Journal Name:
- Cerrahpaşa Tıp Dergisi
Keywords (Original Language):
| Author Name | University of Author | Faculty of Author |
|---|---|---|
Abstract (2. Language):
New equipments
and methods which will be crucial in
decreasing hemolyze rate have been experienced
for the last years. For this reason,
the equipments that are used in cardiopulmonary
bypass (CPB) must show similarities
to biological tissues. Thats because,
those equipments must be coated with immobilize
heparin and thus it must be worked
for gaining them similar attributes with vessel
endothel. The aim is to decrease the
mortality rate of operation incidence by decreasing
contraindications result from CPB.
1) In the operations that make up the control
group, full dose of systemic heparinization
(4,0 mg/kg) with uncoated CPB system
(UCS) was used.
2) In the experiment group, low dose systemic
heparinization (1,5 mg/kg) with heparin
coated CPB system (HCS) was used.
Results.- By taking the levels of free
plasma hemoglobin (FpHb) in to consideration,
the differences occurred in different
stages within each group and the differences
in same stages between opponent
groups were observed.
In both HCS, UCS, and 30 mins after the
operation, FpHb level started to gradually
increase from the preoperative period level.
In HCS, FpHb level stayed constants from
the beginning of the third period, and it decreased
to period level after the fifth stage.
In UCS, the level increased excessively until
the forth period and then the level decreased
gradually.
Conclusion.- FpHb levels of the UCS group
were found to be statistically significantly
higher than the HCS group in every stages
of the than stage 1. (p<0.05).
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Abstract (Original Language):
Açık kalp cerrahisinde Heparin Kaplı
Olmayan (HKOS) kardiyopulmoner bypass
sistemleri (KPB), yaygın olarak kullan
ılmaktadır. Bu, operatif ve postoperatif
dönemlerde çok ciddi komplikasyonlara
neden olmaktadır. Bu komplikasyonlardan
biriside eritrositlerde hemolize neden
olarak, Serbest plazma Hemoglobin
(SpHb) seviyesini artırmasıdır. Yeni geliştirilen
Heparin Kaplı (HKS) KPB sistemlerinin
bu komplikasyonları azaltacağı ileri
sürülmektedir. Çalışmalarımızda; ameliyatlar
ında heparin kaplı KPB sistemleri +
düşük doz (1,5 mg/kg) sistemik heparinizasyon
kullandığımız olguların SpHb
seviyeleri, heparin kaplı olmayan KPB
sistemleri + full doz (4,0 mg/kg) sistemik
heparinizasyon kullanılan olgulara oranla
istatistiksel olarak düşük bulunmuştur.
Sonuçlarımız bize; KPB esnasında vücu-
dun geliştirdiği humoral ve hücresel cevap
aktivasyonundan kaynaklanan hemoliz
olayının, heparin kaplõ KPB sistemlerinin
kullanılmasıyla daha aza indirilebileceğini
düşündürmektedir.
FULL TEXT (PDF):
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