You are here

TROMBOLİTİK TEDAVİNİN GEÇ DÖNEMİNDE KORONER REPERFÜZYONUNUN ELEKTROKARDİYOGRAFİK BULGULARI

Journal Name:

Publication Year:

Abstract (2. Language): 
We sought the ability of the predischarge electrocardiographic ST segment and T wave changes to predict the patency of infarct related coronary artery in patients with acute myocardial infarction treated with thrombolytic treatment. We included 100 patients who were treated with thrombolytic therapy during the first acute myocardial infarction and who had undergone coronary angiography and left ventriculography before hospital discharge (6th to 12th day). On the predischarge electrocardiography, the ST segment status (either isoelectric or elevated) and T wave status (positive or negative) were determined. Perfusion status of the infarct related artery was determined angiographically within the 6th to 12th days. Results.- ST segment isoelectricity was related to the coronary artery patency with a sensitivity of 84%, specificity of 38%, positive predictive value of 77% and negative predictive value of 50%. On the other hand, sensitivity, specificity, positive and negative predictive values of T wave negativity with regard to the coronary artery patency was 86%, 30%, 73% and 64% respectively. Conclusion.- Patients with isoelectric ST segment and negative T wave on the standard electrocardiography on the 6th-12th days have a higher incidence of patent infarct related coronary artery compared to patients with ST segment elevation and positive T wave who have a higher incidence of non-patent infarct related coronary artery. These findings may be useful in the assessment of risk in the patients with a first acute myocardial infarction treated with thrombolytic therapy before discharge from the hospital.
Abstract (Original Language): 
Bu çalışmada ilk kez akut miyokard infarktüsü saptanan ve trombolitik tedavi alan hastalarda hastaneden çıkış öncesi elektrokardiyografilerinde ST segment ve T dalgası değişikliklerinin koroner arter açıklığı ile ilişkileri değerlendirildi. İlk kez akut miyokard infarktüsü saptanan, trombolitik tedavi alan ve hastaneden çıkmadan önce (6 ve 12. günler arasında) koroner anjiyografi ve sol ventrikülografi yapılan 100 hasta değerlendirmeye alındı. Hastaneden çıkış öncesi elektrokardiyografilerde infarktüs ile derivasyonlarda ST segment durumu (izoelektrik veya yüksek) ve T dalga durumu (pozitif veya negatif ile 6-12. günlerde yapılan koroner anjiyografilerde infarktüs ile ilişkili koroner arterin perfüzyon durumu değerlendirildi. ST segment yüksekliğinin izoelektrik hatta dönmesinin perfüzyonun sağlandığını göstermede %84, spesifite %38, pozitif prediktif değeri %77, negatif prediktif değeri 950 bulundu. T dalgasının negatif olmasının damarda perfüzyon olduğunu göstermede sensitivitesi %86, spesifite 30, pozitif prediktif değeri %73 negatif prediktif değeri %64 bulundu. T dalga negatifliği ST segmenti değişiklikleri dikkate alındığında damar açıklığını belirlemede bağımsız bir faktör olarak bulunmadı. Miyokard infarktüsünün 6-12. günlerinde elektrokardiyografide ST segmenti izoelektrik hatta dönen ve T dalgası negatif olan hastalarda infarktüs ile ilgili damar açıklığı ST segmenti yüksek ve T dalgası pozitif olan hastalardaki damar açıklığı sıklığına göre daha fazladır: ST segmenti yüksek ve T dalgası pozitif olan hastalarda infarktüs ile ilgili damarda yeterli açıklık sağlanamamaktadır. Bu durum hastaların risk belirlenmesinde dikkate alınmalıdır.
33-37

REFERENCES

References: 

Braunwald E. Myocardial reperfusion, limitation of infarct size, reduction of left ventricular dysfunction and improved survival. Should the paradigm be expanded? Circulation 1989; 97: 441-444.
Grancer CB, Califf RM, Topol EJ. Thrombolytic therapy for acute myocardial infarction. Drugs 1992; 44: 293-325.
The GUSTO angiografic investigators. The effect of tissue plasminogen activator, streptokinase, or both on coronary artery patency, ventricular function, and survival after acute myocardial infarction. N Eng J Med 1993; 329: 1615-22.
Popovic AD, Nescovich NA, Babic R, et al. Independent impact of thrombolytic therapy and vessel patency on left ventricular dilatation. Circulation 1994: 90: 800-807.
Galvani M, Ottani F, Ferrini D, et al. Patency of infarct related artery and left ventricular function as the major determinant of survival after Q wave acute myocardial infarction. Am J Cardiol 1993; 71: 1-7.
Vogt A, Essen RV, Tebbe U, et al. Impact of early perfusion status of the infarct related artery on short-term mortality after thrombolysis for acute myocardial infarction: retrospective analysis of four German multicenter studies. J Am Coll Cardiol 1993; 21: 1391-1395.
Rogers J, Baim DS, Gore JM, et al. Comparison of immediate invasive, delayed invasive and conservative strategies after tissue-type plasminogen activator: Circulation 1990; 81: 1457-1476:
Doevendans PA, Gorgels AP, Zee RV, et al. Electrocardiographic diagnosis of reperfusion during thrombolytic therapy in acute myocardial infarction. Am J Cardiol 1995; 75: 1206-1210.
Shah PK, Cercek B, Lew AS, et al. Angiographic validation of bedside markers of reperfusion. Am Coll Cardiol 1993; 21: 55-61.
Kusniec J, Solodky A, Strasberg B, et al. The relationship between the electrocardiographic pattern with TIMI flow class and ejection fraction in patients with a fırst acute anterior wall myocardial infarction. Eur Heart J 1997; 18: 420-425.
Essen RV, Marx W, Effort S. Spontaneous course of ST segment elevation in acute myocardial infarction. Circulation 1979; 59: 105-112.
Antman EM. Braunwald E. Acute myocardial infarction. Heart Disease A Textbook of Cardiovascular Medicine'de Ed. Braunwald E. Philadelphia WB Saunders, 1997; 1184-1288.
Chesebro JH, Knatterud G, Roberts R, et al. Thrombolysis in myocardial infarction (TIMI) trial, phase I. A comparison between intravenous tissue plasminogen activator and streptokinase. Circulation 1987; 76: 142-154.
Matetzky S, Barabash G, Shahar A, et al. Early T wave inversion after thrombolytic therapy predicts better coronary perfusion: Clinical and angiographic study. J Am Coll Cardiol 1994; 24: 378-84.
Özmen F, Kabukçu M, Aytemir K, ve ark. Trombolitik tedaviyi takiben perfüzyon durumunu değerlendirmede elektrokardiyogramda ST segment yüksekliğindeki değişikliklerin değeri. MN Kardiyoloji 1996; 3: 306-312.
Pilote L, Miller DP, Califf RM, et al. Determinants of the use of coronary angiography revascularization after thrombolysis for acute myocardial infarction. N Eng J Med 1996; 335: 1198-1205.
Tzivoni D, Chenzbraun A. The significance of ST abnormalities in myocardial infarction. Cardiol Clin 1987; 5: 419-426.
Özmen F, Kabukçu M, Aytemir K, ve ark. Başarılı trombolitik tedavinin bölgesel ve genel sol ventrikül fonksiyonlarına etkisi. Türk Girişimsel Kardiyol Derg 1997; 1: 60-66.
Maeda S, Kubakı K, et al. Pathologic implications of restored positive T waves and persistent negative T waves Q wave myocardial infarction J Am Coll Cardiol 1996; 28: 1514-1518.

Thank you for copying data from http://www.arastirmax.com