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c-fos Geni ve Fos Proteinleri

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
c-fos is a gene that is transcribed temporarily and rapidly by factors that cause growth and differentiation by affecting cells. Fos proteins are nuclear proteins that are produced by c-fos gene. c-fos is considered to be a third nuclear messenger. The expression and accumulation of c-fos gene, a protooncogen that is a member of IEG (Immediate Early Gene) group, and Fos proteins, a member of AP-1 (Activator Protein-1) family oncoproteins, upsurge along with cellular activation under the affect of certain stimuli. This gene and proteins play a very important role during cellular proliferation, differentiation and programmed cell death (apoptosis). The c-fos gene and Fos proteins, being a potential activator of transcription, are a key to understand congenital anomalies, oncogenic transformation and normal development due to their relationship with abovementioned biological processes.
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Abstract (Original Language): 
c-fos, Hücreleri etkileyerek büyüme ve farklılaşmayı sağlayan etkenler tarafından hızlı ve geçici transkripsiyonu sağlanan genlerdendir. Fos proteinleri de c-fos geninin ürünü olan çekirdek proteinleridir. c-fos Çekirdeksel üçüncü ulak olarak değerlendirilir. IEG (İmmediate Early Gene) grubundan bir protoonkojen olan c-fos geni ve AP-1 (Activator Protein-1) ailesi üyesi onkoproteinlerden olan Fos proteinlerinin ekspresyonu ve birikimi çeşitli uyarılara yanıt olarak hücre aktivasyonu ile birlikte artar. Bu gen ve proteinler hücre çoğalması, farklılaşması ve programlı ölümünde (apoptosis) en önemli rolü oynamaktadırlar. Transkripsiyonun potansiyel aktivatörü olan c-fos geni ve Fos proteinleri bu biyolojik süreçlerle ilgisi yüzünden özellikle doğumsal anomalilerin, onkojenik transformasyonun ve normal gelişimin değerlendirilmesinde önemli bir anahtardır.
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