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EFFECT OF OCIMUM BASILICUM ON CISPLATIN MODELS OF ACUTE RENAL FAILURE

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Abstract (2. Language): 
The hydroalcoholic extract of the entire plant of Ocimum basilicum was studied for its nephroprotective activity in cisplatin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 100, 300 and 500 mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. The findings suggested that the ethanol extract of Ocimum basilicum possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin.

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