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CURCUMİN'İN STRES ÜLSERLERE ETKİSİ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Curcumin is a phenolic compound known with its antioxidant properties. In this study we have evaluated if curcumin has antiulcerogenic properties as well. For the study twenty wistar rats were evaluated. Brodie’s immobility method was performed for inducing stress ulcers. Sialic acid, a component of mucus glycoproteins, protects gastric mucosa against ulcerogenic stress, via conferring resistance against proteolytic cleavage. Sialic acid determination was performed according to thiobarbituric acid assay of Warren. Results.- We have evaluated sialic acid levels in gastric mucosa and plasma of rats. In the rats fed with curcumin dissolved in sesame oil, neither plasma nor mucosal sialic acid levels did not significantly differ from rats, which only fed sesame oil (p>0.05). Conclusions.- Any protective effect against stress ulcers was not found for curcumin and hence an antioxidant property alone could not significantly modulate this process.
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Abstract (Original Language): 
Curcumin antioksidan özellikleri ile tanınan fenolik yapıda bir maddedir. Mukus glikoproteinlerinin yapısında yer alan siyalik asid mukozay ı proteolitik yıkıma karşı korur. Bu çalışmada curcuminin ülser oluşumunda etkisi olup olmadığı incelendi. Bu çalışmada 20 Wistar Albino soyu sıçanda Brodie’nin hareketsizlik modeli ile stres ülser oluşturularak mide mukoza ve plazma siyalik asid düzeyleri tayin edildi. Siyalik asid ölçümleri Warren’in tiyobarbitürik asid metodu ile yapıldı. Curcumin ile beslenen sıçanların plazma ve doku siyalik asid düzeyleri susam yağı ile beslenen gruba göre farklı olmadığı tespit edildi (p>0.005). Çalışmanın sonucunda curcuminin stres ülserlere karşı koruyucu etkisi olmadığı, bu ülser oluşumunun antioksidan mekanizma ile açıklanamayacağı, ortaya çıkmıştır.
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  • 2
93-96
  • Turkish

REFERENCES

References: 

1. Cheung LY. Pathogenesis, prophylaxis and treatment of
stress gastritis. Am J Surg 1988; 156:437-440.
2. Merserau WA, Hinshey EJ. Effect of gastric acidity on
gastric ulceration induced by heamorrhage in the rat
,utilizing a gastric chamber technique. Gastroenterology
1973; 64:1130-1135.
3. Salim AS. Removing oxygen derived free radicals
stimulates healing of ethanol induced erosive gastritis in
the rat. 1990; 47: 24-28.
4. Andrews FJ, Malcontenti C, O’Brien PE: Seguence of
gastric mucosal injury following ischemia and
reperfusion: The role of reactive oxygen metabolites.
Gastroenterology 1991;100:25.
5. Smith SM, Grisham MB. Gastric mucosal injury in the
rat. Role of iron and xanthine oxidase. Gastroenterology
1987;92:950-956.
6. Kunchandy E, MNA Rao. Oxygen radical scavenging
activity of curcumin. Int J Phameceut 1990;58:237-240.
7. Srivastava R, Srimal RC. Modification of certain
inflammation induced biochemical changes by curcumin.
Indian J Med Res 1985;81:215-223.
8. Awasthi S, Srivastawa SK, Piper JT, Singhal SS,
ChaubeyM, AwasthiYC. Curcumin protects against 4-
hydroxy-2-trans-nonenal-induced cataract formation in
the rats lenses. Am J Clin Nutr 1996; 64:761-766.
9. Gali HU, Perchellet EM, Kish DS, Perchellet JM.
Hydrolyzable tannins: potent inhibitors of hydroperoxide
production and tumor promotion in mause skin treated
with 12-O- tetradecanoylphorbol-13-acetate in vivo. Int J
Cancer 1992; 51: 425-432.
10. Sharma OP. Antioxidant activity of curcumin and related
compounds. Biochemical Pharmacology 1976; 25: 1811-
1812.
11. Schauer R. Sialic acids. Trends Biochem 1985;7:357-
360.
12. Somasundaram K, Ganguly AK. Gastric mucosal
protection during restraint stress in rats: alteration in
gastric adherent mucus in gastric secretion.
Hepatogastroenterology 1985;32:24-26.
13. Parker N, Tsai HH, Ryder SD, Raouf AH, Rhodes JM.
Increased rate of sialylation of colonic mucin by cultured
ulcerative colitis mucosal explants. 1995; 56:52-56.
14. Sobhani I, Denizot Y, Hoclaf S, Rigaut D, Vatier J,
Benveniste J, Lewin MJ, Mignon M. Gastric secretion of
platelet activating factor and precursors in healthy
humans:effect of pentagastrin. Gut 1993;34:1051-1056.
15. Brodie DA, Hanson HM. A study of the factors involved
in the production of gastric ulcers by the restraint
technique. Gastroenterology 1960;38:353-360.
16. Warren L. The thiobarbituric acid assay for sialic acid. J
Biol Chem 1959;234:1971-1976.
17. Priyadarsini KI. Free radical reactions of curcumin in
membrane models. Free Radic Biol Med 1997;23:838-
843.
18. Subramanian M, Sreejayan N, Rao MNA, Devsagayam
TPA, Singh BB. Diminution of singlet oxygen-induced
DNA damage by curcumin and related antioxidants.
Mutat Res 1994;311:249-255.
19. Barry Halliwell and John M C Gutteridge. Free Radicals
in Biology and Medicine, Third edition p 646,647,
Oxford, University Press, 2000.
20. Ahmad F, McPhie P. The intrinsic viscosity of
glycoproteins. Int J Biochem 1980;11:91-96.
21. Schauer R. Chemistry, metabolism and biological
functions of sialic acids. Advances in carbohydrate and
biochemistry 1985;40:218-219.
22. Okajima K, Oyama H, Kimura K, Maeda K, Obata S,
Ogata Y, Okabe H, Koga S, Takatsuki K.Plasma
concentration of polymorphonuclear leukocyte elastasealpha-
1-proteinase inhibitor complex in patients with
gastric ulcer. Rinsho Byori 1990; 38: 901-905.
23. Vatier J,Poitevin C, Pasquier MC, Vitre MT, Olivier A,
Sfedj D, Mignon M.Gastric functional exploration.
Comparison between secretory results in 72 non-ulcer
dypeptic patients and 289 non-operated duodenal ulcer
patients. Predictive criteria for the efficacy of fundus
vagotomy in duodenal ulcer.Gastroenterol Clin Biol
1991;15:727-734.
24. Vatier J, Poitevin C, Mignon M. Sialic acid content and
proteolytic activity in gastric juice in humans. An
approach for appreciating mucus glycoprotein
erosion.Dig Dis Sci 1988; 33: 144-151.
25. Vatier J, Poitevin C, Mignon M. Is the reduction of the
intragastric output of sialic acid bound to glycoproteins of
the mucus an index to its gastric protective effect?
Gastroenterol Clin Biol 1987;11:483-487.

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