You are here

Home » Content

EFFECT OF ALOE VERA (L). BURM. F POLYSACCHARIDE ON VARIOUS IMMUNE PARAMETERS

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
In present study, we studied the effect of Aloe vera polysaccharide on various immune parameters. Aloe Vera polysaccharide showed significant (p<0.001) stimulation of phagocytosis (82.9924+2.4488) at a concentration 100 μM. Aloe vera polysaccharide at 200 μM had no significant cytotoxic effect towards human lymphocytes. The polysaccharide was examined for its antioxidant potential. Aloe polysaccharide possesses observable antioxidant activity as its EC50 value was found to be 3.5μgm/ml, which is significant when compared to standard solution of ascorbic acid whose EC50 value is 2.86μm/ml. Aloe vera inner gel was evaluated for its antimicrobial activity against Escherichia coli. In the present study, the inner gel of Aloe vera was tested for its antibacterial property against Escherichia coli (strain no: NCIM 2118) using pour plate method. The fresh gel at 50%-100% showed significant inhibition of growth of the colonies. These results indicate that Aloe Vera polysaccharide possess significant immunomodulatory activity and other therapeutic uses such as an antioxidant
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastrmx_160852_2_pp_300-304.pdf
  • 3
300-304
  • English

REFERENCES

References: 

1. S. A. Im, S. T. Oh, S. Song, M. R. Kim, D. S. Kim, S. S.
Woo, T. H. Jo, Y. I. Park, C. K. Lee. Identification of
optimal molecular size of modified Aloe
polysaccharides with maximum
immunomodulatory. International
Immunopharmacology 5(2): 271-279 (2005).
2. J. G. Lin, G. W. Chen, T. M. Li, S. T. Chouh , T. W. Tan
and J.G. Chung . Aloe-emodin induces apoptosis in
T24 bladder cancer cells through the p53 apoptic
pathway. Journal of Urology 175(1): 343-
347(2006).
3. N. Pugh, S. A. Ross , M A. Elsohly and D. S. Pasco.
Characterization of Aloeride, a new High-molecular
weight polsaccharide from Aloe vera with potent
immunostimulating activity. Journal of Agricultural
and Food Chemistry 49(9): 1030-34 (2001).
4. I. L. Finar . Organic Chemistry: Stereochemistry and
the chemistry of Natural Products; North London:
Pearson Education, 5th edition, 1975 336.
5. S. R. Kulkarni and V. S. Karande. Study of the
Immunostimulant activity of Naphthoquinone
extract of leaves of LawSonia Alba Linn. Indian
Drugs 35(7): 427-433(1998).
6. S. Biswas, V. K. Singh, A. Rastogi, R. Sharan, W. Haq
and K.B. Mathur. Stimulation of IL-2 production and
CD2R expression by splenopentin analogs. Int. J.
Immunopharmacol. 19, 341-345 (1997).
7. L. L. Mensor , F.S. Menezes, G.G. Leitao, A.S.Reis, T.C.
dos Santos, , C.S. Coube and S.G. Leitao. Screening of
Sumita et al., ARPB, 2012; Vol 2 (III) ISSN 2250-0774
(RESEARCH ARTICLE)
304 | P a g e w w w . a r p b . i n f o
Brazilian plant extracts for Antioxidant Activity by
the use of DPPH free Radical method. Phytotherapy
Research 15: 127-130 (2001).
8. B. S. Shylesh, N. S. Ajikumaran and A. Subramoniam.
Induction of cell specific apoptosis and protection
from Dalton lymphoma challenge in mice by an
active fraction from Emilia sonchifolia. Indian
Journal of Pharmacology 37(4): 232-237 (2005).
9. E. P. Reeves, H. Lu, H. L. Jacobs, C. G. M. Massina, S.
Bolsover, G. Gabella. Killing activity of neutrophils is
mediated through activation of proteases by K+ flux.
Nature 416: 291-297 (2002)
10. O. O. Agarry, M. T. Olaleye, and C. O. Bello-Michael,
Comparative antimicrobial activities of Aloe vera
gel and leaf. African Journal of Biotechnology;
4(12): 1413-1414 (2005).

Thank you for copying data from http://www.arastirmax.com