Gallstone Formation Prophylaxis after Bariatric Surgery: Experience in Saudi Arabia

[1] Mofti, Adnan B., and Mervat S. Al-Saleh. “Bariatric surgery in Saudi Arabia.” Annals of Saudi Medicine Vol.
12, No. 5, 1992, pp. 440-45.
[2] Farsi, Deema J, et al. “Prevalence of obesity in elementary school children and its association with dental caries.”
Saudi Medical Journal Vol. 37, No. 12, 2016, pp. 1378-85.
[3] Al-Agha AE, Alnawab AM, Hejazi TM. “Diverse etiology of hyperlipidemia among hospitalized children in
Western region of Saudi Arabia.” Saudi Medical Journal Vol. 37, No. 11, 2016, pp.1234-38.
[4] Al-Nozha, Mansour M., et al. “Obesity in Saudi Arabia.” Saudi Medical Journal Vol. 26, No. 5, 2005, pp. 824-29.
[5] Al Othaimeen, A.I., M. Al Nozha, and A.K. Osman. “Obesity: An emerging problem in Saudi Arabia. Analysis
of data from the National Nutrition Survey.” 2007.
[6] Al-Daghri, Nasser M., et al. “Diabetes mellitus type 2 and other chronic non-communicable diseases in the central
region, Saudi Arabia (Riyadh cohort 2): A decade of an epidemic.” BMC Medicine Vol. 9, No. 1, 2011, p. 76.
[7] Barrimah, Issam E., Farid Midhat Abdul Rahman Mohaimeed, and Hani A. Al-Shobili. “Prevalence of metabolic
syndrome among qassim university personnel in Saudi Arabia.” International Journal of Health Sciences Vol.
3, No. 2, 2009, p. 133.
[8] El Mouzan, Mohammad I., et al. “Prevalence of overweight and obesity in Saudi children and adolescents.” Annals
of Saudi Medicine Vol. 30, No. 3, 2010, p. 203.
[9] Aldaqal, Saleh M., et al. “Prevalence and desire for body contouring surgery in postbariatric patients in Saudi
Arabia.” North American Journal of Medical Sciences Vol. 4, No. 2, 2012, p. 94.
[10] Erlinger, Serge. “Gallstones in obesity and weight loss.” European Journal of Gastroenterology & Hepatology Vol.
12, No. 12, 2000, pp. 1347-52.
[11] Jeong SU, Lee SK. Obesity and gallbladder diseases. Korean Journal of Gastroenterology Vol. 59, No. 1, 2012,
pp.27-34.
Al-Mutlaq, et al. Int J Med Res Health Sci 2017, 6(12): 27-34
32
[12] Wang, Fei, Bingyuan Wang, and Liang Qiao. “Association between obesity and gallbladder cancer.” Frontiers
in Bioscience Vol. 17, 2012, pp. 2550-58.
[13] Leuratti, Luca. “When small issues can cause big problems: A review of the evidence-based prevention and
treatment of gallstones following bariatric surgery.” International Journal of Gastroenterology Disorders &
Therapy 2014, 2014.
[14] Li, Vicky Ka Ming, et al. “Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk
factors comparing gastric bypass, gastric banding, and sleeve gastrectomy.” Surgical Endoscopy Vol. 23, No. 7,
2009, pp. 1640-44.
[15] Moon, Rena C., et al. “Comparison of cholecystectomy cases after Roux-en-Y gastric bypass, sleeve gastrectomy,
and gastric banding.” Surgery for Obesity and Related Diseases Vol. 10, No. 1, 2014, pp. 64-68.
[16] Deitel, Mervyn, Lloyd Smith, and Athanasios Harmantas. “Laparoscopic cholecystectomy after vertical banded
gastroplasty.” Obesity Surgery Vol. 4, No. 1, 1994, pp. 13-15.
[17] Banim, Paul JR, et al. “Physical activity reduces the risk of symptomatic gallstones: a prospective cohort
study.” European Journal of Gastroenterology & Hepatology Vol. 22, No. 8, 2010, pp. 983-88.
[18] Sugerman, Harvey J., et al. “A multicenter, placebo-controlled, randomized, double-blind, prospective trial of
prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight
loss.” The American Journal of Surgery Vol. 169, No. 1, 1995, pp. 91-97.
[19] Wudel, L. James, et al. “Prevention of gallstone formation in morbidly obese patients undergoing rapid weight
loss: results of a randomized controlled pilot study.” Journal of Surgical Research Vol. 102, No. 1, 2002, pp.
50-56.
[20] Uy, Manley C., et al. “Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a
meta-analysis.” Obesity Surgery Vol. 18, No. 12, 2008, pp. 1532-38.
[21] Holan, Keith R., et al. “Nucleation time: A key factor in the pathogenesis of cholesterol gallstone
disease.” Gastroenterology Vol. 77, No. 4, 1979, pp. 611-17.
[22] Thorlund, Kristian, et al. “Can trial sequential monitoring boundaries reduce spurious inferences from metaanalyses?”
International Journal of Epidemiology Vol. 38, No. 1, 2008, pp. 276-86.
[23] Wetterslev, Jørn, et al. “Estimating required information size by quantifying diversity in random-effects model
meta-analyses.” BMC Medical Research Methodology Vol. 9, No. 1, 2009, p. 86.
[24] De Filippo E, Ferrieri A, Marra M, et al, “Dietetic therapy of obesity: preliminary considerations on the combined
therapy with ursodeoxycholic acid in the prevention of cholesterol lithiasis”. Minerva Medica Vol. 84, 1993, pp.
269-74.
[25] Moran S, Uribe M, Prado ME, et al. “Effects of fiber administration in the prevention of gallstones in obese
patients on a reducing diet: A clinical trial”. Revista de Gastroenterología de México Vol. 62, 1997, pp. 266-72.
[26] Moran, S., et al. “Ref: Gallstone formation in obese subjects undergoing a weight reduction diet.” International
journal of obesity and related metabolic disorders: Journal of the International Association for the Study of
Obesity Vol. 22, No. 3, 1998, p. 282.
[27] Weinsier, Roland L., and Daniel O. Ullmann. “Gallstone formation and weight loss.” Obesity Vol. 1, No. 1,
1993, pp. 51-56.
[28] Gebhard, Roger L., et al. “The role of gallbladder emptying in gallstone formation during diet‐induced rapid
weight loss.” Hepatology Vol. 24, No. 3, 1996, pp. 544-48.
[29] Portenier, Dana D., et al. “Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric
bypass.” Surgery for Obesity and Related Diseases Vol. 3, No. 4, 2007, pp. 476-79.
[30] Warschkow, Rene, et al. “Concomitant cholecystectomy during laparoscopic Roux-en-Y gastric bypass in obese
patients is not justified: A meta-analysis.” Obesity Surgery Vol. 23, No. 3, 2013, pp. 397-407.
[31] Swartz, Daniel E., and Edward L. Felix. “Elective cholecystectomy after Roux-en-Y gastric bypass: why should
asymptomatic gallstones be treated differently in morbidly obese patients?” Surgery for Obesity and Related
Diseases Vol. 1, No. 6, 2005, pp. 555-60.
Al-Mutlaq, et al. Int J Med Res Health Sci 2017, 6(12): 27-34
33
[32] Stokes, Caroline S., et al. “Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight
loss: a meta-analysis of randomized controlled trials.” Clinical Gastroenterology and Hepatology Vol. 12, No.
7, 2014, pp. 1090-1100.
[33] Villegas, Leonardo, et al. “Is routine cholecystectomy required during laparoscopic gastric bypass?” Obesity
Surgery Vol. 14, No. 2, 2004, pp. 206-11.
[34] Taylor, Jerome, I. Michael Leitman, and Michael Horowitz. “Is routine cholecystectomy necessary at the time of
Roux-en-Y gastric bypass?” Obesity Surgery Vol. 16, No. 6, 2006, pp. 759-61.
[35] Hamad, Giselle G., et al. “Elective cholecystectomy during laparoscopic Roux-en-Y gastric bypass: Is it worth
the wait?” Obesity Surgery Vol. 13, No. 1, 2003, pp. 76-81.
[36] Ziegler, O., et al. “Medical follow up after bariatric surgery: Nutritional and drug issues General recommendations
for the prevention and treatment of nutritional deficiencies.” Diabetes & Metabolism Vol. 35, No. 6, 2009, pp.
544-57.
[37] Stokes, Caroline S., et al. “Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight
loss: a meta-analysis of randomized controlled trials.” Clinical Gastroenterology and Hepatology Vol. 12, No.
7, 2014, pp. 1090-1100.
[38] Carey, Martin C. “Critical tables for calculating the cholesterol saturation of native bile.” Journal of Lipid
Research Vol. 19, No. 8, 1978, pp. 945-55.
[39] Weinsier, Roland L., Louis J. Wilson, and Jeannette Lee. “Medically safe rate of weight loss for the treatment
of obesity: a guideline based on risk of gallstone formation.” The American Journal of Medicine Vol. 98, No. 2,
1995, pp. 115-17.
[40] Li, Vicky Ka Ming, et al. “Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk
factors comparing gastric bypass, gastric banding, and sleeve gastrectomy.” Surgical Endoscopy Vol. 23, No. 7,
2009, pp. 1640-44.
[41] Shiffman, M. L., et al. “Gallstones in patients with morbid obesity. Relationship to body weight, weight loss
and gallbladder bile cholesterol solubility.” International Journal of Obesity and Related Metabolic Disorders:
Journal of the International Association for the Study of Obesity Vol. 17, No. 3, 1993, pp. 153-58.
[42] Van De Heijning, Bert JM, et al. “Effects of ursodeoxycholic acid therapy on in vitro gallbladder contractility in
patients with cholesterol gallstones.” Digestive Diseases and Sciences Vol. 44, No. 1, 1999, pp. 190-96.
[43] Broomfield, Paul H., et al. “Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and
gallstones during loss of weight.” New England Journal of Medicine Vol. 319, No. 24, 1988, pp. 1567-72.
[44] Marks, Jay W., George G. Bonorris, and Leslie J. Schoenfield. “Effects of ursodiol or ibuprofen on contraction
of gallbladder and bile among obese patients during weight loss.” Digestive Diseases and Sciences Vol. 41, No.
2, 1996, pp. 242-49.
[45] Festi, D., et al. “Gallbladder motility and gallstone formation in obese patients following very low calorie diets.
Use it (fat) to lose it (well).” International Journal of Obesity & Related Metabolic Disorders Vol. 22, No. 6,
1998.
[46] Behar, J., G. Mawe, and M. Carey. “Roles of cholesterol and bile salts in the pathogenesis of gallbladder
hypomotility and inflammation: Cholecystitis is not caused by cystic duct obstruction.” Neurogastroenterology
& Motility Vol. 25, No. 4, 2013, pp. 283-90.
[47] Tomida, Shinji, et al. “Long-term ursodeoxycholic acid therapy is associated with reduced risk of biliary pain
and acute cholecystitis in patients with gallbladder stones: A cohort analysis.” Hepatology Vol. 30, No. 1, 1999,
pp. 6-13.
[48] Warschkow, Rene, et al. “Concomitant cholecystectomy during laparoscopic Roux-en-Y gastric bypass in obese
patients is not justified: A meta-analysis.” Obesity Surgery Vol. 23, No. 3, 2013, pp. 397-407.
[49] Plecka Östlund, M., et al. “Population-based study of the need for cholecystectomy after obesity surgery.” British
Journal of Surgery Vol. 99, No. 6, 2012, pp. 864-69.
[50] Stender, Stefan, et al. “Sterol transporter adenosine triphosphate–binding cassette transporter G8, gallstones, and
Al-Mutlaq, et al. Int J Med Res Health Sci 2017, 6(12): 27-34
34
biliary cancer in 62,000 individuals from the general population.” Hepatology Vol. 53, No. 2, 2011, pp. 640-48.
[51] Krawczyk, Marcin, et al. “Phytosterol and cholesterol precursor levels indicate increased cholesterol excretion
and biosynthesis in gallstone disease.” Hepatology Vol. 55, No. 5, 2012, pp. 1507-17.
[52] Mofti, A.B., and M.S. Al-Saleh. “Bariatric surgery in Saudi Arabia.” Annals of Saudi Medicine Vol. 12, No. 5,
1992, pp. 440-45.
[53] Ashy, A.A., et al. “Laparoscopic adjustable silicone gastric banding in the treatment of super obesity in the
Jeddah area, Saudi Arabia. A preliminary report.” International Surgery Vol. 81, No. 3, 1996, pp. 289-91.
[54] Al-Akwaa, Ahmad M., and Ahmad Al-Salman. “Benefit of preoperative flexible endoscopy for patients
undergoing weight-reduction surgery in Saudi Arabia.” Saudi Journal of Gastroenterology: Official Journal of
the Saudi Gastroenterology Association Vol. 14, No. 1, 2008, p. 12.
[55] Aldaqal, Saleh M., et al. “Prevalence and desire for body are contouring surgery in post-bariatric patients in
Saudi Arabia.” North American Journal of Medical Sciences Vol. 4, No. 2, 2012, p. 94.
[56] Alqout, Ohud, and Frances Reynolds. “Experiences of obesity among Saudi Arabian women contemplating
bariatric surgery: An interpretative phenomenological analysis.” Journal of Health Psychology Vol. 19, No. 5,
2014, pp. 664-77.
[57] Alfadda, Assim A., et al. “The Saudi clinical practice guideline for the management of overweight and obesity
in adults.” Saudi Medical Journal Vol. 37, No. 10, 2016, p. 1151.