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KOLOREKTAL KANSERDE METASTAZIN SERUM TOTAL SİYALİK ASİT DÜZEYLERİ ÜZERİNE ETKİSİ

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Abstract (2. Language): 
This study was designed to asses the effect of metastasis on serum total sialic acid level in patients with colorectal cancer. Results.- We measured serum total sialic acid (TSA) level by using Warren’s thiobarbituric acid assay. TSA levels in healthy control, colorectal cancer without metastasis and colorectal cancer with metastasis were found as 73.2 ± 6.0 ; 73.7 ± 5.0 ; and 96.0 ± 9.0 mg NANA/dL respectively. Statistical difference between metastasis and the other two groups was significant (p < 0.001). Conclusion.- According to our results, metastasis causes the increase of serum TSA levels. We suggest that the determination of this increase may be useful for the evaluation of a possible metastatic involvement.
Abstract (Original Language): 
Bu çalışmada Haydarpaşa Numune Eğitim Hastanesi 2. Dahiliye Kliniği’nde tanısı koyulmuş, 60 (36 erkek , 24 kadın) kolorektal kanser olgusu 20 kişiden oluşan sağlıklı kontrol grubu ile serum TSA düzeyleri bakımından karşılaştırılmıştır. TSA düzeyleri Warren’in tiobarbitürik asid yöntemine göre ölçülüp, kontrol grubu, metastazı olmayan kolorektal kanser ve metastazlı grup için sırasıyla 73,2 ± 6,0; 77,60 ± 5,0 ve 96,0 ± 9,0 mg NANA/ dL olarak bulunmuştur . Kontrol grubu ile metastazı olmayan grup arasında istatistiksel olarak anlamlı bir farklılık bulunmazken (p > 0,05) , metastazlı grupta her iki gruba göre anlamlı düzeyde artışlar saptandı (p < 0,001). Elde ettiğimiz bulgulara göre metastaz serum TSA düzeylerinin artışına neden olmaktadır. Bu artışın saptanmasının olas ı bir metastaz varlığını değerlendirmede faydalı olabileceği kanısındayız.
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REFERENCES

References: 

1. Erbil KM, Jones JD, Klee GG. Use and limitations
of serum total and lipid-bound sialic acid
concentrations as markers for colorectal cancer.
Cancer 1985; 55: 404-409.
2. Verazin G, Riley WM, Gregory J, Tautu C, Prorok
JJ, Alhadeff JA. Serum acid sialic and carcinoembryonic
levels in the detection and monitoring
of colorectal cancer. Dis Colon Rectum
1990; 33: 139-142.
3. Kökoğlu E, Sönmez H, Usl E, Uslu I. Sialic acid
levels in various types of cancer. Cancer Biochem
Biophys 1992;13: 57-64.
4. Friedman J, Levinsky H, Allalouf D, Staroselsky
A. Sialic acid content in mouse myeloma cells
and derived B-cell hybridomas with different
metastatic potentials. Cancer Lett 1988; 43: 79-
84.
5. Jaques LW, Brown EB, Barret JM, Brey WS,
Weltner W Jr. Sialic acid: a calcium binding carbohydrate.
J Biol Chem 1977; 252: 4533-4538.
6. Yeşilkaya Y, Şahin M, Harmanda R, Oğan MN,
Sözüer AM. Kolon ve rektum kanserinin klinik
analizi. Kolon Rektum Hast Derg 1992; 2: 137-
140.
7. Narayanan S. Sialic acid as a tumor marker. Ann
Clin Lab Sci 1994;24: 376-384.
8. Schauer R. Sialic acids and their role as a biological
masks. Trends Biochem Sci 1985; 10: 357-
360.
9. Warren L. The thiobarbituric acid assay of sialic
acids. J Biol Chem 1959; 234: 1971-1975.
10. Raz A,Bucana C, McLellan W, Fidler IJ. Distrubution
of membrane anionic sites on B16 melanoma
variants with differing lung colonising
potential. Nature 1980; 284:363-364.
11. Ganzinger U and Deutsch E. Serum sialytransferase
levels as a parameter in the diagnosis
and follow up of gastrointestinal tumors. Cancer
Res 1980; 40:1300-1304.
12. Griffiths J and Reynolds S. Plasma sialy transferase
total and isoenzyme activity in the diagnosis
of cancer of the colon. Clin Biochem;
1982;15: 46-48.
13. Dwivedi C, Dixit M, Hardy RE.Plasma sialyltransferase
as a tumor marker. Cancer Detect
Prev 1988; 11: 191-196.
14. Ganzinger U, Dorner F, Unger FM, Moser K,
Jentzsh K. Elevated serum-sialytransferase activity
in human malignant diseases: a new diagnostic
tool ? Klin Wochenschr 1977; 55: 553-555.
15. Berge PG, Wilhelm A, Schriewer H, Wüst G.
Serum-sialyltransferase activity in cancer patients.
Klin Wochenshr 1982; 60: 445-449.
16. Akamatsu S, Yazawa S, Tachikawa T, Furuta T,
Okaichi Y, Nakamura J, Asao T, Nagamachi Y.
a2 -->3 Sialytransferase associated with the synthesis
of Ca 19-9 in colorectal tumors. Cancer
1996; 77: 1694-1700.
17. Dall’Olio F, Malagolini N, Di Stefano G, Minni
F, Marrano D, Serafini-Cessi F. Increased CMPNeuAc:
Gal(1 , 4GlcNAc-R (2,6 sialytransferase
activity in human colorectal cancer tissues. Int J
Cancer 1989; 44: 434-439.
18. Akçay T, Konukoğlu D, Erörenci A, Ataus S,
Dirican A, Uygur C. Urinary excretion of sialic
acid in patients with superficial bladder tumors.
Cancer Lett 1994; 78: 7-9.
19. Shanmugam V, Nagrajan B. Prognostic significance
of lipid bound sialic acid in sera of cancer
patients. Indian J Cancer1986; 23: 173-177.
20. Liu HP, Yang ZS, Zhang SS. The application of
leukocyte adherence inhibition assay to patients
with colorectal cancer. Comparison with serum
level of carcinoembryonic antigen and sialic
acid.Dis Colon Rectum 1989; 32: 210-213.
21. Stefenelli N, Klotz H, Engel A, Bauer P. Serum
sialic acid in malignant tumors, bacterial infections
and chronic liver diseases. J Cancer Res
Clin Oncol 1985; 109: 55-59.
22. Tewarson SL, Mittal VP, Singh M, Gupta GP.
Serum sialic acid : an important cancer marker.
Indian J Cancer 1993; 30: 125-131.
23. SilverHKB, Karim KA, Salinas FA, Swenerton
KD. Significance of sialic acid and carcinoembriyonic
antigen as monitors of tumor burden
among patients with carcinoma of the ovary.
Surg Gynecol Obstet 1981; 153: 209-213.
24. Shamberger RJ. Serum sialic acid in normals
and in cancer patients. J Clin Chem Clin Biochem
1984; 22: 647-651.
25. Dabrowska B, Krasnodebski IW, Tadeusiak W.
Sialic acid and carcinoembyonic antigen (CEA)
as markers of colon cancer: Preliminary report.
Pol Tyg Lek 1991; 46: 890-891.
26. Polivkova J, Vosmikova K, Pospisil K, Pouckova
P. Relation between lipid-bound sialic acid in
blood serum and plasma and in human tumors.
Bratisl Lek Listy 1992; 93: 222-224.
27. Greaves P, Filipe MI, Branfoot AC.Transitional
mucosa and survival in human colorectal cancer.
Cancer 1980; 46: 764-770.
28. Katopodis N, Hirshaut Y, Geller NL, Stock CC.
Lipid-associated sialic acid test for detection of
human cancer. Cancer Res 1982; 42: 5270-5275.
29. Dnistrian AM, Scwartz MK. Plasma lipid-bound
sialic acid and carcinoembryonic antigen in cancer
patients.Clin Chem 1981; 27: 1737-1739.
30. Dwivedi C, Dixit M, Hardy RE. Plasma lipidbound
sialic acid alterations in neoplastic diseases.
Experientia 1990; 46: 91-94.
31. Creperio G, Familiari G, Ranzini C. Variations
in serum sialic acid in patients operated on for
colonic cancer.Minerva Med 1985; 76: 1851-
1853.
32. Krasnodebski IW. Usefulness of biochemical
tumor markers (CEA,Ca 19-9, ferritin and sialic
acid) in diagnosis and prognosis of colonic neoplasms.
Wiad Lek 1998;51:132-141.
33. Bresalier RS, Rockwell RW, Dahiya R, Duh Qy,
Kim YS. Cell surface sialoprotein alterations in
metastatic murine colon cancer cell lines selected
in an animal model for colon cancer metastasis.
Cancer Res 1990;15:1299-1307.
34. Otsuka K, Ohkuma S, Nakajima T. Isolation
and partial characterization of two glycoproteins
from human liver metastases of sigmoid colon
carcinoma. Int J Biochem 1990; 22: 653-658.
35. Irimura T, Carlson DA, Price J, Yamori T,
Giavazzi R, Ota DM, Cleary KR. Differential
expression of a sialoglycoprotein with an approximate
molecular weight of 900,000 on metastatic
human colon carcinoma cells growing in
culture and in tumor tissues. Cancer Res 1988;
48: 2353-2360.

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