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PEKİÜDÜNTİTİSTE DİYETİ CEP SIVISI LDH, AST VE ALP SEVİYELERİNİN KARŞILAŞTIRILMASI

COMPARISON OF LDH, AST, ALP LEVELS IN GINGIVAL CREVICULAR FLUID PERIODONTITIS

Journal Name:

  • Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1997

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Periodontal diseases have been diagnosed and the need for treatment determined on the basis of radiographic assessment of alveolar bone loss, medical and dental history, clinical evaluation including probing pocket depth and attachment loss, the extent of inflammation, microbial deposits and the presence of exudate. there is aneed for objective diagnostic tests that distinguish between disease- active and inactive sites. Aspartate amino transferase and lactate dehydrogenase occurance extracellularly is indicative of cellular necrosis. Changing levels of alkaline phosphatese may be a site-specific indicator of Lhe disease activity. 31 adult and juvenile periodontitis patients and 15 control subjects were involved in our study. The levels of AST^ LDH and ALP in the gingival crevicular fluid and serum were compared and their relationship between clinical indices vvere investigated. In the study, the levels of LDH and AST were significantly higher than the control group,but there was no statistically significant difference in the levels of ALP. As a result, LDH and AST, which are intracellular enzymes, may be useful indicators for the disease activity and for the pathogenesis of the disease.
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Abstract (Original Language): 
Periodontal hastalıkla r vc tedavi planlan alveoler kemik kaybının radyografik olarak değerlendirilmesi, yaş, medikal ve dental anamnez, cep derinliği, ataşman kaybı ölçümlerine, inflamasyon derecesine, mikrobiyal depozitler ve eksudasyon varlığına göre tanımlanmaktadır. Aktif ve inaktif bölgeleri saptamak için objektif diagnostik testlere ihtiyaç vardır. Aspartat aminotransferaz ve laktat dehidrogenazın ekstra sellül er ortamda görülmeleri hücre nekrozunun belirleyicisidir Ayrıca alkalen fosfataz seviyesindeki değişikliklerin, periodontal hastalık aktivitesinrîe bölgesel indikatör olabileceği düşüncesiyle çalışmamızda juvenil ve erişkin periodontitis tanısı konmuş 31 hasla ile 15 sağlıklı bireyde AST, LDH vc ALP enzimlerinin cep sıvısı ve serum seviyeleri karşılaştırılın]5, ayrıca bunların klinik indeksler ile ilişkileri incelenmiştir. Çalışma sonucunda intrascllulcr enzimlerden olan LDH ve AST seviyeleri kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek bulunurken, alkalen fosfataz seviyelerindeki farklar istatistiksel olarak anlamlı değildi. Sonuç olarak, hücre içi enzimlerinden Özellikle LDH ve AST'in periodontal hastalık aktî vitesi indikatörti olabilecekleri ve hastalık palogenezi hakkında bilgi verebilecekleri görülmüştür.
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  • Turkish

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