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ORAL KONTRASEPTİF AJANLARIN KLİNİK PERİODONTAL PARAMETRELER ÜZERİNE ETKİLERİ

THE EFFECTS OF ORAL CONTRACEPTIVES AGENTS ON CLINICAL PERIODONTAL PARAMETERS

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Abstract (2. Language): 
Aim: Oral contraceptive agents are one of the most widely ultized class of drugs in the world. Clinical studies have demonstrated that women using oral contraceptive drugs have a higher incidence of gingival inflammation in comparison to women who don't use these agents. And also, combination use of oral contraceptives has been associated with changes in periodontal attachment levels. The purpose of this study is to investigate the effects of oral contraceptives to the gingival inflammation in humans. Method: 10 women using hormonal contra¬ceptives for less than 1 year, 12 for 1-2 years, for more than 2 years and matched control group of 30 non-users were selected for the study. They were clinically examined for plaque levels (plaque index), gingival condition (gingival index) and loss of periodontal attachment. Results: Contraceptive users and non-users had similar oral hygiene levels (p>0,05); yet the con¬traceptive users had a significantly higher level of gin-gival inflammation and loss of periodontal attachment, compared to the non-users (p<0.001). Usage of oral contraceptives for more than 2 years caused a signifi¬cantly higher loss of periodontal attachment compared to that of controls and the other users (for less than 2 years) (p<0,001). Conclusions: Usage of contraceptive prepara¬tions containing oestrogen and progesterone resulted in hormonal changes similar to those seen in pregnan¬cy, associated with increased prevalence of gingivitis. There was significantly higher loss of periodontal attachment with prolonged usage of hormonal contra¬ceptives.
Abstract (Original Language): 
Amaç: Oral kontraseptif ajanlar dünyada çok yaygın olarak kullanılan ilaçlar arasındadır. Klinik çalışmalarda oral kontraseptif kullanan kadınlarda kullanmayanlara göre daha çok dişeti iltihabı görülmektedir. Bununla birlikte, kombine olarak bu ilaçların kul¬lanımı periodontal ataçman kaybına sebep olabilmek¬tedir. Bu çalışmada amacımız, insanlarda oral kontraseptif kullanımının periodontal parametreler üzerine etkilerini araştırmaktı. Metot: Oral kontraseptif kullanan 30 kadın kullanma sürelerine göre üç alt gruba ayrılarak (1 seneden az kullanım 10 kişi,1-2 sene arası kullanım 12 kişi, 2 seneden fazla kullanım 8 kişi) ve kontrol amacıyla herhangi bir oral kontraseptif ve benzeri ajan kullan¬mayan 30 kadın çalışmaya dahil edildi. Bireyler klinik olarak plak indeksi-Pİ, gingival indeks-Gİ ve ataçman kaybı (Klinik ataçman seviyesi-KAS; mm olarak) bakımından değerlendirildi. Bulgular: Oral kontraseptif kullanan ve kul¬lanmayanların plak indeksi skorları arasında fark olmamasına rağmen (p>0,05), gingival indeks değer¬leri arası farklılığın istatistiksel olarak önemli olduğu bulunmuştur (p<0,001). 2 seneden fazla oral kon-traseptif kullananlarda daha fazla ataçman kaybı olduğu saptanmıştır (p<0,001). Sonuç: Östrojen ve progesteron içeren oral kontraseptif ajanların kullanımı hamilelikte olduğu gibi benzer hormonal değişikliklerle sonuçlanarak, gingivitis prevelansının artmasıyla ilişkilidir. Uzun süreli hormonal kontraseptiflerin kullanımı yüksek periodontal ataçman kaybına sebep olur.

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