You are here

Home » Content

Sıçanlarda Aralıklı Hipobarik Maruziyet ve Normobarik Antrenman Sürecinin Bazı Kan Parametreleri ve Doku Eser Element Düzeyleri Üzerine Etkisi

Effects of intermittent hypobaric exposure and normobaric training on some blood parameters and tissue trace elements of rats

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objectives: Living at moderate altitudes and training at lower altitudes or at sea level is a well known training model for preparation to competitions. In our study we investigated the hemopietic parameters; Hb, Hct and plasma ferritin and the tissue levels of trace metals (Fe, Cu and Zn) which are closely related to those homopoietic parameters in liver and spleen of rats which are intermittently exposed to atmospheric pressure of 3000 m and swim trained at sea level. Methods: 48 Wistar albino male rats randomly and equally divided into 4 groups: hypobaric exercise, hypobaric sedentary, normobaric exercise and normobaric sedentary group. Exercising rats performed swimming in a water tank for 30 minutes a day, 4 days a week for 9 weeks, hypobaric groups experienced their hypobaric exposures in a hypobaric chamber which has the atmospheric pressure of an altitude of 3000 m for 2 hours a day, 4 days a week for 9 weeks. In the tissue samples of the rats Fe, Cu and Zn assays were achieved by atomic absorption spectrofotometer and serum ferritin was determined by Active Ferritin Coated-Tube Immunoradiometric Assay (IRMA). Results: Cu and Fe levels in tissues of liver and spleen were significantly lower in hypobaric groups compared to normobaric groups. Whereas the Hb level of hypobaric exercise group was significantly higher than normobaric exercise group, Hct level of this group was significantly higher than both normobaric groups. There were no significant diffrence in tissue levels of Zn and serum ferritin levels between the groups. Conclusion: Results of our study suggests that Fe and Cu levels in a requirement and consumption context should be considered more carefully in a period of training which has intermittent hypobaric exposures.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-sicanlarda-aralikli-hipobarik-maruziyet-normobarik-antrenman-surecinin-bazi-kan-parametreleri-doku-eser-element-duzeyleri-uzerine-etkisi.pdf
  • 1
15-21
  • Turkish

REFERENCES

References: 

1. Levine BD, Stray-Gundersen J. "Living high-training
low": effect of moderate-altitude acclimatization with
low-altitude training on performance. J Appl Physiol
1997; 83: 102-112.
2. Roberts AD, Clark SA, Townsend NE, et al. Changes
in performance, maximal oxygen uptake and maximal
accumulated oxygen deficit after 5, 10 and 15
days of live high: train low altitude exposure. Eur J
Appl Physiol 2003; 88: 390-395.
3. Stray-Gundersen J, Chapman RF, Levine BD. "Living
hightraining low" altitude training improves sea level
performance in male and female elite runners. J Appl
Physiol 2001; 91: 1113-1120.
20
M. Altan ve ark.
21
4. Robergs RA, Roberts SO, eds. Exercise in extreme environments,
exercise physiology, exercise performance
and clinical applications. St. Louis: Mosby; 1997:
640-653.
5. Speich M, Pineau A, Ballereau F. Minerals, trace elements
and related biological variables in athletes and
during physical activitiy. Clin Chim Acta 2001; 312:
1-11.
6. Andrews NC. Disorders of iron metabolism. N Engl J
Med 1999; 341: 1986-1995.
7. Maughan RJ. Role of micronutrients in sport and
physical activity. Br Med Bull 1999; 55: 683–690.
8. Chan S, Gerson B, Subramaniam S. The role of copper,
molybdenum, selenium, and zinc in nutrition
and health. Clin Lab Med 1998; 18: 673-685.
9. Miles LEM, Lipschitz DA, Bieber CP, Cook JD. Measurement
of ferritin by a 2- site immunoradiometric assay.
Analyt Biochem 1974; 61: 209-224.
10. Knaupp W, Khilnani S, Sherwood J, et al. Erythropoietin
response to acute normobaric hypoxia in humans.
J Appl Physiol 1992; 73: 837-840.
11. Schmidit W. Effects of intermittent exposure to high
altitude on blood volume and erythropoietic activity.
High Alt Med Biol 2002; 3: 167-176.
12. Lukaski HC. Magnesium, zinc, and chromium nutriture
and physical activity. Int J Clin Nutr 2000; 72:
585S-593S.
13. Maughan RJ. Role of micronutrients in sport and
physical activity. Br Med Bull 1999; 55: 683-690.
14. Rawal SB, Singh MV, Tyagi AK, et al. Effect of time exposure
to high altitude on zinc and copper concentrations
in human plasma Aviat Space Environ Med
1999; 70: 1161-1165.
15. Vats P, Singh SN, Kumria MM, et al. Effect of hypoxia
on the circulating levels of essential mineral elements
in rats. J Environ Biol, 2001; 22: 277-282.
16. Navas FJ, Cordova A. Iron distribution in different tissues
in rats following exercise. Biol Trace Elem Res
2000; 73: 259-268.
17. Kaptano¤lu B, Turgut G, Genç O, ve ark. Effects of
acute exercise on the levels of iron, magnesium, and
uric acid in liver and spleen tissues. Biol Trace Elem
Res 2003; 91: 173-178.
18. Ruckman KS, Sherman AR. Effects of exercise on iron
and copper metabolism in rats. J Nutr 1981; 111:
1593-1601.
19. Bordin D, Sartorelli L, Bonanni G, et al. High intensity
physical exercise induced effects on plasma levels of
copper and zinc. Biol Trace Elem Res 1993; 36: 129-
134.
20. Metin G, Atukeren P, Alturfan AA, ve ark. Lipid peroxidation,
erythrocyte superoxide-dismutase activity
and trace metals in young male footballers.
Yonsei Med J 2003; 44: 979-986.
21. Lukaski HC. Micronutrients (magnesium, zinc, and
copper): are mineral supplements needed for athletes?
Int J Sport Nutr 1995; 5: S74-83.
22. Kobayashi A. Trace element and hormonal responses
during a flight aptitude test. Aviat Space Environ Med
1996; 67: 333-337.
23. Cordova A, Navas FJ. Effect of training on zinc metabolism:
changes in serum and sweat zinc concentrations
in sportsmen. Ann Nutr Metab 1998; 42:274-
282.
24. Shephard RJ, Shek PN. Immunological hazards from
nutritional imbalance in athletes. Exercise Immunol
Rev 1998; 4: 22-48.
25. Karakoç Y, Yurdakofl E, Gülyaflar T, ve ark. Experimental
stress-induced changes in trace element levels
of various tissues in rats. J Trace Elem Exp Med 2003;
16: 55-60.
26. Karakoç Y, Turhan S, Y›ld›r›m EA, ve ark. Neuropeptide
Y alters stress-induced changes in trace element
concentrations of brain in chronically immobilized
rats. J Trace Elem Exp Med 2003; 17: 283-290.
27. Rodriguez TI, Pinilla GE, Maynar MM, et al. A. Evaluation
of the influence of physical activity on the plasma
concentrations of several trace metals. Eur J Appl
Physiol 1996; 73: 299-303.
28. Nuviala RJ, Lapieza MG, Bernal E. Magnesium, zinc,
and copper status in women involved in different
sports. Int J Sport Nutr 1999; 9: 295-309.

Thank you for copying data from http://www.arastirmax.com