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Cytogenetic Effects of Ranitidine on Stem Cell L-Asparaginase Treated Mice

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Abstract (2. Language): 
This study was established to investigate the cytogenetic effects of Ranitidine (RNT) on mice bone marrow stem cells with, before and after L-asparaginas (ASNase) enzyme chemotherapy. The negative control group was injected with 0.2 ml distilled water only for 24 hours, while drugs controls groups consists of RNT controls groups; was given (2 mg/kg or 4 mg/kg) RNT for 24 hours; and ASNase controls groups; was given 1000 U/kg ASNase for 24 hours. Furthermore, three combinations of RNT/ASNase were given at different exposure time. The results revealed appearance cytogenetic effects at (p<0.05) following treatments with RNT and ASNase. Both dosage of RNT caused wide genetic damage compared with other treatment groups. The combination between ASNase and RNT demonstrated appearance cytogenetic effects on mice bone marrow. This study concluded also that combination between RNT and ASNase have positive impact by reduce the aggressiveness of RNT on stem cells and enhancement the ASNase activity as a drug.
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