You are here

Home » Content

Konjenital Herpes Simpleks Virüs İnfeksiyonu

Congenital Herpes Simplex Virus Infection

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Neonatal herpes simplex virus (HSV) infection can result in serious morbidity and mortality. Neonatal HSV infection usually is acquired during the birth process, as the neonate comes in contact with the virus during passage through an infected canal. After an incubation period which can last as long as 2 to 4 weeks, neonatal HSV disease then manifests in 1 of 3 ways: (1) disseminated disease, with visceral organ involvement; (2) central nervous system disease; or (3) disease limited to the skin, eyes, and/or mouth. The diagnosis of neonatal HSV can be difficult, but it should be suspected in any newborn with irritability, lethargy, fever or poor feeding at one week of age. Diagnosis is made by culturing the blood, cerebrospinal fluid, urine and fluid from eyes, nose and mucous membrans. Treatment of neonatal HSV disease with intravenous acyclovir has improved the likelihood of survival substantially, although neurologic morbidity remains common sequelae, especially among survivors of central nervous system disease. The surest way to improve outcomes rapidly at this point is to raise awareness of neonatal HSV disease, resulting in the establishment of earlier diagnoses and more rapid institution of antiviral therapy.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-konjenital-herpes-simpleks-virus-infeksiyonu.pdf
  • 1
24 - 31
  • Turkish

REFERENCES

References: 

1. Arvin AM: Herpes Simplex Viruses 1 and 2. In:
Feigin RD, Cherry JD, Demmler GJ; eds. Textbook
of Pediatric Infectious Diseases. 5th ed. Philadelphia,
PA, IL: Elsevier Saunders; 2004: 1884-1912.
2. Arvin AM, Whitley RJ, Gutierrez KM: Herpes Simplex
Virus Infections. In: Remington SS, Klein JO; eds.
Infectious Diseases of the Fetus and Newborn Infant.
6th ed. Philadelphia, PA, IL: Elsevier Saunders;
2006: 845-865.
3. Stevens JG, Cook ML. Latent herpes simplex virus
in spinal ganglia of mice. Science 1971; 173: 843-
845.
4. Kimberlin DW, Whitley RJ. Neonatal herpes: what
have we learned. Semin Pediatr Infect Dis 2005;
16: 7-16.
5. Whitley RJ. Neonatal herpes simplex virus infections.
Clin Perinatol 1988; 15: 903-916.
6. Rudnick CM, Hoekzema GS. Neonatal herpes
simplex virus infections. Am Fam Physician 2002;
65: 1138-1142.
7. Sullender WM, Miller JL, Yasukawa LL, et al. Humoral
and cell-mediated immunity in neonates with
herpes simplex virus infection. J Infect Dis 1987;
155: 28-37.
8. Burchett SK, Corey L, Mohan KM, et al. Diminished
interferon-gamma and lymphocyte proliferation in
neonatal and postpartum primary herpes simplex
virus infection. J Infect Dis 1992; 165: 813-818.
9. American Academy of Pediatrics. Herpes Simplex.
In: Pickering LK, Baker CJ; eds. 2006 Red Book
Report of the Committee on Infectious Diseases.
27th ed. Elk Grave Village, IL: American Academy
of Pediatrics; 2006: 361-371.
10. Andrews WW, Kimberlin DF, Whitley R, et al.
Valacyclovir therapy to reduce recurrent genital
herpes in pregnant women. Am J Obstet Gynecol
2006; 194: 774-781.
11. Dan M, Sadan O, Glezerman M, et al. Prevalence
and risk factors for herpes simplex virus type 2 infection
among pregnant women in Israel. Sex Transm
Dis 2003; 30: 835-838.
12. Mindel A, Taylor J, Tideman RL, et al. Neonatal
herpes prevention: a minor public health problem
in some communities. Sex Transm Infect 2000; 76:
287-291.
13. Cowan FM, Johnson AM, Ashley R, et al. Antibody
to herpes simplex virus type 2 as serological marker
of sexual lifestyle in populations. BMJ 1994; 309:
1325-1329.
14. Whitley RJ, Nahmias AJ, Visintine AM, et al. The
natural history of herpes simplex virus infection of
mother and newborn. Pediatrics 1980; 66: 489-494.
15. Whitley RJ, Corey L, Arvin A, et al. Changing presentation
of herpes simplex virus infection in neonates.
J Infect Dis 1988; 158: 109-116.
16. Fleming DT, McQuillan GM, Johnson RE, et al.
Herpes simplex virus type 2 in the United States,
1976 to 1994. N Engl J Med 1997; 337: 1105-1111.
17. Parvey LS, Ch'ien LT. Neonatal herpes simplex virus
infection introduced by fetal-monitor scalp electrodes.
Pediatrics 1980; 65: 1150-1153.
18. Brown ZA, Wald A, Morrow RA, et al. Effect of
serologic status and cesarean delivery on transmission
rates of herpes simplex virus from mother
to infant. JAMA 2003; 289: 203-209.
19. Yeager AS, Arvin AM, Urbani LJ, Kemp JA. Relationship
of antibody to outcome in neonatal herpes
simplex virus infections. Infect Immun 1980; 29:
532-538.
20. Brown Z. Preventing herpes simplex virus transmission
to the neonate. Herpes 2004; 11 (Suppl 3): 175A-
186A.
21. Brown ZA, Gardella C, Wald A, et al. Genital herpes
complicating pregnancy. Obstet Gynecol 2005; 106:
845-856.
22. Light IJ. Postnatal acquisition of herpes simplex virus
by the newborn infant: a review of the literature.
Pediatrics 1979; 63: 480-482.
23. Linnemann CC, Buchman TG, Light IJ, Ballard JL.
Transmission of herpes-simplex virus type 1 in a
nursery for the newborn. Identification of viral isolates
by D.N.A. "fingerprinting". Lancet 1978; 1: 964-966.
24. Douglas J, Schmidt O, Corey L. Acquisition of neonatal
HSV-1 infection from a paternal source contact.
J Pediatr 1983; 103: 908-910.
25. Sullivan-Bolyai JZ, Fife KH, Jacobs RF, et al. Disseminated
neonatal herpes simplex virus type 1 from a maternal
breast lesion. Pediatrics 1983; 71: 455-457.
26. Yeager AS, Ashley RL, Corey L. Transmission of herpes
simplex virus from father to neonate. J Pediatr
1983; 103: 905-907.
27. Brown ZA, Vontver LA, Benedetti J, et al. Effects on
infants of a first episode of genital herpes during
pregnancy. N Engl J Med 1987; 317: 1246-1251.
28. Whitley RJ. Neonatal herpes simplex virus infections:
is there a role for immunoglobulin in disease prevention
and therapy? Pediatr Infect Dis J 1994; 13: 432-
438; discussion 438-439.
29. Pouletty P, Chomel JJ, Thouvenot D, et al. Detection
of herpes simplex virus in direct specimens by immunofluorescence
assay using a monoclonal antibody.
J Clin Microbiol 1987; 25: 958-959.
30. Cone RW, Hobson AC, Brown Z, et al. Frequent
detection of genital herpes simplex virus DNA by
N. DALGIÇ
31
Cerrahpaşa Tıp Derg 2007; 38: 24 - 31
polymerase chain reaction among pregnant women.
JAMA 1994; 272: 792-796.
31. Malm G, Forsgren M. Neonatal herpes simplex virus
infections: HSV DNA in cerebrospinal fluid and
serum. Arch Dis Child Fetal Neonatal Ed 1999; 81:
24-29.
32. Atkins JT. HSV PCR for CNS infections: pearls and
pitfalls. Pediatr Infect Dis J 1999; 18: 823-824.
33. ACOG practice bulletin. Management of herpes in
pregnancy. Clinical management guidelines for
obstetrician-gynecologists. Int J Gynaecol Obstet
2000; 68: 165-173.
34. Kimberlin DW, Lin CY, Jacobs RF, et al. Safety and
efficacy of high-dose intravenous acyclovir in the
management of neonatal herpes simplex virus infections.
Pediatrics 2001; 108: 230-238.
35. Bravo FJ, Bourne N, Harrison CJ, et al. Effect of antibody
alone and combined with acyclovir on neonatal
herpes simplex virus infection in guinea pigs. J Infect
Dis 1996; 173: 1-6.
36. Baron S, Worthington MG, Williams J, Gaines JW.
Postexposure serum prophylaxis of neonatal herpes
simplex virus infection of mice. Nature 1976; 261:
505-506.
37. Stray-Pedersen B. Acyclovir in late pregnancy to
prevent neonatal herpes simplex. Lancet 1990; 336:
756.
38. Haddad J, Langer B, Astruc D, et al. Oral acyclovir
and recurrent genital herpes during late pregnancy.
Obstet Gynecol 1993; 82: 102-104.

Thank you for copying data from http://www.arastirmax.com