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THE EFFECTS OF ADMINISTRATION OF VALPROIC ACID ON BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) AND DEPRESSION OF ANIMAL ALZHEIMER’S DISEASE DURING EIGHT WEEK LONG ENDURANCE EXERCISES

Journal Name:

  • Cumhuriyet Üniversitesi Fen Fakültesi Fen Bilimleri Dergisi

Publication Year:

  • 2015

Key Words:

Author NameUniversity of Author
Abstract (2. Language): 
The objective of the present study is to analyze the effects of administration of valproic acid on Brain Derived Neurotrophic Factor (BDNF) and depression of alzheimer’s disease of desert rat during eight week long endurance exercises. In order to administer the study, 140 Sprague Dawley desert rats (70 of which are male and the other half, female) are categorized randomly into seven research groups, which includes 1) control group 2) sham group and testing groups 3) long distance training group 4) valproic acid 100 group 5) valproic acid 200 group 6) training group of valproic acid 100 7) training group of valproic acid 200. During the eight week period, research desert rats of groups 3, 6 and 7 run for 15 minutes and 30 seconds on zero gradient laboratory treadmill, with the speed of 15 to 20 meters per minute in each training lapse. The lapses are frequented five times a week. Furthermore, for a 14 day period, groups 4 and 6 are daily administered with 100 milligrams valproic acid on kilogram and groups 5 and 7 are daily administered with 200 milligrams valproic acid. Research Methodology. For research data analysis, one-way variance test and post hoc Tukey’s test are utilized. The findings indicate that the level of BDNF in all the research groups is significantly higher than the sham group (p<0.05) and Tumor Necrosis Factor Alpha (TNF) and depression level of all the research groups are significantly lower than the sham group (p<0.05). Research Findings. According to the research findings, it is indicated that endurance exercises, valproic acid and their synthetic administration increase the level of BDNF and decrease the levels of TNF and depression in desert rats with alzheimer’s disease.
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