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DİSTRAKSİYON OSTEOGENEZİNİN BİYOLOJİK TEMELİ

BIOLOGIC BASE OF DISTRACTION OSTEOGENESIS

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Abstract (2. Language): 
Distraction osteogenesis has become a mainstay in bone tissue engineering and has significantly improved our armamentarium for reconstructive cran-iomaxillofacial procedures. Recent studies have implicated a growing number of cytokines that are inti¬mately involved in the regulation of bone synthesis and turnover. It is believed that understanding the bio-molecular mechanisms that mediate membranous dis¬traction osteogenesis may guide the development of targeted strategies designed to improve distraction osteogenesis and accelerate bone healing. This article presents the hypotheses and current research that have furthered knowledge of the molecular mechanisms that govern distraction osteogenesis.
Abstract (Original Language): 
Distraksiyon osteogenezisi kemik doku mühendisliğinde başlıca dayanak haline gelmiş ve rekonstrüktif kraniomaksillofasiyal prosedürler için tedavi şeklini anlamlı bir şekilde geliştirmiştir Son zamanlardaki çalışmalara kemik sentezi ve dönüşümünün regülasyonunda rol alan sitokinler dahil edilmiştir. Distraksiyon osteogenezisinin biomoleküler mekanizmasının anlaşılması, distraksiyon osteo-genezisi ve hızlandırılmış kemik iyileşmesinde tedavi stratejilerinin gelişmesi açısından yol gösterecektir. Bu makale hipotezler ve distraksiyon osteogenezisinin moleküler mekanizmaları hakkında hali hazırdaki çalışmaları içermektedir.
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