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SIÇAN TİROİD BEZİNDE KADMİYUM HASARINA KARŞI C VİTAMİNİ, E VİTAMİNİ VE SELENYUMUN KOMBİNE KULLANIMININ ETKİLERİ

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Abstract (2. Language): 
Histopathological alterations to various organs of the different species in acute and chronic cadmium exposure have been studied by light and electron microscopy. Metallothionein is a protein inducible by heavy metal ions. The aim of this study was to determine the effects of vitamin C, vitamin E and selenium combination on the cadmium-induced morphological and immunohistochemical changes in the thyroid gland of adult male rats. Results.- In the group given cadmium, the degenerative changes were observed in the thyroid gland. In addition, an increase in the number of metallothionein positive cells was detected in this group. These immunoreactive cells were identified as mast cells. While these degenerative changes and metallothionein immunoreactive cells in the thyroid gland were decreased in the group given cadmium and antioxidants according to the experimental group.
Abstract (Original Language): 
Çalışmanın amacı sıçan tiroid bezinde kad-miyumun sebep olduğu hasara karşı C vitami-ni, E vitamini ve selenyumun koruyucu bir et-kisinin olup olmadığını incelemek ve metallo-tionein ekspresyonunu tespit etmekti. Grup I: Dokunulmamış sıçanlardan; Grup II: 8 gün oral olarak sadece C vitamini (250 mg/kg/gün), E vitamini (250 mg/kg/gün) ve sodyum selenat (0.25 mg/kg/gün) verilen sıçanlardan; Grup III: İntraperitoneal olarak CdCl2 (2 mg/kg/gün) ve-rilen sıçanlardan; Grup IV: Kadmiyum veril-mesinden 1 saat önce, aynı zaman ve dozda C vitamini, E vitamini ve selenyum verilen sıçan-lardan oluşturuldu. Sıçanların tiroid bezinden alınan doku parçaları rutin takipleri yapıldıktan sonra, histolojik ve immunohistokimyasal ola-rak incelendi. Sonuç olarak, kadmiyumun tiro-id bezinde yapısal dejeneratif değişikliklere se-bep olduğunu, bu antioksidanların tiroid be-zinde kadmiyum ile oluşan oksidatif hasara karşı koruyucu bir etki gösterdiğini ve metallo-tionein ekspresyonunun düzenlenmesine katkı-da bulunabileceğini söyleyebiliriz. Ayrıca, çok sayıda metallotionein pozitif hücre içeren tiro-id bezinin kadmiyum birikimi ile ilgili olduğu ve metallotioneinin de bu birikimde rolu oldu-ğu düşünülmektedir.

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Teşekkür: Bu çalışma İstanbul Üniversitesi Rektörlüğü Bilimsel Araştıma Projeleri Yürütücü Sekreterliği tarafın-dan (proje no: 1601/30042001) desteklenmiştir.

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