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ROLE OF SEROTONIN IN RELAPSE TO NICOTINE ADDICTION: AN OVERVIEW

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Drug addiction is regarded as the disease of the brain reward system which is considered a complex disease of the CNS. Nicotine addiction involved not only counter adaptive changes of endogenous serotonin and its receptor system, but also adaptive changes of many other neuronal transmitter systems. This study reviewed the neurobiology of nicotine addiction, the neural mechanisms of addictive drugs that can be localized to a variety of brain regions and neuronal circuitry underlying the progressive increase in nicotine relapse. Relapse can be modeled in laboratory animals by using conditioned place preference which widely is used from decades. This study also examined the role of selective serotonin reuptake inhibitors in relapse to nicotine dependence using the different inhibitors e.g. sertinazole, fluoxetine and other inhibitors significantly alter the nicotine phenomenon.
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  • 3
157-166
  • English

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(Review Article)
www.arpb.info Page 166
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