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İmmun İlişkili Anemi ve İmmun İlişkili Trombositopenili (İT) Köpeklerde Prednisolon, Danazol ve Testosteron propionate’ın Ekinliğinin Karşılatırılması

Comparison of the Effects of Prednisolon, Danazol and Testosteron Propionat Therapy in Dogs with Immune Mediated Hemolytic Anemia and Thrombocytopenia

Journal Name:

  • Uludag University Journal of The Faculty of Veterinary Medicine

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The purpose of the study was to determine and compare the effectiveness of Prednisolon, Danazol and Testosteron propionate in the treatment of 45 dogs with IMHA and IMT. All dogs were selected from dogs diagnosed IMHA and IMT at the Uludag University Faculty of Veternary Medicine, Internal Medicine Clinic, 2003 and 2007 years comprised the animal population of the study. Clinical, biochemical and hematological examination were performed to all dogs during 3 weeks. Dogs in the present study were divided into 3 groups which consisted of 15 dogs. Group I received prednisolone at immunosuppressive doses. Group II received Danazol and also group III received testosterone propionate. The mainly manifesting disturbances in presentation were exercise intolerans, pale mucous membranes, icterus, hemoglobinuria, petechiae and ecchymosis, melena and epistaxis. Hemoglobin and hematocrit levels were significantly higher in group I and II compared with group III at the end of treatment (P=0.05). Thrombocyte counts were within normal reference limits in group I and II at the end of the therapy. In conclusion in this study, despite the normal response to conventional treatment, prednisolone therapy and danazol as synthetic androgen, it was deterimined that there were no anticipated effects by testosterone propionate for treatment of AIHA in dogs.
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Abstract (Original Language): 
Bu çalışma Prednisolon, Danazol ve Testosteron propionate’ın İmmun ilişkili anemi (İHA) ve immun ilişkili trombositopenili (İT) 45 köpeğin tedavisindeki etkinliğinin belirlenmesi ve karşılatırılması amacıyla yapıldı. Bütün köpekler 2003–2007 yılları arasında Uludağ Üniversitesi Veteriner Fakültesi İç Hastalıkları Kliniğiinde İHA ve İT taısı konan köpekler arasından seçildi. Bütün köpeklere ait klinik, hematolojik ve biyokimyasal muayeneler 3 hafta boyunca yapıldı. Çalışmada kullanılan köpekler her biri 15 köpekten oluşan 3 gruba ayrıldı; 1. Gruba immunsupresif dozajda prednisolone uygulandı. 2. Gruba Danazol ve 3. Gruba testoterone propionate uygulandı. Köpeklerde ilk muayene sonuçları arasında solgun mukoz membranlar, ikterus, hemoglobinüri, peteşi, ekimoz, melena ve epistaksis saptandı. Hemoglobin ve hematkrit düzeyleri tedavi sonunda 3. grup hayvanlara göre 1. ve 2. gruptaki hayvanlarda istatistiki olarak daha yüksek olarak saptandı (P=0.05) Trombosit sayısı tedavinin sonunda 1. ve 2. Gruptaki hayvanlarda normal sınırlar içindeydi. Sonuç olarak, prednisolone ve danazol uygulamaları tedavide etkili olurken, testosterone propionate tedavisde etkili olmadığı belirlenmiştir.
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REFERENCES

References: 

1. Ahn, J.S., Harrington, W.J., Mylvaganam, R.,
Ayub, J., Pall, L.M., 1985. Danazol therapy for
auto immune hemolytic anemia. Ann Intern Med.
102, 298-301.
2. Atikson, J.P., Schreiber, A.D., Frank, M.M.,
1973. Effects of corticosteroids and splenectomy
on the immune clearance and destruction of erythrocytes.
J Clin Invest. 52, 1509.
3. Balch, A., Mackin, A., 2007. Immunvermittelte
haemolytische Anaemie beim Hund: Pathophysiologie,
klinische Symptome und Diagnose. Tierarztl
Prax. 35, 302-308.
4. Bennett, D., Finnett, S.L., Nash A.S., Kirkham
D., 1981. Primary autoimmune haemolytic
anaemia in the dog. Vet Rec. 22, 150-153.
5. Bizzarro, A., Valentini, G., Di Martino, G., Daponte,
A., De Bellis, A., Iacono, G., 1987. Influence
of testosterone therapy on clinical and immunological
features of autoimmune diseases associated
with Klinefelter's syndrome. J Clin Endocr
Metab. 64, 32–36.
6. Bloom, J.C., Meunier, L.D., Thiem, P.A., Sellers,
T.S., 1989. Use of danazol for treatment of corticosteroid-
resistant immune-mediated thrombocytopenia
in a dog. J Am Vet Med Assoc. 194, 76-
78.
7. Burgess, K., Moore, A., Rand, W., Cotter, S.M.,
2000. Treatment of immune-mediated hemolytic
anemia in dogs with cyclophosphamide. J Vet Intern
Med. 14, 456-462.
8. Cicardi, M., Bergamaschini, L., Tucci A., Agostoni
A., Tornaghi G., Coggi G., Colombi R.,
Viale G., 1983. Morphologic evaluation of the
liver in hereditary angioedema patients on longterm
treatment with androgen derivatives. J Allergy
Clin Immun. 72, 294-298.
9. Dourakis, S.P., Tolis, G., 1998. Sex hormonal
preparations and the liver. Eur J Contracept Reprod
Health Care. 3, 7-16.
62
10. Flores, G., Cunningham-Rundles, C., Newland
A.C., Bussel J.B., 1993. Efficacy of intravenous
immunoglobulin in the treatment of autoimmune
hemolytic anemia: results in 73 patients. Am J
Hematol. 44, 237-242.
11. Fries, L.F., Brickman, C.M., Frank M.M., 1983.
Monocyte receptors for the Fc portion of IgG increase
in number in autoimmune hemolytic anemia
and other hemolytic states are decreased by
glucocorticoid therapy. J Immunol. 131, 1240-
1245.
12. Giger, U., 2000. Regenerative anemias caused by
blood loss or hemolysis. In: S.J. Ettinger and E.C.
Feldman (Eds): Textbook of Veterinary Internal
Medicine, W.B. Saunders, Philadelphia, pp.1896-
1901.
13. Hadley, S.P., Hoffmann W.E., Kuhlenschmidt
M.S., Sanecki R.K., Dorner J.L., 1990. Effect of
glucocorticoids on alkaline phosphatase, alanine
aminotransferase, and gammaglutamyltransferase
in cultured dog hepatocytes.
Enzyme. 43, 89-98.
14. Hickson, R.C., Ball, K.L., Falduto M.T., 1989.
Adverse effects of anabolic steroids. Med Toxicol
Adverse Drug Exp. 4, 254-271.
15. Holloway, S.A., Meyer, D.J., Mannella, C., 1990.
Prednisolone and danazol for treatment of immune-
mediated anemia, thrombocytopenia, and
ineffective erythroid regeneration in a dog. J Am
Vet Med Assoc. 197, 1045-1048.
16. Jackson, M.L, Kruth, S.A., 1985. Immunemediated
Hemolytic Anemia and Thrombocytopenia
in the Dog: A retrospective study of 55
cases diagnosed from 1979 through 1983 at the
Western College of Veterinary Medicine. Can
Vet J. 26, 245-250.
17. Kellerman, D.L., Bruyette, D.S., 1997. Intravenous
human immunoglobulin for the treatment of
immune-mediated hemolytic anemia in 13 dogs.
J Vet Intern Med. 11, 327–332.
18. Klag, A.R., Giger U., Shofer F.S., 1993. Idiopathic
immune-mediated hemolytic anemia in
dogs: 42 cases (1986-1990). J Am Vet Med Assoc.
202: 783-788.
19. Kopera, H., 1993. Side effects of anabolic steroids
and contraindications. Wien Med Wochenschr.
143, 399-400.
20. Lancia, A., Colella, F., Nicolella, U., Grandioso,
P., Di Virgilio, D., 1991. Hepatic damage after
danazol treatment. Ital J Gastroenterol. 23, 15-
16.
21. Mason, N., Duval, D., Shofer, F.S., Giger, U.,
2003. Cyclophosphamide exerts no beneficial effect
over prednisone alone in the initial treatment
of acute immune-mediated hemolytic anemia in
dogs: a randomized controlled clinical trial. J Vet
Intern Med. 17, 206–212.
22. Mccullough, S., 2003. Immune-mediated hemolytic
anemia: understanding the nemesis.
Vet Clin N Am-Small. 33, 1295-1315.
23. McManus, P.M., Craig, L.E., 2001. Correlation
between leukocytosis and necropsy findings in
dogs with immune-mediated hemolytic anemia:
34 cases (1994-1999). J Am Vet Med Assoc. 218,
1308-1313.
24. Miller, E., 1997. The use of danazol in the therapy
of immune-mediated disease of dogs. Semin
Vet Med Surg (Small Anim). 12, 167–169.
25. Miller, S.A., Hohenhaus A.E., Hale A.S., 2004.
Case-control study of blood type, breed, sex, and
bacteremia in dogs with immune-mediated hemolytic
anemia. J Am Vet Med Assoc. 224, 232-235.
26. Mills, J.N., 1997. Compensated immune mediated
haemolytic anaemia in a dog. Aust Vet J.
75: 177.
27. Naoko, K., Tesuya, T., Kunihiko T., 1997. Testosterone
suppresses anti-DNA antibody production
in peripheral blood mononuclear cells from
patients with systemic lupus erythematosus.
Arthritis Rheum. 40, 1703–1711.
28. Nelson, R.W., Couto C.G., 1998. Immune hemolytic
anemia In: Small Animal Internal Medicine
C.G. Couto Mosby, St. Louis, pp.1162-1164,
1998.
29. Olsen, N.J., Kovacks W.J., 1995. Case report:
testosterone treatment of SLE in a patient with
Klinefelter's syndrome. Am J Med Sci. 310, 158–
160.
30. Petz, L.D., Garratty G., 1980. Management of
autoimmune hemolytic anemias. In: Petz L.D.,
Garratty G. (Eds.), Acquired Immune Hemolytic
Anemias. Churchill Livingstone, New York, pp.
392-440.
31. Pugh, D.M., 1982. The hormones II: Anabolic
steroids In: Brander G.C., Pugh D.M., Water R.J.
(eds), Veterinary Applied Pharmacology and
Therapeutics. Bailliere Tindall, London. pp. 202-
206.
32. Reimer, M.E., Troy, G.C., Warnick, L.D., 1999.
Immune-mediated hemolytic anemia: 70 cases
(1988–1996). J Am Anım Hosp Assoc. 35, 384–
391.
33. Rosse, W., Bussel, J., Ortel, T., 1997. Challenges
in managing autoimmune disease. ASH Education
Book. 25, 92-101.
34. Solter, P.F., Hoffmann, W.E., Chambers M.D.,
Schaeffer D.J., Kuhlenschmidt M.S., 1994. Hepatic
total 3 alpha-hydroxy bile acids concentration
and enzyme activities in prednisone-treated
dogs. Am J Vet Res. 55, 1086-1092.
35. Switzer, J.W., Jain, N.C., 1981. Autoimmune
hemolytic anemia in dogs and cats.
Vet Clin N Am-Small 11, 405-4020.
63
36.Vaden, S.L., 1997. Cyclosporine and tacrolimus.
Semin Vet Med Surg (Small Anim). 12, 161–166.
37. Van Vollenhoven, R.F., Morabito, L.M., Engleman,
E.G., Mcguire, J.L., 1998. Treatment of
SLE with DHEA: 50 patients treated up to 12
months. J Rheumatol. 25, 285–289.
38. Weinkle, T.K., Center, S.A., Randolph, J.F.,
Warner, K.L., Barr, S.C., Erb, H.N., 2005. Evaluation
of prognostic factors, survival rates, and
treatment protocols for immune-mediated hemolytic
anemia in dogs: 151 cases (1993-2002). J
Am Vet Med Assoc. 226, 1869-1880.
39. Yaginuma, T., Okamura, T., Takeuchi, T., Nishii,
O., Fujimori, R., 1989. Preventive effect of traditional
herbal medicine, shosaiko-to, on danazolinduced
hepatic damage. Int J Gynaecol Obstet.
29, 337-41.
40. Yeo, S.W., Park, S.N., Chang, K.H., Chae S.,
Park Y.S., 2000. Effects of Testosterone in the
Treatment of Immune-mediated Hearing
Loss. Korean J Otolaryngol. 43, 1066-1072.
41. Zofkova, I., Kancheva, R.L., Hampl, R., 1995. A
decreasing CD4+/CD8+ ratio after one month of
treatment with stanozol in postmenapausal women.
Steroids. 60, 430–433

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