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Swiss Albino Farelerde Fenpiroksimat (Akarisit)’ın Teşvik Ettiği Biyokimyasal Değişime Karşı Fındığın Koruyucu Rolü

Protective Effect of Nuts Against Fenpyroximate (Acaricide)-Induced Biochemical Alteration in Swiss Albino Mice

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Abstract (2. Language): 
Fenpyroximate is a pyrazole acaricide with selective activity against important phytophagous mites in the families’ Tetranychidae, Eriophyiidae, and Tarsonemidae. The goal of this study was to evaluate the toxicity of Fenpyroximate acaricide on selected biochemical parameters in Swiss albino mice. And also, we investigated the protective role of nuts against Fenpyroximate induced biochemical alterations. Mice were randomly divided into four (4) groups consisting of one (1) control and three (3) experimental groups. At the end of the experimental period, blood samples for the biochemical analysis were obtained from all mice after being lightly anesthetized with ether and specimens of kidney and liver were removed and prepared for measurement. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine levels were analyzed from serum. Malondialdehyde (MDA) and reduced glutathione (GSH) levels were analyzed from isolated tissues. The results showed that the mice treatment with Fenpyroximate showed a significant increase (p<0.05) in levels of AST, ALT, BUN, creatinine and MDA, while GSH showed a significant decrease (p<0.05) to compared with control group. Mice that were given nuts in combination with Fenpyroximate showed a significant decrease (p<0.05) in AST, ALT, BUN, creatinine and MDA, while GSH was significantly increased (p<0.05) to compared with Fenpyroximate group. We can conclude that feed with nuts showed significant protection against biochemical damage induced by Fenpyroximate.
Abstract (Original Language): 
Fenpiroksimat Tetranychidae, Eriophyiidae ve Tarsonemidae ailelerindeki önemli fitofag akarlarına karşı mücadelede kullanılan pirazol bir akarisittir. Bu çalışmanın amacı, Swiss albino farelerde seçilen biyokimyasal parametreler üzerine Fenpiroksimat akarisitinin toksisitesini değerlendirmek ve bu biyokimyasal değişimlere karşı fındığın koruyucu rolünü araştırmaktır. Fareler rastgele bir (1) kontrol ve üç (3) uygulama olmak üzere toplam dört (4) gruba ayrılmıştır. Deneysel periyodun sonunda, tüm fareler hafif eter anestezisi altında bayıltılmış, biyokimyasal analiz ve ölçümler için kan örnekleri ile karaciğer ve böbrek dokuları elde edilmiştir. Serum Aspartat Aminotransferaz (AST), Alanin Aminotransferaz (ALT), Kan Üre Nitrojen (BUN) ve kreatinin seviyeleri ölçülmüş, elde edilen dokularda ise Malondialdehit (MDA) ve Glutatyon (GSH) seviyeleri analiz edilmiştir. Sonuçta, kontrol grubu ile karşılaştırıldığında Fenpiroksimat uygulanan farelerde GSH seviyelerinde önemli bir azalma (p<0.05), AST, ALT, BUN, kreatinin ve MDA seviyelerinde ise önemli bir artış (p<0.05) görülmüştür. Fenpiroksimat uygulama grubu ile karşılaştırıldığında, Fenpiroksimat ile birlikte fındık uygulaması GSH seviyelerinde tekrar önemli bir artışa (p<0.05), AST, ALT, BUN, kreatinin ve MDA seviyelerinde ise önemli bir azalmaya (p<0.05) neden olmuştur. Sonuç olarak, fındık ile beslemenin Fenpiroksimat tarafından teşvik edilen biyokimyasal hasara karşı önemli bir koruma sağladığı söylenebilir.

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