You are here

Home » Content

Evre IV Mide Karsinomlu Hastalarda Palyatif Gastrektominin Değeri

Value of palliative gastrectomy in patients with stage IV gastric carcinoma

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Objectives: The role of palliative gastrectomy in stage IV gastric carcinoma is controversial. In this study, the effect of palliative gastrectomy on the survival in patients with stage IV gastric carcinoma was investigated. Methods: One hundred eighty three stage IV gastric carcinoma patients who were followed-up until death were included in the study; data was collected prospectively. Patients with gastrectomy were compared to those without gastrectomy in regard to mortality and overall survival time; the patients who dead due to operative causes (30 patients) were not included in survival analysis. Results: Mortality ratio was 9.6% in patients with gastrectomy and 19.1% in patients without gastrectomy (p=0.181). Median survival time for 47 patients with gastrectomy (6.5 months) was significantly longer than 106 patients without resection (3.5 months) (p=0002); gastrectomy procedure had an independent prognostic significance (p<0.001). When the survival analysis was performed according to the extent of disease, the survival time was significantly longer in patients with gastrectomy than those without gastrectomy both in patients with locoregional disease (8 months versus 5 months; p=0.0343) and in patients with distant metastasis (6 months versus 2.5 months; p< 0.0001). Conclusion: Palliative gastrectomy should be performed in stage IV gastric carcinoma patients with good nutritional and general status since it does not have an increased mortality and provides a survival benefit, even for a short period of time, in comparison with nonresectional surgical procedures.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-evre-iv-mide-karsinomlu-hastalarda-palyatif-gastrektominin-degeri.pdf
  • 2
49-55
  • Turkish

REFERENCES

References: 

1. Maekawa S, Saku M, Maehara Y, et al. Surgical treatment
for advanced gastric cancer. Hepatogastroenterology
1996; 43: 178-186.
2. Ouchi K, Sugawara T, Ono H, et al. Therapeutic significance
of palliative operations for gastric cancer for
survival and quality of life. J Surg Oncol 1998; 69: 41-
44.
3. Kim J-P, Lee J-H, Kim S-J, et al. Clinicopathologic
characteristics and prognostic factors in 10783
patients with gastric cancer. Gastric Cancer 1998; 1:
125-133.
4. Yagi Y, Seshimo A, Kameoka S. Prognostic factors in
stage IV gastric cancer: Univariate and multivariate
analyses. Gastric Cancer 2000; 3: 71-80.
5. Haugstvedt T, Viste A, Eiede GE, et al. The survival
benefit of resection in patients with advanced stomach
cancer: the Norwegian multicenter experience.
World J Surg 1989; 13: 617-622.
6. Hartgrink HH, Putter H, Kranenbarg EK, et al. Value
of palliative resection in gastric cancer. Br J Surg
2002; 89: 1438-1443.
7. Wayne JD, Bell RH. Limited gastric resection. Surg
Clin N Am 2005; 85: 1009-1020.
8. Saidi RF, ReMine SG, Dudrick PS, Hanna NN. Is there
a role for palliative gastrectomy in patients with stage
IV gastric cancer? World J Surg 2006; 30: 21-27.
9. Lim S, Muhs BE, Marcus SG, et al. Results following
resection for stage IV gastric cancer; are better outcomes
observed in selected patient subgroups? J Surg
Oncol 2007; 95: 118-122.
10. Greene FL, Page DL, Fleming ID, et al, eds. AJCC
Cancer Staging Manual. 6th ed. New York: Springer-
Verlag; 2002: 111-118.
11. Wittekind C, Compton CC, Greene FL, Sobin LH.
TNM residual tumor classification revisited. Cancer
2002; 94: 2511-2519.
12. Doglietto GB, Pacelli F, Caprino P, et al. Palliative
surgery for far-advanced gastric cancer: A retrospective
study on 305 consecutive patients. Am Surg
1999; 65: 352-355.
13. Moriwaki Y, Kunisaki C, Kabayashi S, et al. Does the
surgical stress associated with palliative resection for
patients with incurable gastric cancer with distant
metastasis shorten their survival? Hepatogastroenterology
2004; 51: 872-875.
14. Chow LW, Lim BH, Leung SY, et al. Gastric carcinoma
with synchronous liver metastases: Palliative gastrectomy
or not? Aust N Z Surg 1995; 65: 719-723.
15. Kunisaki C, Shimada H, Akiyama H, et al. Survival
benefit of palliative gastrectomy in advanced incurable
gastric cancer. Anticancer Res 2003; 23: 1853-
1858.
16. Yoshikawa T, Kanari M, Tsuburaya A, et al. Should
gastric cancer with peritoneal metastasis be treated
surgically? Hepatogastroenterology 2003; 50: 1712-
1715.
17. Medina-Franco H, Contreras-Saldivar A, Ramos-De
La Medina A, et al. Surgery for stage IV gastric cancer.
Am J Surg 2004; 187: 543-546.
18. Demir G, Özgüro¤lu M, Molinas-Mandel N, ve ark.
Mide kanserinde olgular›m›z: 252 vakan›n
de¤erlendirilmesi. Cerrahpafla T›p Dergisi 1997; 28:
37-42.
19. Dökmeci G, Ulusoy E, Özdemir S, ve ark. Mide
kanserli 69 olgunun analizi. Türk Gastroenteroloji
Dergisi 1996; 7: 335-339.
20. Bozzetti F, Bonfanti G, Audisio A, et al. Prognosis of
patients after palliative surgical procedures for carcinoma
of the stomach. Surg Gynecol Obstet 1987;
164: 151-154.
54
N. Duraker
55
21. Hanazaki K, Sodeyama H, Mochizuki Y, et al.
Palliative gastrectomy for advanced gastric cancer.
Hepatogastroenterology 2001; 48: 285-289.
22. Kikuchi S, Arai Y, Morise M, et al. Gastric cancer with
metastases to the distant peritoneum: A 20-year surgical
experience. Hepatogastroenterology 1998; 45:
1183-1188.
23. Fujisaki S, Tomita R, Nezu T, et al. Prognostic studies
on gastric cancer with concomitant liver metastases.
Hepatogastroenterology 2001; 48: 892-894.
24. Monson JRT, Donohue JH, McIlrath DC, et al. Total
gastrectomy for advanced cancer: A worthwhile palliative
procedure. Cancer 1991; 68: 1863-1868.

Thank you for copying data from http://www.arastirmax.com