You are here

AKALAZYALI HASTALARDA KLİNİK, RADYOLOJİK VE MANOMETRİK BULGULAR ARASINDAKİ İLİŞKİLER

Journal Name:

Publication Year:

Abstract (2. Language): 
Achalasia is a well known primary motor disorder of the esophagus in which the lower esophageal sphincter (LES) exerts abnormally high resting pressure and incomplete relaxation with swallowing. Dynamic investigations, mainly esophageal manometry and radiological examination are needed for the diagnosis and follow-up after treatment. We present the clinical manifestations, radiological manometric abnormalities of 26 patients with achalasia seen between 1993 and 1997. Results.- Dysphagia was significantly correlated with bird beak deformity and impaired emptying on esophagogram. No significant relationship was found between the LES pressure and clinical and radiological features. Nonperistaltic wave amplitude and LES relaxation were inversely and significantly correlated with impaired emptying on esophagogram. Conclusion.- Radiological findings of achalasia may not be due to hypertensive LES but decreased lower sphincter relaxation may be responsible for dysphagia and impaired esophageal emptying. Also LES pressure is in normal range in 35% of patients with achalasia. Achalasia and hiatal hernia may coexist in 8% of the patients.
Abstract (Original Language): 
Bu çalışmada akalazyalı 26 hastadan elde edilen klinik, radyolojik ve manometrik bulguların birbirleri ile olan ilişkileri korelasyon matriks testi kullanılarak incelendi. Disfaji semptomu özofagogramda tesbit edilen kuş gagası görünümü ve gecikmiş boşalma ile anlamlı korelasyon gösterdi. Alt özefagus sfinkter (AÖS) basıncı ile klinik ve radyolojik bulgular arasında anlamlı korelasyon yoktu. Özefagustaki nonperistaltik dalga amplitüdü ve AÖS relaksasyonunun özofagogramdaki kusurlu boşalma ile negatif anlamlı bir ilişki gösterdiği saptandı. Sonuç olarak, primer özofagus akalazyasındaki radyolojik bulgular sadece artmış AÖS basıncına bağlı olmayabilir ancak azalmış AÖS relaksasyonunun disfaji ve özefagogramdaki gecikmiş boşalmadan sorumlu olabileceği söylenebilir. Akalazya ve hiatal herni hastalarının %8 inde birliktelik göstermiştir.
65-69

REFERENCES

References: 

1. Clouse ER, Diamant NE. Motor physiology and motar disorders of the esophagus. Ed: Sleisenger MH and Fordtran JS. Philadelphia, WB Saunders Comp. 1998; 467-497.
2. Gondenberg SP, Burrell M, Fette GG, et al. Classic and vigorous achalasia: A comparison of manometric, radiographic and clinical findings. Gastroenterol 1991; 101: 734-738.
3. Welsh RW, Drake ST. Normal lower esophageal sphincter pressure. A comparison of rapid vs flow pullthrough techniques. Gastroenterol 1980; 78: 1446-1451.
4. Drake WJ, Hojan WJ, Reid DP, et al. Comparison between primary esophageal peristalsis following wet and dry swallowing. Appl Physiol 1973; 35: 851-857.
5. Orlando RC, Bozymsko EM. The effects of pentagastrin in achalasia and diffuse esophageal spasm. Gastroenterol 1979; 77: 472-477.
6. Dent J. Esophageal manometry. In: Gastrointestinal motility. Which test? Ed: Read NW. Guildford, Wrighstone Publ. 1989; 27-40.
7. Katz P. Esophageal motility disorders. In: Management of gastrointestinal Disease Vol 32. Ed: Winaver S. New York, Gower Med Publ. 1992; 30-43.
8. Fennerty MG, Garevel HS. Esophageal motility. Curr Op Gastroent 1997; 4: 373-379.
9. Cohen S, Harris LD. Does hiatal hexnia affect competence of the gastroesophageal sphincter? N Eng J Med 1971; 284: 1053-1056.

Thank you for copying data from http://www.arastirmax.com