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Fibromiyaljili Kadın Hastalarda Essitalopram İle Gabapentin Tedavilerinin Karşılaştırılması

Comparison of Escitalopram and Gabapentin Treatment in Female Patients With Fibromyalgia

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Abstract (2. Language): 
The aim of this study is to compare the efficacy and safety of escitalopram and gabapentin in patients with fibromyalgia. Eightyeight female patients with fibromyalgia were included in the study. Patients were randomly divided into two groups. Gabapentin (1800 mg/day) was given to first group (n=41 patients), and escitalopram (10mg/day) was given to second group (n=47 patients) for 12 weeks. Patients were evaluated by the same observer for pain, fatique,sleep disorder, depression and health quality at baseline and after the treatment. Pain, fatique and sleep disorders were measured with visual analog scale (VAS), depression was evaluated by Beck Depression Scale (BDS) and health-related quality of life was evaluated with Fibromyalgia Impact Questionnarie (FIQ). Both gabapentin and escitalopram were associated with significant improvements in scores on the pain, fatique,sleep disorder VAS, BDS and FIQ (p<0,05). Escitalopram treated patients displayed a significantly greater improvement in BDS than gabapentin treated patients (p<0,05). Both gabapentin and escitalopram are efficacious for the treatment and other symptoms associated with fibromyalgia. Escitalopram is more preferable in the patients with more depressive symptoms.
Abstract (Original Language): 
Bu çalışmanın amacı fibromiyaljili kadın hastalarda essitalopram ve gabapentinin etkinliği ve güvenilirliğini karşılaştırmaktır. Fibromiyalji tanısı konan 88 hasta randomize olarak iki gruba ayrıldı. 41 kişiden oluşan birinci gruba 1800 mg/gün gabapentin, 47 kişiden oluşan ikinci gruba ise 10 mg/gün essitalopram 12 hafta süreyle verildi. Başlangıçta ve çalışmanın sonunda hastalar ağrı, yorgunluk ve uyku bozukluğu (vizüel analog skala:VAS), depressif durum (Beck Depresyon Ölçeği:BDÖ) ve sağlıkla ilişkili yaşam kalitesi (Fibromiyalji Etkilenme Anketi:FEA) açısından değerlendirildiler. Oniki haftanın sonunda her iki grupta da ağrı, yorgunluk ve uyku bozukluğu VAS, BDÖ ve FEA skorları başlangıca göre istatistiksel olarak anlamlı derecede azaldı (p<0,05). İki grup birbiriyle karşılaştırıldığında, essitalopram kullanan grupta BDÖ’deki düzelme gabapentin grubuna göre daha belirgin idi (p<0,05). Hem gabapentin, hem de essitalopram fibromiyaljide ve eşlik eden semptomların tedavisinde etkilidir. Depresif semptomların ön planda olduğu hastalarda essitalopram tercih edilebilir.
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