Journal Name:
- Advance Research in Pharmaceuticals and Biologicals
Key Words:
| Author Name | University of Author |
|---|---|
Abstract (2. Language):
Fenofibrate (FFB) is an effective lipid regulating agent. Chemically it is 2-[4-(4-chloro benzoyl]-2 methyl propanoic acid,
1-methyl ethyl ester. It belongs to BCS class II and require enhancement in solubility and dissolution rate for increasing
its oral bioavailability. In the present work, β- Cyclodextrin (β-CD) and Hydroxy Propyl β- Cyclodextrin (HP β-CD)
complexes of FFB were prepared and evaluated for solubility and dissolution rate .The aqueous solubility was increased
linearly as a function of the concentration of cyclodextrins. Physical characterization of solid inclusion complexes of FFB
was studied by DSC and IR. An increase of 21 and 30 fold in the dissolution rate of FFB was observed with FFB- β-CD
(1:3) - F6 and FFB- HP β-CD (1:3) - F12 prepared by kneading method respectively. The increase in the dissolution rate
of the drug may be due to increase of wettability, the hydrophilic nature of carriers and also due to possibility of
reduction in drug crystallinity.
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FULL TEXT (PDF):
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420-425