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REKÜRRENT AFTÖZ STOMATİTİSLİ HASTALARDA TÜKÜRÜK ANTİOKSİDAN SEVİYELERİ

SALIVARY ANTIOXIDANT LEVELS IN PATIENTS WITH RECURRENT APHTHOUS STOMATITIS

Journal Name:

  • Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Despite plenty of research, the exact etiology for Recurrent Aphthous Stomatitis (RAS), one of the most common oral ulcerative diseases, still remains unclear. Predisposing factors such as trauma, microbial factors, food, drug reactions, immune disorders, hormonal imbalance and smoking, all of which trigger free radical formation and upset the oxidant/antioxidant balance of an organism, as well as familial tendency, are believed to be involved in the etiology of RAS. With its contents of antioxidant molecules and enzymes, saliva is the first step of the defensive mechanism against free radicals. The aim of the present study is to determine the salivary Total Antioxidant Capacity (TAC), Uric Acid (UA) levels, and Glutathione Peroxidase (GPx) activity in patients with RAS and to investigate the possible relations of these parameters to RAS. Unstimulated saliva samples were obtained from a total of 75 individuals: 50 patients with RAS and 25 healthy individuals who formed the control group. The TAC, UA levels and GPx activity were determined for the samples. No significant difference was found between the patient and control groups with regard to their salivary TAC and UA levels (p>0.05). GPx activity was lower in the saliva of the patients with RAS when compared to the control group (p<0.05).
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Abstract (Original Language): 
Dünyada en sık görülen oral ülseratif hastalıklardan birisi olan Rekürrent Aftöz Stomatitisin (RAS) yapılan birçok araştırmaya rağmen kesin etiyolojisi bulunamamıştır. Serbest radikal formasyonunu tetikleye-rek organizmanın oksidan/antioksidan dengesini bozan travma, mikrobiyal faktörler, yiyecekler, ilaç reaksiyonları, immun bozukluklar, hormonal dengesizlik, sigara gibi predispozan faktörlerin ve ailesel eğilimin RAS'ın etiyolojisinde de rol aldığı düşünülmektedir. Tükürük, içerdiği antioksidan moleküller ve enzimler ile serbest radikallere karşı ilk savunma basamağıdır. Bu çalışmanın amacı RAS hastalarında tükürük total antioksidan kapasitesi (TAK), ürik asit (ÜA) seviyesi ve glutatyon peroksidaz (GPx) aktivitesinin tespit edilmesi ve bu parametrelerin RAS ile herhangi bir ilişkileri olup olmadığının araştırılmasıdır. 50 RA S hastası ve 25 kontrol grubu olmak üzere toplam 75 bireyden uyarılmamış tükürük örnekleri toplandı. Numunelerde TAK, ÜA seviyesi ve GPx aktivitesi tayin edildi. Hasta ve kontrol grubunun tükürük TAK ve ÜA seviyeleri arasında anlamlı bir fark bulunamadı (p>0.05). RAS hastalarının tükürüklerinde GPx aktivitesi kontrol grubundan daha düşük (p<0.05) bulundu.
FULL TEXT (PDF): 
PDF icon arastirmax-rekurrent-aftoz-stomatitisli-hastalarda-tukuruk-antioksidan-seviyeleri.pdf
  • 3
99-104
  • Turkish

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Cilt: 18, Sayı: 3, Yıl: 2008, Sayfa: 99-104
ÇAĞLAYAN, YILMAZ
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