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Bir Köpekte Aşırı Doz Neostigmin Uygulanması Sonucu Şekillenen Tetraparezi Olgusu ve Sağaltım Sonuçları

The case of Tetraparesia Resulted from Hyperdose Neostigmine Application and Its Treatment Results

Journal Name:

  • Uludag University Journal of The Faculty of Veterinary Medicine

Publication Year:

  • 2014

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Eight-month-old, Rottweiler breed, a male dog was referred to our clinics with the cause of sudden onset paralysis. Due to recently encountered constipation problem, it was informed that B1-B6 vitamin, neostig-mine and paraffin liquid had been applied to increase the intestinal motility. Following the application, it was emphasized that limb weakness, in coordination, tetraparesis, dispnea, vomiting and soft defecation had seen, and dexamethasone and fluid therapy had been applied. After clinic and neurologic examinations, tetraparesis was diagnosed but application of atropine sulfate was not effective. Together with the B1-B6 vitamin, vitamin E –selenium and treatment protocol of diclofenac sodium, ranitidine and ampicillin-sulbactam was used. Gradually, patient started the clinical healing at 2nd day after medical management and the complete clinical return was achieved at 10th day.
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Abstract (Original Language): 
Sekiz aylık, Rotweiller ırkı, erkek bir köpek, ani şekillenen felç nedeniyle kliniklerimize sevk edildi. Kö-peğin son günlerde konstipasyon şikayeti çekmesi nedeniyle barsak peristaltiğini arttırmak için B1-B6 vitamini, neostigmin ve parafin likit uygulandığını belirtildi. Bu uygulama sonrası ekstremitelerinde güçsüzlük, inkoordi-nasyon, tetraparezi, solunum güçlüğü, kusma ve yumuşak kıvamlı defekasyon görüldüğü ve tedavi olarak dek-sametazon ve sıvı sağaltımı uygulandığı bildirildi. Klinik ve nörolojik muayeneler sonucu hastada tetraparezi tanımlandı ve atropin sülfat uygulamasına cevap alınamadı. B1 – B6 vitamini, E vitamini - selenyum ve sıvı uygulaması ile birlikte diklofenak sodyum, ranitidin ve ampisilin-sulbaktam tedavi protokolü olarak seçildi. Diklofenak sodyum uygulamasının 2. gününden itibaren kademeli olarak hastada düzelme ve 10 günde tamamen klinik geri dönüş gözlendi.
FULL TEXT (PDF): 
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REFERENCES

References: 

1. Aieloa, P.B., Borgesa, F.A., Romeiraa, K.M., Mirandab, M.C.R., Arrudac, L.B., Filhoc, P.N.L, Dragoc, B.C., Herculanoa, R.D., 2014. Evalua-tion of sodium diclofenac release using natural rubber latex as carrier. Materials Research, 17(2): in-press.
2. Cheng, C.R., Sessler, D.I., Apfel, C.C., 2005. Does neostigmine administration produce a clini-cally ımportant ıncrease in postoperative nausea and vomiting? Anesth Analg, 101(5), 1349-1355.
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5. Sharma R., 2008. Muscle paralysis with an acci-dental overdosage of neostigmine. Acta Anaest-hesiol Scand, 52(10), 1437.

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