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PERIODONTAL DOKU YIKIMINDA REAKTIF OKSİJEN TÜRLERİNİN ROLÜ

THE ROLE OF REACTIVE OXYGEN SPECIES IN PERIODONTAL TISSUE DESTRUCTION

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Abstract (2. Language): 
In periodontal diseases tissue destruction occurs in two ways; directly and indirectly. The bacteria colonized in gingival crevicular and periodontal pocket and enzymes derived from bacteria are resposible for directly destruction. Indirectly destruction is the tissue destruction caused as a response of host tissue against bacterial factors. Bacteria and bacterial metabolic enzymes causes polymorphonuclear leukocytes' migration as chemotatic agent and inflammatuar response occurs by the activation of immunologycal system. Activated polymorphonuclear leukocytes relaeses various reactive oxygen species to protect tissue from microorganisms. The aim of this review is looking at the mechanisms of periodontal tissue destruction and to show the role of the reactive oxygen species in periodontal tissue destruction.
Abstract (Original Language): 
Periodontal hastalıklarda doku yıkımı birkaç mekanizmanın ortak faaliyeti ile direkt ve indirekt olmak üzere iki şekilde gerçekleşir. Dişeti oluğunda ve periodontal cepte kolonize olan bakteriler ve bakterilerden kaynaklı çeşitli enzimler direkt yıkımdan sorumludur. İndirekt yıkım ise konak dokuda bakteriyel faktörlere karşı oluşan doku cevabının meydana getirdiği doku yıkımıdır. Bakteriler ve bakterilerin metabolik enzimleri, kemotaktik ajan olarak polimorfonükleer lökositlerin migrasyonuna yol açmakta, immünolojik sistem aktivasyonu ile enflamatuvar cevap oluşmaktadır. Aktive olmuş polimorfonükleer lökositler dokuyu mikroorganizmalardan korumak amacıyla çeşitli türde reaktif oksijen türlerini salarlar. Bu derlemede amacımız periodontal doku yıkım mekanizmalarına kısaca göz atmak ve reaktif oksijen türlerinin periodontal doku yıkımında oynadığı rolü sunmaktır.
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