastroretentive floating drug delivery system containing gabapentin in the form of microspheres to prolong its gastric residence time in stomach. Floating microspheres was formulated using biocompatible polymers like Eudragit S100 and Ethyl cellulose in different proportions by solvent evaporation technique. The floating microspheres were characterized by % yield, particle size analysis, drug entrapment efficiency, surface topography, buoyancy percentage, in-vitro drug release was studied for 12 hour and scanning electron microscopy. Accelerated stability study was also performed for three months indicated that optimized formulation was stable. The floating microspheres showed better result and it may be use full for prolong the drug release in stomach and improve the bioavailability. Practical yield of the microspheres was up to 75.40%. The formulated microspheres were free flowing with good packing properties. Scanning electron microscopy confirmed spherical structure and the particles were of the size range of 57.67 to 92.20μm. The microspheres with Ethyl cellulose showed higher buoyancy when compared with Eudragit S-100. All formulation showed good in vitro percent buoyancy. In vitro release studies showed cumulative % drug release between 74.95-87.25%. In vitro release studies demonstrated non-Fickian diffusion of drug from the microsphere.
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REFERENCES

References: 

1. Y. S. Tanwar, P. S. Naruka, G. R. Ojha. Development
and evaluation of floating microspheres of
verapamil hydrochloride, Brazilian J Pharm Sci.
43(4): 529-34 (2007).
2. Z. Rahman, M. Ali, R. K. Khar. Design and evaluation
of bilayer floating tablets of captopril, Acta Pharm.
56(1): 49-57 (2006).
3. R. K. Khar, S. P. Vyas. Targeted and controlled drug
delivery novel carrier system, CBS Publishers and
Distributors, New Delhi, 2002, 1st ed., pp. 417- 441.
4. S. Arora, J. Ali, A. Ahuja, R. K. Khar. and S. Baboota.
Floating Drug Delivery Systems: A Review, AAPS
PharmSciTech, 6 (3): 372-390 (2005).
5. K. D. Tripathi. Essentials of Medical Pharmacology,
5th Edn, New Jaypee Brothers, Delhi 2003.
Devesh Kapoor et al., ARPB, 2013; Vol 3 (III) ISSN 2250-0774
(RESEARCH ARTICLE)
450 | P a g e w w w . a r p b . i n f o
6. Goodman and Gilman. The Pharmacological Basis of
Therapeutics, 11th Edn. McGraw-Hill, New York,
2006.
7. R. B. Umamaheshwari, S. Jain, D. Bhadra, N. K. Jain.
Floating microsphere bearing acetohydroxamic acid
for treatment of H. pylori, J Pharm Pharmacol
55(12): 1607-13 (2003).
8. M. R. P. Rao, S. G. Borate, K. C. Thanki, A. A. Ranpise,
G. N. Parikh. Development and in vitro evaluation of
floating rosiglitazone maleate microspheres, Drug
Development and Industrial Pharmacy, 35(7): 834–
842 (2009).
9. M. Saravanan, M. D. Dhanaraju, S. K. Sridhar, S.
Ramachandran, S. K. G. Sam, P. Anand, K. Bhaskar,
G. S. Rao. Preparation, characterization and in vitro
release kinetics of ibuprofen polystyrene
microspheres, Indian J Pharm Sci. 66 (3): 287-92
(2004).
10. A. Patel, S. Ray, R. S. Thakur. In vitro evaluation and
optimization of controlled release floating drug
delivery System of metformin hydrochloride, DARU
14(2): 57-64 (2006).
11. A. H. El-Kamel, M. S. Sokar, S. S. Al Gamal, V. F.
Naggar. Preparation and evaluation of ketoprofen
floating oral delivery system, Int J Pharm. 220 (1-2):
13-21 (2001).
12. A. K. Jain, C. P. Jain, Y. S. Tanwar, P. S. Naruka.
Formulation, characterization and in vitro
evaluation of floating microspheres of famotidine as
a gastro retentive dosage form, Asian J Pharm. 3(3):
222-6 (2009).
13. N. Ma, L. Xu, Q Wang, X Zhang, W Zhang, Y. Li, L. Jin,
S. Li. Development and evaluation of new sustainedrelease
floating microspheres, Int J Pharm. 358(1-
2): 82-90 (2008).
14. S. P. Bharate, Y. S. Rupnvar, R. M. Sonvane, K. R.
Pawar, R. P. Rahane. Formulation and evaluation of
floating microspheres of ketrolac trometamol,
International journal of pharmaceutical research
and development online 1(9): 1-8 (2009).
15. P. Trivedi, A. M. L. Verma, N. Garud. Preparation and
characterization of aceclofenac microspheres, Asian
journal of pharmaceutics 110-115 (2008).
16. Y. Sato, Y. Kawashima, H. Takeuchi, H. Yamamoto. In
vitro evaluation of floating and drug releasing
behaviour of hollow microsphers (microballoons)
prepared by emulsion solvent diffusion method,
European journal of pharmaceutics and
biopharmaceutics 57: 235–243 (2004).
17. J. Varshosaz, M. Tabbakhian, M. Zahrooni.
Development and Characterization of floating
microballoons for oral delivery of cinnarazine by a
factorial design, Journal of microencapsulation 24
(3): 253–262 (2007).
18. A. K. Srivastava, D. N. Ridhurkar, S. Wadhwa.
Floating microspheres of cimetidine: formulation,
characterization and in vitro evaluation, Acta
Pharm. 55(3): 277- 85 (2005).
19. M. A. Altaf, Sreedharan, N. Charyulu. Ionic gelation
controlled drug delivery systems for gastricmucoadhesive
microcapsules of captopril, Indian J
Pharm Sci. 70(5): 655-8 (2008).
20. R. D. Kale, P. T. Tayade. A multiple unit floating
drug delivery system of piroxicam using eudragit as
polymer, Indian journal of pharmaceutical sciences
120-123 (2007).

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