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Erkek Wistar Ratlarında (Rattus rattus norvegicus) Kalitatif ve Kantitatif Protein Yetersizliklerinin Canlı Ağırlık ve Bazı Organ Ağırlıkları Üzerine Etkileri

Journal Name:

  • Cumhuriyet Üniversitesi Fen Fakültesi Fen Bilimleri Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this study, the effects of severe qualitative and quantitative protein malnutrion on body weight and weights of certain organs were studied on 60 two months old male Wistar rats (Rattus rattus norvegicus). For this purpose 4 experiments were carried out In these experiments 15 animals, devided in equale three groups were fed with a rat chow diet (control group), a semisynthetic diet containing gelatine as protein source (gelatin-fed group) and no protein (N-free group) for 1, 2, 3 or 4 weeks. At the end of experimental periods animals were euthanized and body and organ weights were recorded. During the experiment the mean body weights of animals in control groups showed an increase while the of malnourished groups exhibited a time-dependent decrease varying between 25% and 58% when compared to the relevant controls (p<0.01). Furthermore, there were also significant differences between two malnourished groups (p<0.01). Also, the organs interested were affected by malnutrition negatively, in general. Spleen, liver, pancreas, testes, kidneys and heart were the most effected organs. However, the effects of malnutrition on the weight of the brain and eyes were relatively sparse.
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Abstract (Original Language): 
Çalışmada iki aylık 60 adet erkek Wistar ratında (Rattus rattus norvegicus) ileri düzeydeki kalitatif ve kantitatif protein yetmezliklerinin vücut ve organ ağırlıkları üzerine zamana bağlı etkileri incelendi. Bu amaçla dört deney gerçekleştirildi. Her deneyde 15 hayvan eşit üç gruba ayrılarak normal yetiştirme yemi (kontrol grubu), protein taşıyıcısı olarak %20 jelatin içeren (jelatin verilen grup) ve protein içermeyen (N-free grup) yemlerle 1, 2, 3 veya 4 hafta süreyle beslendiler. Her deneyin sonunda hayvanlar ötenazi edilerek canlı ağırlıkları ve organ ağırlıkları belirlendi. Deney sürecinde kontrol grubunda canlı ağırlıkta artma gözlenirken malnütrisyon gruplarında deney sürecine bağlı olarak % 25 ile % 58 arasında azalmalar kaydedildi (p<0.01). Ayrıca, jelatin ve N-free gruplar arasında da anlamlı farklılıklar görüldü (p<0.01). Malnütrisyon genelde organ ağırlıklarını da olumsuz olarak etkiledi. Dalak, karaciğer, pankreas, testisler, böbrekler ve kalp malnütrisyondan en çok etkilenen organlardı. Buna karşın beyin ve göz görece çok daha az etkilendikleri gözlemlendi.
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  • 1
48-60
  • Turkish

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