You are here

Home » Content

MONOSEMPTOMATİK KLEINE-LEVIN SENDROMU: Bir Olgu Sunumu

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Kleine-Levin syndrome is characterized by recurring episodes of hypersomnia, mental disturbances and abnormal behaviour including hyperphagia and hypersexuality. The episodes start suddenly generally after a mild viral infection, mild head injury or sometimes after a psychological stress. They last few days to several weeks and end abruptly. Between the episodes, there is no sleep disturbance and patients are physically and mentally normal. Patients sleep as long as 18 to 20 hours of the day during the episode. Hyperphagia and/or hypersexuality. are in compulsive manner. Mental disturbances include, irritability, feeling of unreality or confusion. Recently, monosymptomatic and atypic forms of the syndrome were reported. In monosymptomatic form, hypersomnia occurs without hyperphagia and hypersexuality. Atypical Kleine-Levin Syndrome includes the forms where one of the symptom is replaced by an opposite one. Observation.- The clinical course of 19 year old boy with recurrent 3 episodes of hypersomnia and mental disturbances during a period of 3 months was presented. Episodes were occurred after mild viral infections or psychological stress. Electroencephalographic, and polysomnographic data supported the diagnosis of ‘’Monosymptomatic Kleine Levin Syndrome’’ and no episode has occurred with the prophylactic treatment of Lithium carbonate during last 6 months period.
Bookmark/Search this post with
Abstract (Original Language): 
Kleine-Levin Sendromu, periyodik olarak ortaya çıkan hipersomni, mental bozukluklar ve hiperfaji, hiperseksüelite gibi davranış bozuklukları ile şekillenen bir sendromdur. .Son yıllarda bu sendromun hiperfaji veya hiperseksüalite eşlik etmeksizin sadece hipersomni ve mental bozukluklar ile seyreden monosemptomatik formunun veya hipersomniye eşlik eden semptomların tam tersi semptomlar olarak ortaya çıktığı atipik formlarının da olduğu gösterilmiştir. Bu yazıda, 3 ay içinde 3 kez ortaya çı- kan, 3-4 hafta aralıklarla tekrarlayan, or- talama 1 hafta süren, günde 18 saati aşan süreli uyku, ve irritabilite, algılama bozukluğu şeklinde mental semptomlar gösteren 19 yaşında bir erkek hasta sunulmuştur. Yapılan tüm kan, BOS ve radyolojik tetkiklerde, santral sinir sisteminin tutulumunu gösteren herhangi bir enfeksiy öz, paraenfeksiyöz, metabolik, vasküler ve enflamatuar bulguya rastlanmamış, psikiyatrik muayenesi normal olarak değerlendirilmiştir. Yaş, cinsiyet, atakların özellikleri gözönüne alınarak monosemptomatik Kleine-Levin Sendromu tanısı konulan hastada bu tanı atak sırasında yapılan rutin EEG ve polisomnografik tetkikler ile de desteklenmiştir. Lityum 3 x 300 mg/gün proflaktik tedavisi ile hastada son 6 aydır yeni bir atak gözlenmemiştir.
FULL TEXT (PDF): 
PDF icon arastirmax-monosemptomatik-kleine-levin-sendromu-bir-olgu-sunumu.pdf
  • 4
243-248
  • Turkish

REFERENCES

References: 

1. Roth B, Nevsimalova S. The clinical picture of
periodic hypersomnia. Sleep 1980; 5th Eur
Congr Sleep Res, Amsterdam 1980; 120-124.
Karger,Basel 1981.
2. Lemiere I. Revue du syndrome de Kleine-Levin:
vers une approche integree. Revue can de psychiatrie
1993; 38: 277-284.
3. Gallicek A. Syndrome of episodes of hypersomnia,
bulimia, and abnormal mental states.
JAMA 1954; 154: 1081-1083.
4. Critchley M. Periodic hypersomnia and megaphagia
in adölescent males. Brain 1962; 85: 627.
5. American Sleep Disorders Associatio. International
Classification of Sleep Disorders, Revised:
Diagnostic and Coding Manual. Rochester, Minnesota:
American Sleep Disorders Association
1997; 43-46.
6. Chesson AL, Levine SN, Kong LS , Lee SC. Neuroendocrine
evaluation in Kleine-Levin syndrome:
evidenced of reduced dopaminergic during
periods of hypersomnolence. Sleep 1991; 38:
277-284.
7. Klob W, Meier-Ewart K. Das Kleine-Levin
syndrome-eine funktionelle Zwischenhirnst
örüng? Psycho 1983; 602-608.
8. Carpenter S, Yassa R, Ochs R. A pathologic basis
for Kleine-Levin syndrome. Arch Neuro 1982;
39: 125-128.
9. Takrani LB, Cronin D. Kleine-Levin syndrome in
a female patient. Can Pschiatr Assoc J 1965; 21:
315-318.
10. Gadoth N, Dickerman Z, Bechar M, Laron Z,
Lavie P. Episodic hormone secretion during
sleep in Kleine-Levin syndrome: evidence for
hypothalamic dysfunction. Brain Dev 1987; 9:
309-315.
11. Romero O, Sagales T, Gimeno V, Cordoba J.
Phase advancement of slow wave sleep in a patient
with periodic hypersomnia. Sleep 1995; 18:
206-208.
12. Reynolds CF III, Kupfer DJ, Christiansen CL.
Multipl sleep latency test findings in Kleine
Levin syndrome. J Nerv Ment Dis 1984; 172:
241.
13. Kaynak H, Gürdal A, Gözükırmızı E, Dektaş H.
Neuropsychiatric features in recurrent hypersomnia.
J. Sleep Res 1994; 3 (Supplement 1):
123.
14. Kaynak H, Gözükırmızı E, Gürdal A, Damcı D,
Narlı H, Dektaş H. Treatment in recurrent hypersomnia:
a follow-up study. J Sleep Res 1995;
24: 263.

Thank you for copying data from http://www.arastirmax.com