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Otistik Bozukluğu Olan Çocuk ve Ergenlerde Kolesterol Düzeyleri

Cholesterol Levels in Children and Adolescents with Autistic Disorder

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Autism, a neurodevelopmental disorder, Is defined by core abnormalities In reciprocal social Interaction and communication, and by the presence of restrictive or stereotyped interests and behaviors. Its etiology is almost unclear however a number of factors is being investigated including genetic, infectious, metabolic and environmental causes. Recent findings suggest the role of abnormal lipid metabolism in autism. The aim of this study was to investigate the incidence of cholesterol deficiency in a group of subjects with autistic dis-order (AD). Study group included 88 children and adolescents with autistic disorder according to DSM-IV criteria. Children with any diagnosed genetic, metabolic, or neurological disorders were excluded from the study. The mean cholesterol level was 150.5 ± 28.7 (81.0 - 230.0) mg / dl. Sixteen subjects (18.2 %) had a cholesterol level lower than 100 mg/dl, which is below the 5th centile. Our findings confirmed the high prevalence of abnormally low cholesterol levels in autistic disorder and support clinical significance regarding the possible role of cholesterol deficit in the etiology. Further studies are needed to investigate the relation between cholesterol metabolism and autism.
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Abstract (Original Language): 
Otizm sosyal İlişki ve İletişim alanlarında belirgin güçlükler, ylneleylcl-sınırlı-olağan dışı davranış ve ilgilerin olduğu nörogelişimsel bir bozukluktur. Otizmin nedeni halen net olarak bilinmemektedir fakat genetik, immünolojik, metabolik ve çevresel faktörlerin etkileşimiyle oluşan multifaktoriyel bir bozukluk olduğu düşünülmektedir. Otizmin etyolojisinde lipid metabolizmasında bozulmanın bulunduğuna dair kanıtlar giderek artmaktadır. Bu çalışmada otistik bozukluğu olan çocuk ve ergenlerin kolesterol düzeylerinin incelenmesi amaçlanmıştır. Çalışmaya DSM - IV ölçütlerine göre otistik bozukluk tanısı alan 88 çocuk ve ergen alınmıştır. Bilinen her hangi bir genetik, metabolik ve/veya nörolojik hastalığı olan olgular çalışma dışı bırakılmıştır. Ortalama kolesterol düzeyi 150.5 ± 28.7 (81.0 - 230.0) mg / dl olarak bulunmuştur. On altı olgunun (% 18.2) kolesterol düzeyinin iki yaşından büyük çocuklar için 5. persantil değeri olan 100 mg/dl'den düşük olduğu görülmüştür. Bu bulgular kolesterol metabolizmasında bozulmanın otistik bozukluk etyolojisinde rol alabileceğini desteklemektedir. Otizm ile kolesterol metabolizması arasında ilişkiyi inceleyen daha ileri çalışmalara gereksinin bulunmaktadır.
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  • 4
226-228
  • Turkish

REFERENCES

References: 

1. Boston PF, Dursun SM, Reveley MA. Cholesterol and mental disorder. Br J Psychiatry 1996; 169: 682 - 689.
2. Sevincok L, Buyukozturk A, Dereboy F. Serum lipid concentrations in patients with comorbid generalized anxiety disorder and major depressive disorder. Can J Psychiatry. 2001;46(1): 68 - 71.
3. Shioiri T, Fujii K, Someya T, Takahashi S. Serum cholesterol levels and panic symptoms in patients with panic disorder: a preliminary study. J Affect Disord. 2000; 58(2): 167 - 170.
4. Kagan BL, Leskin G, Haas B, Wilkins J, Foy D. Elevated lipid levels in Vietnam veterans with chronic posttraumatic stress disorder. Biol Psychiatry 1999; 45(3): 374 - 377.
5. Peter H, Hand I, Hohagen F, Koenig A, Mindermann O, Oeder F, Wittich M. Serum cholesterol level comparison: control subjects, anxiety disorder patients, and obsessive-compulsive disorder patients. Can J Psychiatry
2002; 47(6): 557 - 561.
6. Atmaca M, Kuloglu M, Tezcan E, Ustundag B. Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatr Scand 2003; 108(3): 208 - 214.
7. Virkkunen M. Serum cholesterol in antisocial personality. Neuropsychobiology 1979; 5(1): 27 - 30.
8. Atmaca M, Kuloglu M, Tezcan E, Gecici O, Ustundag B. Serum cholesterol and leptin levels in patients with borderline personality disorder. Neuropsychobiology. 2002; 45(4): 167 - 171.
9. Troisi A. Low cholesterol is a risk factor Low cholesterol is a risk factor

for attentlonal impulsivity in patients with mood symptoms. Psychiatry Res 2011; 188(1): 83 - 87.
10. Buydens-Branchey L, Branchey M, Hudson J, Fergeson P. Low HDL cholesterol, aggression and altered central serotonergic activity. Psychiatry Res 2000; 93(2): 93 - 102.
11. Plana T, Gracia R, Méndez I, Pintor L, Lazaro L, Castro-Fornieles J. Total serum cholesterol levels and suicide attempts in child and adolescent psychiatric inpatients. Eur Child Adolesc Psychiatry 2010; 19(7): 615 - 619.
12. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). Washington DC, American Psychiatric Association, 2000.
13. Steyaert JG, De la Marche W. What's new in autism? Eur J Pediatr 2008; 167(10): 1091 - 1101.
14. Muhle R, Trentacoste SV, Rapin I. The genetics of autism. Pediatrics 2004; 113(5): e472 - 486.
15. Tamiji J, Crawford DA. The neurobiology of lipid metabolism in autism spectrum disorders. Neurosignals 2010; 18(2): 98 - 112.
16. Tierney E, Bukelis I, Thompson RE, Ahmed K, Aneja A, Kratz L, Kelley RI. Abnormalities of cholesterol metabolism in autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet 2006; 141B (6): 666 - 668.
17. Kim EK, Neggers YH, Shin CS, Kim E, Kim EM. Alterations in lipid profile of autistic boys: a case control study. Nutr Res 2010; 30(4): 255-260.
18. Breitling R. Greased hedgehogs: new links between hedgehog signaling and cholesterol metabolism. Bioessays 2007; 29(11): 1085 - 1094.
19. Saher G, Simons M. Cholesterol and myelin biogenesis. Subcell Biochem 2010; 51: 489 - 508.
20. Gimpl G, Burger K, Politowska E, Ciarkowski J, Fahrenholz F. Oxytocin receptors and cholesterol: interaction and regulation. Exp Physiol 2000; 85 Spec No: 41S - 49S.

21. Allen JA, Halverson-Tamboli RA, Rasenick MM. Lipid raft microdomains and neurotransmitter signalling. Nat Rev Neurosci. 2007; 8(2): 128 - 140.
22. Aneja A, Tierney E. Autism: the role of cholesterol in treatment. Int Rev Psychiatry 2008; 20(2): 165-70.
23. Asellus P, Nordström P, Jokinen J. Cholesterol and CSF 5-HIAA in attempted suicide. J Affect Disord 2010; 125(1-3): 388 - 392.
24. Kaplan JR, Shively CA, Fontenot MB, Morgan TM, Howell SM, Manuck SB, Muldoon MF, Mann JJ. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosom Med. 1994; 56(6): 479 - 484.
25. Vevera J, Fisar Z, Kvasnicka T, Zdenek H, Stärkovä L, Ceska R, Papezovä H. Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission. Psychiatry Res 2005; 133(2-3): 197 - 203.
26. Hawthon K, Cowen P, Owens D, Bond A, Elliott M. Low serum cholesterol and suicide. Br J Psychiatry 1993; 162: 818 - 825.
27. Lam KS, Aman MG, Arnold LE. Neurochemical correlates of autistic disorder: a review of the literature. Res Dev Disabil 2006; 27(3): 254 - 289.
28. Bukelis I, Porter FD, Zimmerman AW, Tierney E. Smith-Lemli-Opitz syndrome and autism spectrum disorder. Am J Psychiatry 2007; 164(11): 1655 - 1661.
29. Tierney E, Nwokoro NA, Porter FD, Freund LS, Ghuman JK, Kelley RI. Behavior phenotype in the RSH/Smith-Lemli-Opitz syndrome. Am J Med Genet 2001; 98(2): 191-200.
30. Sikora DM, Pettit-Kekel K, Penfield J, Merkens LS, Steiner RD. The near universal presence of autism spectrum disorders in children with Smith-Lemli-Opitz syndrome. Am J Med Genet A 2006; 140(14): 1511 - 1518.

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