You are here

Home » Content

PEPTİK ÜLSERLİ OLGULARIMIZIN RETROSPEKTİF DÖKÜMÜ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
This study is a retrospective report of cases with endoscopically confirmed peptic ulcer disease diagnosed at the Department of Pediatric Gastroenterology of Cerrahpaşa Medical Faculty within the past 6 years. All patients were evaluated for the use of aspirin or other nonsteroidal anti-inflammatory drugs, the presence of family history and the presence of Helicobacter pylori infection. Results.- Peptic ulcer was found in 41 of 1565 patients who underwent endoscopy. The mean age of the patients was 9±3.7 years (2-14 years), 13 being females. Thirty-two of them were diagnosed as primary and 9 of them secondary ulcer disease. Twenty-two of the primary ulcer patients and 6 of the secondary ulcer patients were males. The majority of cases (32/41) were above 6 years of age at the time of endoscopy. Abdominal pain being prominent (59%) in primary ulcers, hematemesis and/or melena were prominent symptoms (55%) in secondary ulcers. Family, history of peptic disease was obtained in 6 cases. Seven cases had a history of aspirin usage. Sixteen cases were found to be positive for Helicobacter pylori in 22 cases detected. Thirteen of these 16 patients showed duodenal ulceration. Endoscopy revealed gastric ulcers in 15 patients, duodenal ulcers in 22 patients, esophageal + gastric ulcers in one patient, gastric + duodenal ulcers in two patients. Conclusion.- Our patients, majority aged above 6 years (78%) showed male superiority, and had a predominance of primary duodenal ulcers.
Bookmark/Search this post with
Abstract (Original Language): 
Bu çalışma ile son altı yıl içinde Cerrahpaşa Tıp Fakültesi Çocuk Gastroenteroloji Bilim Dalı'nda endoskopi yapılan hastalardaki peptik ülser varlığı retrospektif olarak incelenmek istenmiştir. Tüm hastalarda öyküde aspirin veya non-steroid antienflamatuar ilaç kullanımı, ailede mide yakınmaları ile ilgili öykünün olup olmadığı ve Helicobacter pylori varlığı araştırıldı. Endoskopi yapılan 1565 hastanın 41'inde peptik ülser saptandı. Ülserli olguların 13'ü kız, 28'i erkek olup yaş ortalaması 9 ± 3.7 yıl (2-14 yaş) idi. Olguların 32'si primer, dokuzu sekonder ülser tanısı almıştı. Primer ülserlerin 22'si, sekonder ülserlerin ise 6'sı erkekti. Olguların 32'sinin başvuru yaşı altı yaş ve üzerinde idi. Primer ülserlerde karın ağrısı en önemli başvuru yakınması iken (%59), sekonder ülserlerde hematemez ve/veya melena şeklinde kanama (%55) ön plandaydı. Altı olgunun aile bireylerinin bir veya ikisinde ülser anamnezi vardı. Ülser saptanan olguların yedisinde aspirin alım öyküsü vardı. Olguların 22'sinde Helicobacter pylori araştırılmış ve 16'sında pozitif bulunmuştu. Helicobacter pylori pozitif hastaların 13'ünde duodenal yerleşimli ülser vardı. Kırkbir ülserli olgunun 15'inde midede, 22'sinde duodenumda, birinde özofagus ve midede, birinde özofagus ve duodenumda, ikisinde hem midede, hem de duodenumda ülser saptanmıştı. Ülserli hastalarımızın çoğunluğu altı yaşın üzerinde (%78) olup, erkek üstünlüğü göstermektedir ve literatür ile uyumlu olarak bu yaş grubunda primer duodenal ülserler ön plandadır.
FULL TEXT (PDF): 
PDF icon arastirmax-peptik-ulserli-olgularimizin-retrospektif-dokumu.pdf
  • 2
84-88
  • Turkish

REFERENCES

References: 

1. Rasquin-Weber A. Disorder of the stomach and duodenum. In: Roy CC, Silverman A, Alagille D (eds). Pediatric Clinical Gastroenterology. Mosby-Year Book, Inc, St. Louis, 1995: 174-215.
2. Grybosky JD, Moyer MS. Peptic ulcer in children. In: Wyllie R, Hyams JS (eds). Pediatric Gastrointestinal Disease. WB Saunders Company. Philadelphia 1993:447-467.
3. Singleton EB, Fayhus MH. Incidence of Peptic ulcer as determined by radiologic examination in the pediatric age group. J Pediatr 1964; 65: 858-862.
4. Tam PKH, Saing H, Lau TK. Diagnosis of peptic ulcer in children: The past and the present. J Pediatr Surg 1986; 21: 15-16.
5. Gryboski JD. Peptic ulcer disease in children. Pediatr Rev 1990; 12: 15-24.
6. Nord KS, Rossi TM, Lebenthal E. peptic ulcer in children: The predominance of gastric ulcers. Am J Gastroenterol 1981; 75: 153-157.
7. Cown WK. Genetics of duodenal and gastric ulcer. Clin Gastroenterol 1973; 2: 539-546.
8. Habilbullah CM, Mujahid AM, Isham M, et al. Study of duodenal ulcer disease in 100 families using total serum pepsinogen as a genetic marker. Gut 1984; 25: 1380-1383.
9. Vreeburg EM, De Bruijne HW, Snel P, Bartelsman JW, Rauws EA, Tytgat GN. Previous use of non-steroidal anti-inflammatory drugs and anticoagulants: the influence on clinical outcome of bleeding gastroduodenal ulcers. Eur J Gastroenterol Hepatol 1997; 9: 41-44.
10. McNulty CAM, Gearty JC, Crump B, et al. Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J 1986; 293: 645-649.
11. Mahony MJ, Wyatt JI, Littlewood JM. Campylobacter pylori gastritis. Arch Dis Child 1988; 63: 654-655.
12. Price AB, Levi J, Dolby M, et al. Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology, and scanning electron microscopy. Gut 1985; 26: 1183-1188.
13. Macarthur C, Saunders N, Feldman W. Helicobacter pylori, gastroduodenal disease, and recurrent abdominal pain in children. JAMA 1995; 273:729-734.
14. Kutlu T, Çullu F, Tümay TG, ve ark. Çocuklarda Helicobacter pylori enfeksiyonunun tanı ve tedavisi. İst Çocuk Klin Derg 1994; 29: 230-235.
15. Desforges JF. Helicobacter pylori and peptic ulcer disease. N Engl J Med 1991; 324: 1043-1049.
16. Schubert TT, Bologna SD, Nensey Y, Schubert AB, Mascha EJ, Ma CK. Ulcer risk factors: interactions between Helicobacter pylori infection, nonsteroidal use, and age. Am J Med 1993; 94: 13-18.
17. Adamek RJ, Freitag M, Opferkucli W, Ruhl GH, Wegener M. Intravenous omeprazole/ amoxicillin and omeprazole pretreatment in Helicobacter pylori-positive acute peptide ulcer bleeding. A pilot study. Scand J Gastroenterol 1994; 29: 880-883.
18. Henriksson AE, Edman AC, Held M, Wadstrom T. Helicobacter pylori and acute bleeding peptic ulcer. Eur J Gastroenterol Hepatol 1995; 7: 769-771.
19. Tytgat GN. Peptic ulcer and Helicobacter pylori: eradication and relapse. Scand J Gastroenterol (Suppl) 1995; 210: 70-72.
20. Rauws EJ, Tytgat GN. Helicobacter pylori in duodenal and gastric ulcer disease. Baillieres Clin Gastroenterol 1995; 9: 529-547.
21. McColl KEL, El-Nujumi AM, Chittajallu RS, et al. A study of the pathogenesis of Helicobacter pylori negative chronic duodenal ulceration. Gut 1993; 34: 762-768.
22. Bujanover Y, Reif S, Yahav J. Helicobacter pylori and peptic disease in the pediatric patient. Pediatr Clin North Am 1996; 43: 213-234.
23. Bourke B, Jones N, Sherman P. Helicobacter pylori infection and peptic ulcer disease in children. Pediatr Infect Dis J 1996; 15: 1-13.
24. Prieto G. Polanco I, Larraui J, et al. Helicobacter pylori infection in children. Clinical, endoscopic and histologic correlations. J Pediatr Gastroenterol Nutr 1992; 14: 420-425.
25. Mitchell HM, Bohane TD, Tobias V, et al. Helicobacter pylori infection in children: Potencial clues to pathogenesis. J Pediatr Gastroenterol Nutr 1993; 16: 120-125.
26. Erkan T, Kutlu T, Çullu F, Göksel S, Tümay TG. Üst gastrointestinal sistem kanama ile gelen çocuklarda Helicobacter pylori sıklığı. KIinik Gelişim 1998; 11: 465-468.

Thank you for copying data from http://www.arastirmax.com