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FORMULATION AND IN-VITRO CHARACTERIZATION OF TRIMETAZIDINE DIHYDROCHLORIDE FLOATING BILAYER M.R. TABLETS

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2011

Key Words:

Author Name
Abstract (2. Language): 
Bilayer tablets contain immediate and sustained release layer. Immediate release layer delivers the initial dose, it contains superdisintegrants which increase drug release rate whereas sustained release layer float due to gas generating agent and releases drug at sustained manner for prolonged period. In my present work, aim is to formulate various batches of bilayer modified release floating tablet and evaluate it in-vitro. We also evaluated the various formulations for the effect of crosspovidone, sodium bicarbonate, compression force and stirring rate. At the end we came to conclusion that by altering these factors, it will affect the drug release positively or negatively.
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  • 1
28-34
  • English

REFERENCES

References: 

1. M. E. Aulton. The science of dosage
form design, II ed. Modified release
dosage form, 2002, pp.289-305.
2. A. Ahuja, R. Khar, J. Ali. Mucoadhesive
drug delivery systems, Drug Dev. Ind.
Pharm 23: 489-492 (1997).
Biswajit Biswal et al., ARPB, 2011; Vol 1(1) ISSN 2250 - 0774
(Research paper)
www.arpb.info Page 34
3. M. H. Amartal, J. M. Lobo, D. C.
Ferreira. Effect of hydroxyl propyl
methyl cellulose and hydrogenated
castor oil on naproxen release tablets,
AAPS Pharm Sci Tech.2 (2): 1-8 (2001).
4. J. Ali, S. Arora, A. Ahuja, A. Babbar, R.
Sharma, R. Khar, S. Baboota.
Formulation and development of
hydrodynamically balanced system for
metformin: in vitro and in vivo
evaluation, Eur. J. Pharm. Biopharm. 67:
196-201(2007).
5. S. Arora, J. Ali, A. Ahuja, R. Khar, S.
Baboota. Floating drug delivery system:
A review, AAPS Pharm Sci. Tech. 6:
E372- E390 (2005).
6. A. Bansal, G. Chawla, P. Gupta, V.
Koradia. Gastroretention: a means to
address regional variability in intestinal
drug absorption, Pharmaceutical
technology 07: 50-68(2003).
7. S. C. Basak, J. Reddy, K.P. Lucas Mani.
Formulation and release behaviour of
sustained release ambroxol Hcl HPMC
matrix tablet, Indian J. Pharm. Sci (09-
10), 594-598 (2006).
8. S. Baumgartner, J. Kristl, F. Vrecer, P.
Vodopiec, B. Zorko. Optimization of
floating matrix tablets and evaluation of
their gastric residence time, Int. J.
Pharm. 195: 125-135 (2000).
9. T. Bussemera, N. Peppasb, R.
Bodmeiera. Evaluation of the swelling,
hydration and rupturing pulsatile drug
delivery system, Eur. J. Pharm.
Biopharm. 56: 261-270 (2006).
10. P. Chaudhari, S. Chaudhari, S. Kolhe, K.
Dave, D. More. Formulation and
evaluation of fast dissolving tablets of
famotidine, Indian drugs, 42 (10): 641-
648 (2005).

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